Search results for "MODY"
showing 10 items of 4576 documents
Collimation of energy in medium-modified QCD jets
2012
The collimation of energy inside medium-modified jets is investigated in the leading logarithmic approximation of QCD. The Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) evolution equations are slightly modified by introducing splitting functions enhanced in the infrared sector. As compared to elementary collisions in the vacuum, the angular distribution of the jet energy is found to broaden in QCD media.
Veden käyttö korkean lämpötilan kylmähöyryprosessin kiertoaineena
2012
MODY ģenētisko riska faktoru analīze Latvijas populācijā
2019
MODY sastāda 1-5 % no visiem cukura diabēta gadījumiem, taču diagnoze nereti tiek uzstādīta kļūdaini. Izmantojot uz NGS balstītu MODY gēnu sekvencēšanu, patogēnus alēliskos variantus identificēja 21 no 78 testētajiem, MODY fenotipam atbilstošiem pacientiem. Identificētie varianti atbilst MODY2/GCK (n=15), MODY3/HNF1α (n=5) un MODY8/CEL (n=1) tipiem, turklāt patogēno variantu pārmantošana tika apstiprināta septiņās ģimenēs. MODY kandidātgēnu lokusu analīze atklāja 22 biežo variantu asociāciju ar 2. tipa cukura diabēta attīstību, 201 varianta saistību ar 2. tipa cukura diabēta saslimšanas vecumu, 17 variantu saistību ar 1. tipa cukura diabēta saslimšanas vecumu un 41 varianta saistību ar 1. t…
Report from Working Group 5: Future physics opportunities for high-density QCD at the LHC with heavy-ion and proton beams
2019
The future opportunities for high-density QCD studies with ion and proton beams at the LHC are presented. Four major scientific goals are identified: the characterisation of the macroscopic long wavelength Quark-Gluon Plasma (QGP) properties with unprecedented precision, the investigation of the microscopic parton dynamics underlying QGP properties, the development of a unified picture of particle production and QCD dynamics from small (pp) to large (nucleus--nucleus) systems, the exploration of parton densities in nuclei in a broad (x, Q2) kinematic range and the search for the possible onset of parton saturation. In order to address these scientific goals, high-luminosity Pb-Pb and p-Pb p…
Specific heat of thin phonon cavities at low temperature: Very high values revealed by zeptojoule calorimetry
2022
The specific heat of phonon cavities is investigated in order to analyze the effect of phonon confinement on thermodynamic properties. The specific heat of freestanding very thin SiN membranes in the low-dimensional limit is measured down to very low temperatures (from 6 K to 50 mK). In the whole temperature range, we measured an excess specific heat orders of magnitude bigger than the typical value observed in amorphous solids. Below 1 K, a crossover in cp to a lower power law is seen, and the value of the specific heat of thinner membranes becomes larger than that of thicker ones demonstrating a significant contribution coming from the surface. We show that this high value of the specific…
Yielding of a quartz sand from saturated to dry state
2020
The paper presents the results of an experimental work where we analyse the behaviour of an unsaturated quartz sand in a wide range of degree of saturation (from saturated to dry state). The possibility of anticipating the hydro-mechanical behaviour of the soils when they approach the dry state is fundamental in many areas. An extensive experimental program, including controlled-suction and constant water content oedometric tests, was carried out to deeply analyse the water retention behaviour and the relationship between the yield stress and suction (Loading-Collapse curve). All elasto-plastic models provide a monotonically increase of the yield stress with suction. This assumption implies…
A physical model for the interaction between unsaturated soils and retaining structures
2020
Temporary and permanent retaining structures interact with soils that are usually in unsaturated conditions. In this work, a 1g-scale physical model is presented to investigate the interactions between retaining walls and unsaturated soils. The physical model is equipped with a water-filled hydraulic cylinder connected to a pressure-volume controller to measure the horizontal component of the later earth thrust and high capacity tensiometers to measure soil matric suction. A system of low-friction linear guideways has been installed at the base of the wall-model. The failure surface is observed through a 3 cm thick glass wall on one side of the container. A series of images are acquired dur…
Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…
Erratum: Mangas-Sanjuán, V.; et al. Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the De…
2020
Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was to compare the microstructure-defining physical parameters of different batches of a reference ointment containing calcipotriol and betamethasone (Daivobet 50 µg/0.5 mg/g) in order to define the acceptance range that allows concluding equivalence between these batches. Being batches of the same reference product, they are expected to be clinically equivalent and possess similar microstructure. The 90% confidence intervals for the test/reference ratio of these physical parameters …
Volume Changes in Filled Rubber Under Uniaxial Cyclic Loading
2011
Styrene-butadiene rubber, neat and filled with different silica content was investigated under uniaxial cyclic loading under a constant crosshead speed, with increasing deformation amplitude in subsequent loading cycles. Rubber was investigated in order to evaluate the reversibility of structure rearrangements, occurring in rubber when subjected to cyclic loading. Volume uniformly increases with growing strain and shows hysteresis at unloading. After complete unloading, no residual strain changes are observed. These data are in good conformity with the data of density measurements, which were made on specimens before and after the tests. By correlating data, obtained from volume changes and…