Search results for "MHC"

showing 3 items of 233 documents

Bacteria-specific cytotoxic CD8+ T cells: a missing link in the pathogenesis of the HLA-B27-associated spondylarthropathies.

1994

The term seronegative spondylarthropathies is used for an entity of rheumatic syndromes of peripheral joints and the spine (ankylosing spondylitis, reactive arthritis, Reiter's syndrome, arthritis in psoriasis and in inflammatory bowel disease) which are strongly associated with the MHC class I molecule HLA-B27. However, the mechanisms whereby HLA-B27 confers disease susceptibility have so far remained unknown. There is strong evidence that gut inflammation and infection with gram-negative bacteria play a role in the induction of B27-associated disease. HLA-B27, like other MHC class I molecules, physiologically binds antigenic peptides in its binding groove and presents them to CD8+ T lymph…

musculoskeletal diseasesCytotoxicity ImmunologicAnkylosisEpitopeEpitopesAntigenEnterobacteriaceaeMHC class IMedicineCytotoxic T cellAnimalsHumansSpondylarthropathiesHLA-B27 AntigenHLA-B27Antigens Bacterialbiologybusiness.industryArthritisSynovial MembraneGeneral MedicineDisease Models AnimalImmunologybiology.proteinBacterial antigenbusinessCD8Protein BindingT-Lymphocytes CytotoxicAnnals of medicine
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HLA class II haplotypes differentiate between the adult autoimmune polyglandular syndrome types II and III.

2013

Background: Genetics of the adult autoimmune polyglandular syndrome (APS) is poorly understood. Aim: The aim of this study was to gain further insight into the genetics of the adult APS types. Site: The study was conducted at a university referral center. Methods: The human leukocyte antigen (HLA) class II alleles, haplotypes, and genotypes were determined in a large cohort of patients with APS, autoimmune thyroid disease (AITD), and type 1 diabetes and in healthy controls by the consistent application of high-resolution typing at a four-digit level. Results: Comparison of the allele and haplotype frequencies significantly discriminated patients with APS vs AITD and controls. The HLA class…

musculoskeletal diseasesHla class iiAdultMaleendocrine system diseasesAdolescentEndocrinology Diabetes and MetabolismClinical BiochemistryGenes MHC Class IIHuman leukocyte antigenBiochemistryDiagnosis DifferentialYoung AdultEndocrinologyGene FrequencyAutoimmune Polyglandular SyndromeGenotypeMedicineHumansGenetic Predisposition to DiseaseTypingAlleleskin and connective tissue diseasesChildPolyendocrinopathies AutoimmuneType 1 diabetesbusiness.industryBiochemistry (medical)Haplotypenutritional and metabolic diseasesMiddle Agedmedicine.diseaseHaplotypesCase-Control StudiesImmunologyFemalebusinessThe Journal of clinical endocrinology and metabolism
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H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove.

1996

The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibilityI-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequencedH2-Ma, H2-Mb1, andH2-Mb2 genes from CIA-susceptible and-resistant mouse strains and identified four differentMa andMb2 alleles and three differentMb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share commonMa, M…

musculoskeletal diseasesImmunologyGenes MHC Class IIMolecular Sequence DataGenes MHC Class IPeptide bindingMice Inbred StrainsMajor histocompatibility complexEpitopeMiceAntigenMHC class IGeneticsAnimalsAmino Acid SequencePhylogenyDNA PrimersMHC class IIPolymorphism GeneticbiologyBase SequenceSequence Homology Amino AcidAntigen processingH-2 AntigensHistocompatibility Antigens Class IIMolecular biologyArthritis ExperimentalHistocompatibilityHaplotypesbiology.proteinCollagenSequence AlignmentImmunogenetics
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