Search results for "MIM"

Cartilage Repair and Regeneration: Focus on Multi-Disciplinary Strategies—Highlight on Magneto-Responsive Techniques

2021

This editorial focuses on the interesting studies published within the present Special Issue and dealing with the innovative multi-disciplinary therapeutic approaches for musculoskeletal diseases. Moreover, it highlights the noteworthy magneto-responsive technique for a cartilage regeneration scope and reports some interesting studies and their outcomes in this specific field.

Prove tecniche di recitazione in Terenzio. Il volto della messinscena.

2010

A Regio- and Diastereoselective Anodic Aryl-Aryl Coupling in the Biomimetic Total Synthesis of (-)-Thebaine.

2018

The biosynthesis of thebaine is based on the regioselective, intramolecular, oxidative coupling of (R)-reticuline. For decades, chemists have sought to mimic this coupling by using stoichiometric oxidants. However, all approaches to date have suffered from low yields or the formation of undesired regioisomers. Electrochemistry would represent a sustainable alternative in this respect but all attempts to accomplish an electrochemical synthesis of thebaine have failed so far. Herein, a regio- and diastereoselective anodic coupling of 3',4',5'-trioxygenated laudanosine derivatives is presented, which finally enables electrochemical access to (-)-thebaine.

Biomimetic synthesis of the tumor-associated (2,3)-sialyl-T antigen and its incorporation into glycopeptide antigens from the mucins MUC1 and MUC4.

2004

Glycoproteins on epithelial tumor cells often exhibit aberrant glycosylation profiles. The incomplete formation of the glycan side chains resulting from a down-regulated glucosamine transfer and a premature sialylation results in additional peptide epitopes, which become accessible to the immune system in mucin-type glycoproteins. These cancer-specific structure alterations are considered to be a promising basis for selective immunological attack on tumor cells. Among the tumor-associated saccharide antigens, the (2,3)-sialyl-T antigen has been identified as the most abundant glycan, found in several different carcinoma cell lines. According to a linear biomimetic strategy, the (2,3)-sialyl…

Promotion of osteogenic cell response using quasicovalent immobilized fibronectin on titanium surfaces: introduction of a novel biomimetic layer syst…

2012

Purpose Despite the undeniable potential of cell adhesion molecules such as fibronectin to support osteogenic cell responses and consecutive dental implant healing, the most beneficial mode of application onto titanium implant surfaces still requires investigation. Unspecific fibronectin adsorption on titanium dioxide (TiO2) surfaces can result in low-loading, high-desorption rates and protein–metal interactions with impaired biologic activity. The aim of the present study was to monitor the osteogenic cell responses (cell adhesion, proliferation, and differentiation) specifically to fibronectin biofunctionalized TiO2. Materials and Methods An innovative biomimetic streptavidin-biotin layer…

Biologically inspired information processing and synchronization in ensembles of non-identical threshold-potential nanostructures.

2013

Nanotechnology produces basic structures that show a significant variability in their individual physical properties. This experimental fact may constitute a serious limitation for most applications requiring nominally identical building blocks. On the other hand, biological diversity is found in most natural systems. We show that reliable information processing can be achieved with heterogeneous groups of non-identical nanostructures by using some conceptual schemes characteristic of biological networks (diversity, frequency-based signal processing, rate and rank order coding, and synchronization). To this end, we simulate the integrated response of an ensemble of single-electron transisto…

Biomimetic composites with enhanced toughening using silk-inspired triblock proteins and aligned nanocellulose reinforcements

2019

Silk-like proteins produced in bacteria are used as adhesives for cellulose nanofibrils to make a new biological material.

Come nani sulle spalle dei giganti. Il progetto di architettura tra mimesis e invento

2018

Abstract: The essay deals with the theme of mimesis and invention in architecture through the paradigm of transformation, understood as the practice of incessant references and re-elaborations. It does so starting from the theme of the transmission of knowledge in the Aristotelian key that there is always something that lies in what it becomes. The thesis is supported through references to painting, literature, linguistics and neuroscience and uses examples of the architecture of five critically analyzed and de-engineered masters.

Non-regular network performance comparison between HSDPA and LTE

2010

In this paper we study and benchmark the performance of 3rd Generation Partnership Project (3GPP) High Speed Downlink Packet Access (HSDPA) and 3GPP Long Term Evolution (LTE) Downlink with constant bit rate type traffic. In addition a non-regular simulation scenario is considered using realistic propagation data and base station positions related to Tokyo city downtown area. HSDPA was introduced in 3GPP Release 5 and in further releases the technology has been improved with e.g. receive and transmit diversity technologies and support for higher order modulation schemes. LTE was introduced in 3GPP Release 8 with completely new physical layer and improved Radio Resource Management (RRM) funct…

Comments on Guimarães & Sawaya. Pretending to be venomous: is a snake's head shape a trustworthy signal to a predator?

2011

Several species of non-venomous snake are known to flatten their heads when disturbed, and this behaviour has been suggested to be a mimicry of vipers (Arnold & Ovenden 2002, Hailey & Davies 1986, Young et al. 1999). Using plasticine models, Guimaraes & Sawaya (2011) tested the antipredatory function of a triangular head shape in snakes. Their article presents the first published empirical experiment testing the adaptive significance of vipers’ triangular head shape. Guimaraes & Sawaya (2011) found no support for the viper mimicry hypothesis. Accordingly, they concluded that ‘the shape of [the] head seemed not to confer advantage itself’. Although the use of plasticine models is a generally…