Search results for "ML"
showing 10 items of 1465 documents
Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent…
2015
Summary Background Acute myeloid leukaemia mainly affects elderly people, with a median age at diagnosis of around 70 years. Although about 50–60% of patients enter first complete remission upon intensive induction chemotherapy, relapse remains high and overall outcomes are disappointing. Therefore, effective post-remission therapy is urgently needed. Although often no post-remission therapy is given to elderly patients, it might include chemotherapy or allogeneic haemopoietic stem cell transplantation (HSCT) following reduced-intensity conditioning. We aimed to assess the comparative value of allogeneic HSCT with other approaches, including no post-remission therapy, in patients with acute…
Mild phenotypes in a series of patients with Opitz GBBB syndrome with MID1 mutations
2004
Contains fulltext : 48815.pdf (Publisher’s version ) (Closed access) Opitz syndrome (OS; MIM 145410 and MIM 300000) is a congenital midline malformation syndrome characterized by hypertelorism, hypospadias, cleft lip/palate, laryngotracheoesophageal (LTE) abnormalities, imperforate anus, developmental delay, and cardiac defects. The X-linked form (XLOS) is caused by mutations in the MID1 gene, which encodes a microtubule-associated RBCC protein. In this study, phenotypic manifestations of patients with and without MID1 mutations were compared to determine genotype-phenotype correlations. We detected 10 novel mutations, 5 in familial cases, 2 in sporadic cases, and 3 in families for whom it …
DSM-IV Combined Type ADHD Shows Familial Association With Sibling Trait Scores
2008
Contains fulltext : 69060.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, u…
Pan-cancer analysis of whole genomes
2020
Publisher's version (útgefin grein)
Réécriture et reformulation des topiques descriptifs du ġazal homoérotique dans le Nasīm al-ṣabā (La brise du vent d’est) d’Ibn Ḥabīb al-Ḥalabī (m. 1…
2023
In his work entitled Nasīm al-ṣabā (The Breeze of the East Wind), Ibn Ḥabīb al-Ḥalabī (d. 1377) dedicates a chapter to the description of a young man (ġulām). This chapter is characterized by the presence of two parts which differ from a stylistic point of view. This paper deals with the central part of the chapter, which is entirely descriptive. The description of the ephebe in this central part shows great detail both descriptively (regarding the physical features of the ephebe) and thematically (regarding the topics used). In this part, the descriptive topics of the ephebe present in the classical homoerotic ġazal are transposed and reformulated in saǧ‘ (rhymed prose). A salient feature …
“Khubz as iqṭā' in four authors from the Ayyubid and early Mamluk period”
2012
Khubz as Iqta
Study regarding the influence of material type on economic objectives in MEx fabrication
2021
Material Extrusion has been used extensively as an additive manufacturing technology for a variety of applications like visual models, functional prototypes, tooling components, patterns for castings, and final parts. The current research paper proposes a study on the material type influence on economic objectives in material extrusion fabrication of complex assemblies. Three economic objectives have been analysed, namely, estimated fabrication time, material usage and material cost, whilst two commercial additive manufacturing machines have been considered for the simulation. Cura and ZSuite slicing software were used for the generation of Gcode and project files. Five filaments were selec…
Value creation in the international public procurement market: In search of springbok firms
2019
Abstract Public procurement accounts for more than 10% of global GDP. Digital transformation of public procurement creates new opportunities for value creation in international markets. Identifying and analyzing the companies, especially the SMEs, that can capitalize on these opportunities is therefore an important issue for policymaking, management, and scientific research. This study linked microdata on selected bidders from the Tenders Electronic Daily (TED) e-procurement portal and the Orbis database. Based on a sample of 933 Spanish companies, the analysis provides empirical support for the cross-border size bias conjecture. The reason for this bias is the predominance of large compani…
How risk influences the choice of governance mode in biopharmaceutical inter-firm relationships
2013
Abstract This paper proposes a new theoretical framework for assessing the influence of risk in shaping the governance form in biopharmaceutical inter-firm relationships. In particular, we propose a multidimensional operationalization of relational and performance risk and, by following Transaction Cost Economics (TCE) and Real Options (RO) theory constructs, we hypothesize a relation between the aforementioned risk components and the choice of governance form. Specifically, following TCE reasoning, we hypothesize that a high level of relational risk leads towards more hierarchical governance forms, while, following RO theory, we hypothesize that a high level of performance risk leads towar…
Enforcing mobile security with location-aware role-based access control
2013
This paper describes how location-aware role-based access control RBAC can be implemented on top of the Geospatial eXtensible Access Control Markup Language GeoXACML. It furthermore sketches how spatial separation of duty constraints both static and dynamic can be implemented using GeoXACML on top of the XACML RBAC profile. The solution uses physical addressing of geographical locations, which facilitates easy deployment of authorisation profiles to the mobile device. Location-aware RBAC can be used to implement location-dependent access control and also other security enhancing solutions on mobile devices, such as location-dependent device locking, firewall, intrusion prevention or payment…