Search results for "MITO"
showing 10 items of 2513 documents
Cancer as a “Mitochondriopathy”.
2007
Mitochondria are subcellular organelles, whose well-known function is to produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). Alterations in respiratory activity and mtDNA appear to be a general feature of malignant cells. The presence of mtDNA mutations has been reported in various cancer cells, and the abundance of mtDNA damage is consistent with the intrinsic susceptibility to constitutive oxidative stress. Research about the functional aspects of mtDNA mutations in cancer development and therapeutic response is likely to be fruitful and to have significant clinical and prognostic impact. Although many studies to date have been focused on the identification an…
GENETIC NEUROCHAPERONOPATHIES ASSOCIATED WITH CCT5 AND HSP60 VARIANTS: ANALYSIS OF THEIR MOLECULAR ANATOMY AND POSSIBLE PATHOGENIC IMPLICATIONS
2022
Magnetic Resonance Spectroscopy: principles and clinical applications
2009
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differe…
2021
Tumors of the submandibular salivary gland (SMG) are uncommon but sufficiently frequent for the physician to consider them in routine examinations and for the pathologist to be prepared to differentiate them from other tissue abnormalities. However, scarcity of specimens makes training difficult, a situation compounded by the lack of accepted universal diagnostic guidelines. Furthermore, there is little information on the chaperone system (CS) of the gland, despite the increasing evidence of its participation in carcinogenesis as a biomarker for diagnosis and patient follow up, and in the mechanisms by which the tumor cells thrive. We are investigating this aspect of various tumors, and her…
Chaperonin Hsp60 and Cancer Therapies
2020
The heat shock protein 60 (Hsp60) is a chaperonin belonging to the chaperoning (chaperone) system that typically contributes to protein homeostasis inside mitochondria, but also plays various non-canonical roles unrelated to protein quality control beyond the organelle. Chaperonopathies are disorders in which chaperones play an etiologic-pathogenic role and contribute to the onset/progression of disease. Hsp60 chaperonopathies by mistake are diseases in which the chaperonin is apparently normal (as far as it can be determined with current methodologies) but it actively contributes to pathology, for example in certain types of cancer, and autoimmune and chronic inflammatory disorders. In cer…
Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death
2014
RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent.
2009
The Spindle Assembly Checkpoint (SAC) is a cellular surveillance mechanism that functions to ensure faithful chromosome segregation during mitosis. Failure of this checkpoint or alteration in expression of SAC proteins (MAD2, BUB1, BUBR1 and others) can result in aneuploidy, a state of having abnormal numbers of chromosomes. MAD2 haploinsufficiency resulted in aneuploidy in MEFs and colon cancer cells in culture. Thus, spindle checkpoint components might have additional functions not-checkpoint-related functions that when disrupted contribute to tumorigenesis. Here we investigated the effects of MAD2 or BUBR1 transcriptional silencing in HCT-116 cells. Transient reduction of MAD2 (40%) and …
L'origine e la meta : conversazione con Giuseppe Arcidiacono
2019
Sedici domande sulle ragioni del fare architettura (...al sud)
Elogio dell'eclettico e del provinciale
2019
"Eclettico" e "provinciale", due termini che trovano, nella ricerca architettonica di Giuseppe Arcidiacono, una significativa attualità.
Mediterraneo: mito, paisajes y arquitecturas silenciosas
2019
Il Mediterraneo è certamente l’ambito geografico compiuto e definito che, più di ogni altro, ha visto nascere, sviluppare ed evolvere le civiltà in grado di segnare la storia dell’Uomo. Punto di confronto tra oriente ed occidente, l’identità e la riconoscibilità del mito mediterraneo sta proprio nella molteplicità e nelle diversità delle culture e dei popoli che nel “bacino” si affacciano. L’articolo individua alcuni degli aspetti attraverso i quali è possibile leggere l’influenza del mito mediterraneo nell’architettura contemporanea. Aspetti da intendersi quale monumentum nel senso del valore del monere, del ricordare l’inesauribile concettualizzazione del mythos la cui attualità sta propr…