Search results for "MESH: Muscle"

showing 3 items of 13 documents

Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius.

2007

International audience; Aging triggers several abnormalities in muscle glycolytic fibers including increased proteolysis, reactive oxygen species (ROS) production and apoptosis. Since the mitochondria are the main site of substrate oxidation, ROS production and programmed cell death, we tried to know whether the cellular disorders encountered in sarcopenia are due to abnormal mitochondrial functioning. Gastrocnemius mitochondria were extracted from adult (6 months) and aged (21 months) male Wistar rats. Respiration parameters, opening of the permeability transition pore and ROS production, with either glutamate (amino acid metabolism) or pyruvate (glucose metabolism) as a respiration substr…

Malemuscle atrophyMESH : Cell Aging[SDV]Life Sciences [q-bio]MESH : Reactive Oxygen SpeciesMitochondrion0302 clinical medicineGlycolysisMESH: AnimalsMESH : Muscle SkeletalMESH : Fatty AcidsCellular SenescencePhospholipidsMESH: Superoxide Dismutasereactive oxygen speciesMESH : Free Radicals0303 health sciencesMESH: Muscle SkeletalMESH : RatsFatty Acidsfatty acid profile of mitochondrial lipidsMESH: Reactive Oxygen SpeciesPyruvate dehydrogenase complexMESH: Fatty Acidsmitochondria[SDV] Life Sciences [q-bio]BiochemistryMESH: Cell AgingMESH: CalciumMESH : MitochondriaCell agingPyruvate decarboxylationmedicine.medical_specialtyFree RadicalsMESH: RatsCellular respirationMESH: MitochondriaMESH : MaleCell Respirationchemistry.chemical_elementOxidative phosphorylationBiologyCalciumMESH : Rats WistarMESH : Phospholipids03 medical and health sciencesMESH: Free RadicalsInternal medicinemedicineAnimalsMESH : Superoxide DismutaseRats WistarMuscle SkeletalMESH : Calcium030304 developmental biologyMESH: Phospholipidscalciumpermeability transition poreSuperoxide Dismutaseagingaging;calcium;fatty acid profile of mitochondrial lipids;mitochondria;muscle atrophy;permeability transition pore;reactive oxygen species;Animals;Calcium;Cell Aging;Cell Respiration;Fatty Acids;Free Radicals;Male;Mitochondria;Muscle;Skeletal;Phospholipids;Rats;Wistar;Reactive Oxygen Species;Superoxide DismutaseCell BiologyMESH: Rats WistarMESH: MaleRatsEndocrinologychemistryMESH : Cell RespirationMESH : AnimalsMESH: Cell Respiration030217 neurology & neurosurgery
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Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

2007

International audience; The management of premature birth still remains unsatisfactory. Since the relative lack of efficiency and/or safety of current tocolytic agents have been highlighted, it is necessary to develop new uterorelaxant drugs deprived of important maternal and foetal side effects. Our work reported in this review focuses on a potential new target for tocolytic drugs, the beta3-adrenoceptor (ADRB3). This third type of ADRB is shown to be present and functional in human myometrium. We demonstrated that ADRB3 agonists are able to inhibit in-vitro spontaneous contractions of myometrial strips, via a cyclic AMP-mediated pathway. Furthermore, we established that ADRB3 is the predo…

Muscle RelaxationMESH : Receptors Adrenergic beta-3MESH : Adrenergic beta-AgonistsUterusAdrenergic beta-3 Receptor AgonistsMESH: Adrenergic beta-AgonistsPharmacologyUterine contractionUterine Contraction0302 clinical medicineMESH: PregnancyMESH : UterusPregnancyObstetrics and GynaecologyMedicineMESH : FemaleMESH: Obstetric Labor Premature[ SDV.MHEP.GEO ] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricsreproductive and urinary physiology0303 health sciencesMESH : MyometriumMyometriumMESH : Obstetric Labor PrematureObstetrics and GynecologyAdrenergic beta-Agonists3. Good healthmedicine.anatomical_structureMuscle relaxation030220 oncology & carcinogenesisTocolyticMESH: Uterine ContractionMyometriumMESH: MyometriumMESH: UterusFemalemedicine.symptomTocolytic agentmedicine.medical_specialtyAdrenergic receptorAdrenergic beta-3 Receptor Agonists[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricsMESH : Muscle Relaxation03 medical and health sciencesObstetric Labor PrematureInternal medicineHumans030304 developmental biologyMESH: Humansbusiness.industryMESH : HumansUterus[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricsMESH : PregnancyEndocrinologyProceedingsReceptors Adrenergic beta-3MESH: Muscle RelaxationbusinessMESH: Receptors Adrenergic beta-3MESH: FemaleMESH : Uterine Contraction
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Subliminal fear priming potentiates negative facial reactions to food pictures in women with anorexia nervosa.

2010

BackgroundTo investigate hedonic reactivity and the influence of unconscious emotional processes on the low sensitivity to positive reinforcement of food in anorexia nervosa (AN).MethodAN and healthy women were exposed to palatable food pictures just after a subliminal exposure to facial expressions (happy, disgust, fear and neutral faces), either while fasting or after a standardized meal (hungerversussatiety). Both implicit [facial electromyographic (EMG) activity from zygomatic and corrugator muscles, skin conductance, heart rate, and videotaped facial behavior] and explicit (self-reported pleasure and desire) measures of affective processes were recorded.ResultsIn contrast to healthy wo…

PleasureMESH : Galvanic Skin ResponseAnorexia NervosaMESH : Recognition (Psychology)AudiologyDevelopmental psychologyAdult Affect Analysis of Variance Anorexia Nervosa/ psychology Cues Electromyography/methods/statistics & numerical data Face Facial Expression Fear/ psychology Female Food Galvanic Skin Response Heart Rate Humans Hunger Motivation MuscleMESH : FearTask Performance and AnalysisEmotional expressionMESH : Task Performance and AnalysisMESH : Muscle Skeletalmedia_commonMESH : Reinforcement (Psychology)MESH: Subliminal Stimulationdigestive oral and skin physiologyFearMESH: Recognition (Psychology)MESH: Reinforcement (Psychology)Facial ExpressionPsychiatry and Mental healthMESH: Photic StimulationMESH: PleasureMESH : MotivationVisual PerceptionMESH : FaceMESH : FoodFacial electromyographyReinforcement PsychologyMESH: Anorexia NervosaMESH : Visual Perceptionmedicine.medical_specialtymedia_common.quotation_subjectMESH: MotivationMESH : Facial ExpressionMESH: ElectromyographyMESH : HungerHumansMESH: HumansMESH: SatiationMESH: Visual PerceptionMESH : CuesElectromyographyMESH : HumansRecognition PsychologyMESH: AdultMESH: Task Performance and Analysismedicine.diseaseDisgustFoodFaceMESH: FemalePhotic StimulationMESH: CuesMESH: Facial ExpressionHunger[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionMESH: FearMESH : Photic StimulationMESH : Analysis of VarianceAnorexia nervosaHeart RateMESH: Unconscious (Psychology)MESH : FemaleMESH: Heart RateApplied PsychologyMESH: Muscle SkeletalUnconscious PsychologyMESH: AffectGalvanic Skin ResponseMESH : AdultSkeletal Photic Stimulation/ methods Pleasure Recognition (Psychology) Reinforcement (Psychology) Satiation Subliminal Stimulation Task Performance and Analysis Unconscious (Psychology) Visual PerceptionMESH : Unconscious (Psychology)MESH: HungerMESH: Galvanic Skin ResponseMESH : Anorexia NervosaMESH : ElectromyographyFemaleCuesPsychologyMESH : Subliminal StimulationPriming (psychology)MESH: FaceMESH: FoodAdultMESH : PleasureSatiationSubliminal StimulationPleasureMESH: Analysis of VariancemedicineMuscle SkeletalFacial expressionAnalysis of VarianceMotivationMESH : Heart RateSubliminal stimuliMESH : AffectAffect[SDV.AEN]Life Sciences [q-bio]/Food and NutritionMESH : Satiation
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