Search results for "MICROPARTICLES"

The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma

2014

Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells d…

Spherical microparticles production by supercritical antisolvent precipitation: Interpretation of results

2008

Abstract Supercritical antisolvent micronization has been the subject of many works aimed at the production of precipitates with controlled particle size and morphology. Several morphologies have been observed; but, the production of spherical micrometric particles has been the major objective of most of the studies performed. Therefore, in this work, literature data analysis on spherical and related morphologies has been performed. The ranges of process conditions at which spherical microparticles have been obtained have been listed and discussed. A possible formation mechanism is proposed that is based on the competition between jet break-up and liquid surface tension vanishing characteri…

"One-touch" voltammetry of microparticles for the identification of corrosion products in archaeological lead

2011

Voltammetry of microparticles is applied to the identification of lead corrosion products by means of an essentially non-invasive 'one-touch' technique based on the use of graphite pencil. This methodology permits the mechanical attachment of few nanograms of sample from the surface of lead archaeological artefacts to a paraffin-impregnated graphite electrode, which, upon immersion in aqueous electrolytes, provides distinctive voltammetric responses for litharge and cotunnite- anglesite-, cerusite-based corrosion products. The reported method is applied to the identification of corrosion products in archaeological lead pieces from different Iberian sites in Valencia (Spain). © 2011 WILEY-VC…

Access to Phylogeny from Voltammetric Fingerprints of Seeds: the Apsparagus Case

2016

A methodology for characterizing vegetal taxonomic groups from the voltammetric fingerprints of polyphenolic components of seeds is described. It is based on recording the voltammetric response of microparticulate films deposited on glassy carbon electrodes from seed extracts using different organic solvents. The obtained responses in contact with aqueous electrolytes provided characteristic voltammetric profiles at the level of genera/subgenera and/or families using bivariant and multivariant chemometric methods. The voltammograms of 14 species from 5 different families provided family-characteristic patterns. Analysis of voltammetric responses for a set of 20 species of the Asparagus genu…

Thrombin generation - a potentially useful biomarker of thrombotic risk in Philadelphia-negative myeloproliferative neoplasms.

2017

The diagnosis of essential thrombocythemia and polycythemia vera is often made during a thrombotic event which can be serious. Philadelphia-negative chronic myeloproliferative neoplasia patients have an increased thrombotic risk. This is assessed using various scoring systems but these are far from ideal and individual risk. The currend trend to personalised medicine requires finding the most useful thrombotic risk biomarker in these patients. Routine tests for coagulation do not take account of both pro- and anti-coagulant factors which is why these tests are not useful in patients with Philadelphia-negative myeloproliferative neoplasms. Thrombin generation reflects more accurately the bal…

From Maya Blue to “Maya Yellow”: A Connection between Ancient Nanostructured Materials from the Voltammetry of Microparticles

2011

The yellow hue of a series of samples from wall paintings in several Mayan archaeological sites can be attributed to the presence of indigoid compounds, including isatin and dehydroindigo, attached to palygorskite, a local phyllosilicate clay. SEM/EDX, TEM, UV/Vis spectroscopy, and voltammetry of microparticles show that the ancient Mayas could prepare indigo, Maya Blue, and "Maya Yellow" during successive stages. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Microfluidic Synthesis of Actuating Microparticles from a Thiol-Ene Based Main-Chain Liquid Crystalline Elastomer.

2016

In this article the microfluidic synthesis of strongly actuating particles on the basis of a liquid crystalline main-chain elastomer is presented. The synthesis is carried out in a capillary-based co-flow microreactor by photo-initiated thiol-ene click chemistry of a liquid crystalline monomer mixture. These microparticles exhibit a deformation from a spherical to a rod-like shape during the thermal-initiated phase transition of the liquid crystalline elastomer (LCE) at which the particles’ aspect ratio is almost doubled. Repeated contraction cycles confirm the complete reversibility of the particles’ actuation properties. The transition temperature of the LCE, the temperature range of the …

Polyaspartamide based microparticles for Tobramycin delivery to the lung in FC therapy

2015

Inhalable polymeric microparticles as pharmaceutical porous powder for drug administration

2022

In this work, the production of inhalable polymeric microparticles with modulable porosity is described. The starting polymeric material was the PHEA-g-RhB-g-PLA graft copolymer, which was suitably processed by spray drying (SD). Thanks to the addition of AB (weight percentage equal to 10 and 20 % with respect to the polymer) in the liquid feed, three biocompatible matrices were obtained with an increasing porosity in terms of pore volume (from 0.015 to 0.024 cc/g) and pore average diameter (from 1.942 to 3.060 nm), a decreasing tapped density values (from 0.75 to 0.50), and favorable aerosolization characteristics. These differences were high-lighted also by a significant increase in the r…

Release and permeation profiles of spray-dried chitosan microparticles containing caffeic acid

2018

Made available in DSpace on 2018-12-11T17:17:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01 Caffeic acid (CA), a phenolic compound found in plants with antioxidant and antimicrobial activity, induces collagen production and prevents premature aging of the skin. The objective of this study was to develop two types of chitosan microparticles (MP) containing CA and to relate the morphology with the release and permeation profiles. One type of MP was prepared from a hydroalcoholic solution (MPI) and the other from an aqueous solution (MPII). Their morphology and size was evaluated by high-resolution scanning electron microscopy. The release profile of CA was evaluated using the…