Search results for "MICE"

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.

2015

The immunostimulatory ability of synthetic oligonucleotides containing CpG motifs (CpG-ODN), agonists of Toll-like receptor 9 (TLR9), can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, particularly in the lung, tumor-associated immunosuppression can subvert such antitumor innate immune responses. To locally maintain continuous activation of innate subpopulations while inhibiting immunosuppressive cells, we evaluated aerosol delivery CpG-ODN combined with Poly(I:C), a TLR3 agonist able to convert tumor-supporting macrophages to tumoricidal effectors, in the treatment of B16 melanoma lung metastases …

Psychobiological effects of perinatal exposure to odorants in mice. Part I: Morphological changes in the olfactory epithelium

2010

International audience

Postnatal predator exposure reduces fear and anxiety behaviors in adult mice

2010

Poster; Predator cues are very efficient to induce fear in rodents but most studies use adult subjects and not pups. Nevertheless, a perinatal stress can have a significant effect on behavior and on physiology at adulthood. An early stress (foot shock, restraint, mother separation) is able to modulate behaviors later and the aim of this study was to examine if the synthetic predator odor 2,3,5-trimethylthiazoline (TMT) presented to neonates modifies fear and anxiety-related behaviors in adult female mice.

Prevention of TNBS-induced colitis by probiotic supplement in mice

2014

Role of intracellular calcium on ethanol-induced activation of protein kinase A: molecular model and behavioral consequences

2014

Ethanol can be considered a weak drug when compared to most other drugs of abuse. The molecule of ethanol has no asymmetric carbon. Being so, it does not interact with the biological substrates in a stereoselective way as most of the receptor ligand drugs do. Moreover, ethanol has a very simple chemical structure. Thus, the hydroxyl group provides a dipole that allows the formation of hydrogen bonds. It is the formation of hydrogen bonds that makes ethanol soluble in water. In contrast, ethanol presents an aliphatic moiety that provides a lipophilic group that can interact with non-polar cellular elements. However, contrary to what it is generally believed, ethanol has low lipid solubility.…

POLYMERIC MICELLES AS DRUG DELIVERY SYSTEMS TOWARDS BRAIN TARGETING

2009

About molds

2016

I funghi provocano talora disturbi dell’apparato respiratorio e sebbene alcuni semplici provvedimenti possano rivelarsi determinanti per prevenirne lo sviluppo in ambiente domestico, la loro ubiquità fa sì che essi si sviluppino sia outdoor che indoor. Un fattore predisponente allo sviluppo di asma bronchiale è la sensibilizzazione allergica, mentre l’inquinamento ambientale gioca un altro ruolo di rilievo anche nelle altre patologie legate all’esposizione a muffe: l’aspergillosi broncopolmonare allergica, la rinosinusite, la sick building syndrome e la sindrome da polveri organiche tossiche. L’immunoterapia specifica, in virtù del suo ormai accertato potere desensibilizzante, rappresenta u…

Differentiation among dairy products by combination of fast field cycling NMR relaxometry data and chemometrics

2021

A set of commercial milk and Sicilian cheeses was analysed by a combination of fast field cycling (FFC) nuclear magnetic resonance (NMR) relaxometry and chemometrics. The NMR dispersion (NMRD) curves were successfully analysed with a mathematical model applied on Parmigiano-Reggiano (PR) cheese. Regression parameters were led back to the molecular components of cheeses (water trapped in casein micelles, proteins and fats) and milk samples (water belonging to hydration shells around dispersed colloidal particles of different sizes and bulk water). The application of chemometric analysis on relaxometric data enabled differentiating milk from cheeses and revealing differences within the two sa…

Micelles in Mixtures of Sodium Dodecyl Sulfate and a Bolaform Surfactant

2006

Mixtures composed of water, sodium dodecyl sulfate (SDS), and a bolaform surfactant with two aza-crown ethers as polar headgroups (termed Bola C-16) were investigated by modulating the mole ratios between the components. The two surfactants have ionic and nonionic, but ionizable, headgroups, respectively. The ionization is due to the complexation of alkali ions by the aza-crown ether unit(s). Structural, thermodynamic, and transport properties of the above mixtures were investigated. Results from surface tension, translational self-diffusion, and small angle neutron scattering ( SANS) are reported and discussed. Interactions between the two surfactants to form mixed micelles result in a com…

Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

2015

Duchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However…