Search results for "MIM"

Lack of evidence of mimivirus replication in human PBMCs

2018

The Acanthamoeba polyphaga mimivirus (APMV) was first isolated during a pneumonia outbreak in Bradford, England, and since its discovery many research groups devoted efforts to understand whether this virus could be associated to human diseases, in particular clinical signs and symptoms of pneumonia. In 2013, we observed cytopathic effect in amoebas (rounding and lysis) inoculated with APMV inoculated PBMCs (peripheral blood mononuclear cell) extracts, and at that point we interpreted those results as mimivirus replication in human PBMCs. Based on these results we decided to further investigate APMV replication in human PBMCs, by transmission electron microscopy (TEM) and qPCR. No viral fac…

Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior

2019

Biological structures control cell behavior via physical, chemical, electrical, and mechanical cues. Approaches that allow us to build devices that mimic these cues in a combinatorial way are lacking due to there being no suitable instructive materials and limited manufacturing procedures. This challenge is addressed by developing a new conductive composite material, allowing for the fabrication of 3D biomimetic structures in a single manufacturing method based on two?photon polymerization. The approach induces a combinatorial biostimulative input that can be tailored to a specific application. Development of the 3D architecture is performed with a chemically actuating photocurable acrylate…

Partition of Indicaxanthin in Membrane Biomimetic Systems. A Kinetic and Modeling Approach

2009

The solubilization site of indicaxanthin (Ind) in lipid bilayers was investigated by the kinetics of Ind oxidation by peroxyl radicals in water and in aqueous/L-alpha-dipalmitoyl-phosphatidylcholine (DPPC) vesicles, pH 7.4, and 37.0 and 48.0 degrees C, that is, in a gel-like and a crystal liquidlike bilayer state, respectively. The time-dependent Ind absorbance decay, matched with a successful simulation of the reaction kinetic mechanism by Gepasi software, supported a multistep pathway. Computer-assisted analysis allowed calculation of the rate constants associated with the reactions involved, the values of which decreased with increasing DPPC concentration. The binding constant calculated…

Is COVID-19 a proteiform disease inducing also molecular mimicry phenomena?

2020

Is molecular mimicry the culprit in the autoimmune haemolytic anaemia affecting patients with COVID‐19?

2020

COVID-19 and molecular mimicry: The Columbus’ egg?

2020

Highlights • Recently, this Journal published a report about Guillain-Barré syndrome associated with COVID-19 infection. • Guillain-Barré syndrome can be due to molecular mimicry phenomena. • Molecular mimicry had already been described in another SARS. • It could explain the autoimmune signs and symptoms that some patients affected by SARS-CoV-2 can experience.

A Geometrical Channel Model for MIMO Mobile-to-Mobile Fading Channels in Cooperative Networks

2009

This paper deals with the modeling and analysis of narrowband multiple-input multiple-output (MIMO) mobile- to-mobile (M2M) fading channels in relay-based cooperative networks. Non-line-of-sight (NLOS) propagation conditions are assumed in the transmission links from the source mobile station to the destination mobile station via the mobile relay. A stochastic narrowband MIMO M2M reference channel model is derived from the geometrical three-ring scattering model, where it is assumed that an infinite number of local scatterers surround the source mobile station, the mobile relay, and the destination mobile station. The complex channel gains associated with the new reference channel model are…

A Geometrical Three-Ring-Based Model for MIMO Mobile-to-Mobile Fading Channels in Cooperative Networks

2011

Published version of an article published in the journal: Eurasip Journal on Advances in Signal Processing. Also available from the publisher at: http://dx.doi.org/10.1155/2011/892871. OA This paper deals with the modeling and analysis of narrowband multiple-input multiple-output (MIMO) mobile-to-mobile (M2M) fading channels in relay-based cooperative networks. In the transmission links from the source mobile station to the destination mobile station via the mobile relay, non-line-of-sight (NLOS) propagation conditions are taken into account. A stochastic narrowband MIMO M2M reference channel model is derived from the geometrical three-ring scattering model, where it is assumed that an infi…

A simulation model for wideband MIMO vehicle-to-vehicle fading channels in T-junction propagation environments

2010

In this paper, we propose a high-performance simulation model for wideband multiple-input multiple-output (MIMO) vehicle-to-vehicle (V2V) fading channels in T-junction propagation environments. The so-called Riemann sum method (RSM) is applied for the parametrisation of the simulation model. Furthermore, the statistical properties of the wideband MIMO V2V channel simulation model, such as the space-time-frequency cross-correlation function (STF-CCF), the two-dimensional spatial cross-correlation function (2D spatial CCF) and the temporal auto-correlation function (ACF) are studied. Finally, the high accuracy of the proposed simulation model is demonstrated by comparing the correlation prope…

Non-convex power allocation games in MIMO cognitive radio networks

2013

Consideramos un escenario de reparto del espectro, basado en la detección, en una red de radio cognitiva MIMO donde el objetivo general es maximizar el rendimiento total de cada usuario de radio cognitiva optimizando conjuntamente la operación de detección y la asignación de potencia en todos los canales, bajo una restricción de interferencia para los usuarios primarios. Los problemas de optimización resultantes conducen a un juego no convexo, que presenta un nuevo desafío a la hora de analizar los equilibrios de este juego. Con el fin de hacer frente a la no convexidad del juego, utilizamos un nuevo concepto relajado de equilibrio, el equilibrio cuasi-Nash (QNE). Se demuestran las condicio…