Search results for "MK"

Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach.

2017

<b><i>Background:</i></b> Depression is one of the most frequent and costly mental disorders. While there is increasing evidence for the efficacy of online self-help to improve depression or prevent relapse, there is little evidence in blended care settings, especially combined with inpatient face-to-face psychotherapy. Therefore, we evaluated whether an evidence-based online self-help program improves the efficacy of inpatient psychotherapy. <b><i>Methods:</i></b> A total of 229 depressed patients were randomly allocated either to an online self-help program (intervention group [IG]; Deprexis) or an active control group (CG; weekly online inf…

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

2014

The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in larg…

Über die frühen Werke von Carl Gotthard Graß in der Akademischen Bibliothek der Universität Lettlands, über die Freundschaft, Antiquarismus in der Ge…

2020

Interneta veikala dzinis

2017

Kvalifikācijas darbā “Interneta veikala dzinis” aprakstīta interneta veikalu dzinēja izstrāde. Sistēmas mērķis ir izveidot atvērta pirmkoda dzinēju, kas dot iespēju paātrināt interneta veikalu izstrādi nodrošinot visbiezāk pieprasītas sistēmas prasības. Sistēma ir izstrādāta Ruby programmēšanas valodā, ar Ruby on Rails ietvara palīdzību. Sistēmas izstrāde notika pēc spējās (Agile) programmatūras izstrādes pieejas.

Uzņēmuma informācijas sistēmas izveide izmantojot atvērtā pirmkoda programmatūru.

2015

Kvalifikācijas darba “Uzņēmuma informācijas sistēmas izveide izmantojot atvērtā pirmkoda programmatūru” mērķis bija izveidot uzņēmuma SIA “Aerobs” informācijas sistēmu, kurā uzņēmuma darbinieki varētu droši glabāt datus, koplietot tos, bet galvenais - sistēmas izveidē jāizmanto atvērtā pirmkoda programmatūra. Darba gaitā informācijas sistēma tika izveidota izmantojot virtualizāciju, tajā tika iekļauti sekojoši atvērtā pirmkoda risinājumi – Endian, Samba, BackupPC, Zabbix. Mērķis bija izveidot informācijas sistēmu, ko gala lietotāji var lietot izmantojot operētājsistēmas, kuru lietošanai nepieciešams iegādāties licenci, piemēram Windows 7. Rezultātā tika izveidota informācijas sistēma atbils…

The role of Aurora-A inhibitors in cancer therapy

2007

Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…

Latvijas bēgļu atgriešanās

1922

Whole-body biodistribution of the cannabinoid type 1 receptor ligand [ 18 F]MK-9470 in the rat

2017

The endocannabinoid system participates in many processes in the body, including memory, reward, pain, motor activity, food intake, energy metabolism, and gastrointestinal functions. [18F]MK-9470 is a positron emission tomography (PET) ligand that binds with high affinity and selectivity to the cannabinoid type 1 receptor. In order to fully characterize ligand behavior, tracer uptake measured using in vivo microPET was compared with results from ex vivo tissue dissection. Twelve male Sprague-Dawley rats were divided into three subgroups and scanned over time periods of 10min, 30min and 90min using PET. Afterwards, a number of the animals' organs were dissected. Uptake of radioactivity was e…

Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-γ1-driven activation of mTOR/p70S6-kinase pathway

2009

In chronic myeloid leukemia, activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway is crucial for survival and proliferation of leukemic cells. Essential downstream molecules involve mammalian target of rapamycin (mTOR) and S6-kinase. Here, we present a comprehensive analysis of the molecular events involved in activation of these key signaling pathways. We provide evidence for a previously unrecognized phospholipase C-gamma1 (PLC-gamma1)-controlled mechanism of mTOR/p70S6-kinase activation, which operates in parallel to the classical Akt-dependent machinery. Short-term imatinib treatment of Bcr-Abl-positive cells caused dephosphorylation of p70S6-K and S6-protein without inactivat…

Obcy czy inni? Czesi w Zelowie

2018

We wstępnej części artykułu zostaną zaprezentowane kategorie OBCY, INNY oraz SWÓJ w różnych konfiguracjach (opozycja komplementarna, triada), obecnych w dyskursie tożsamościowym. Następnie przedstawione zostaną determinanty tożsamości: konfesja i język grupy mieszkańców Zelowa – potomków czeskich emigrantów religijnych. W końcowej części artykułu podkreśla się, że obraz potomków czeskich emigrantów jest zmienny w czasie: początkowo była to grupa homogeniczna pod względem wyznaniowym, etnicznym i językowym, a obecnie jest grupą zasymilowaną językowo i kulturowo.