Search results for "MICELLES"

showing 3 items of 233 documents

A fluorescence study of the loading and time stability of doxorubicin in sodium cholate/PEO-PPO-PEO triblock copolymer mixed micelles

2019

Abstract Hypothesis Doxorubicin hydrochloride (DX) is one of the most powerful anticancer agents though its clinical use is impaired by severe undesired side effects. DX encapsulation in nanocarrier systems has been introduced as a mean to reduce its toxicity. Micelles of the nonionic triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) (PEO-PPO-PEO), are very promising carrier systems. The positive charge of DX confines the drug to the hydrophilic corona region of the micelles. The use of mixed micelles of PEO-PPO-PEO copolymers and a negatively charged bile salt should favour the solubilization of DX in the apolar core region of the micelles. Experiments We st…

small angle X-raymacromolecular substances02 engineering and technology010402 general chemistry01 natural sciencesMicelledoxorubicinFluorescence spectroscopyfluorescence; doxorubicin; pluronics bile salts; dynamic light scattering; small angle X-ray; scattering drug-deliveryPolyethylene GlycolsBiomaterialsColloid and Surface ChemistryDynamic light scatteringX-Ray DiffractionScattering Small AngleCopolymerMicellesDrug CarriersAqueous solutionAntibiotics AntineoplasticSmall-angle X-ray scatteringChemistrytechnology industry and agricultureWaterdynamic light scatteringPoloxamer021001 nanoscience & nanotechnologySodium Cholate0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialspluronics bile saltsSpectrometry FluorescenceChemical engineeringSolubilityPropylene Glycolsscattering drug-deliveryfluorescenceNanocarriers0210 nano-technology
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Polymeric micelles containing squalenoyl chains for the delivery of drugs to the central nervous system

2011

squalenoyl micelles central nervous systemSettore CHIM/09 - Farmaceutico Tecnologico Applicativomicelles Drug delivery system squalenic
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Review: Mass spectrometry of surfactant aggregates

2011

In contrast with the enormous amount of literature produced during many decades in the field of surfactant aggregation in liquid, liquid crystalline and solid phases, only a few investigations concerning surfactant self-assembling in the gas phase as charged aggregates have been carried out until now. This lack of interest is disappointing in view of the remarkable theoretical and practical importance of the inherent knowledge. The absence of surfactant–solvent interactions makes it easier to study the role of surfactant–surfactant forces in determining their peculiar self-assembling features as well as the ability of these assemblies to incorporate selected solubilizate molecules. Thus, th…

surfactants charged aggregates gas phase reverse micelles mass spectrometry ESI-MS
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