Search results for "ML"
showing 10 items of 1465 documents
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
2011
International audience; So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes; risk factors associated with RCC include smoking, obesity and hypertension. A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia-associated transcription factor (MITF) has been proposed to act as a melanoma oncogene; it also stimulates the transcription of hypoxia inducible factor (HIF1A), the pathway of which is targeted by kidney canc…
Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease
2011
14 páginas, 8 figuras, 1 tabla.-- et al.
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
2007
Abstract Background The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. Results Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of …
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.
2008
Contains fulltext : 70589.pdf (Publisher’s version ) (Closed access) OBJECTIVE: CO-releasing molecules (CO-RMs) are a novel class of anti-inflammatory agents. We have examined the possible therapeutic effects of CORM-3 in collagen-induced arthritis (CIA). METHODS: Arthritis was induced in DBA-1/J mice by type II collagen. Animals were treated with CORM-3 (5 and 10 mg/kg/day, intraperitoneally) or the inactive compound iCORM-3 (10 mg/kg/day, intraperitoneally) unable to release CO, from days 22 to 31. Production of anti-type II collagen antibodies, cytokines and cartilage olimeric matrix protein (COMP) was evaluated by enzyme-linked immunosorbent assay, and prostaglandin E(2) (PGE(2)) by rad…
Lyyrisyys suhteessa kerronnallisuuteen Ranya ElRamlyn romaanissa Auringon asema ja Saila Susiluodon proosarunoteoksessa Missä leikki loppuu
2015
Pro gradu -tutkielmani lähtökohtana on kirjallisuudentutkimuksen perustavanlaatuisimpia kysymyksiä: mitä on runous ja mikä on kertomus? Kartoitan tutkielmassani kirjallisuudentutkimuksen parissa esitettyjä käsityksiä siitä, mikä tekee runoudesta runoutta ja mistä kertomus muodostuu. Keskiöön nousee varsinkin käsitys lyyrisyydestä tekstin ominaisuutena pikemminkin kuin lajia määrittävänä piirteenä. Painoarvoa saa erityisesti lyyrisen vertailu kerronnalliseen: mitkä ovat lyyrisen ja kerronnallisen erottavia ominaisuuksia ja miten ne toimivat tekstissä suhteessa toisiinsa. Analyysin kohteina tutkielmassani toimivat Ranya ElRamlyn romaani Auringon asema ja Saila Susiluodon proosarunoteos Missä …
Event reconstruction in NEXT using a ML-EM algorithm
2017
La desintegración doble beta sin neutrinos es un proceso hipotético en el que dos neutrones de un núcleo se transforman en dos protones emitiendo únicamente dos electrones, sin neutrinos. La detección de un proceso así demostraría que los neutrinos son partículas de Majorana y que el número leptónico total no se conserva (las oscilaciones de neutrinos ya han demostrado que el número leptónico por familia no se conserva). La determinación de la naturaleza del neutrino podría responder a varias preguntas de diversa índole dentro de la física de partículas. Primero, podría dar explicación a la escala de masas del neutrino a través de un mecanismo de balancín (see-saw). Por…
Neural Classification of Compost Maturity by Means of the Self-Organising Feature Map Artificial Neural Network and Learning Vector Quantization Algo…
2019
Self-Organising Feature Map (SOFM) neural models and the Learning Vector Quantization (LVQ) algorithm were used to produce a classifier identifying the quality classes of compost, according to the degree of its maturation within a period of time recorded in digital images. Digital images of compost at different stages of maturation were taken in a laboratory. They were used to generate an SOFM neural topological map with centres of concentration of the classified cases. The radial neurons on the map were adequately labelled to represent five suggested quality classes describing the degree of maturation of the composted organic matter. This enabled the creation of a neural separator classify…
Noziedzīgi iegūto līdzekļu legalizācijas un terorisma finansēšanas novēršanas normatīvā regulējuma attīstība un problemātika Eiropas Savienībā
2020
Bakalaura darba “Noziedzīgi iegūto līdzekļu legalizācijas un terorisma finansēšanas novēršanas normatīvā regulējama attīstība un problemātika Eiropas Savienībā” mērķis ir izpētīt noziedzīgi iegūto līdzekļu legalizācijas un terorisma finansēšanas regulējumu Eiropas Savienības normatīvajos aktos un piedāvāt regulējuma uzlabojumus. Veicot dažādu avotu analīzi, autors ir nonācis pie secinājumiem, ka Eiropas Savienības regulējumā ir noteiktas pilnveidojuma iespējas trastiem pielīdzināmu personu, čaulas veidojumu, patiesā labumu guvēju identificēšanas un eksteritoriālā pilnvarojumu jomā. Autors piedāvā risinājumus, kā būtu iespējams uzlabot Eiropas Savienības regulējumu noziedzīgi iegūto līdzekļu…