Search results for "MORBIDITY"

showing 10 items of 986 documents

Physical multimorbidity predicts the onset and persistence of anxiety: A prospective analysis of the Irish Longitudinal Study on Ageing.

2022

Background: The aims of the present study were to examine prospective associations of multimorbidity (i.e., >= 2 chronic conditions) at baseline with incident and persistent anxiety over a two-year follow-up period among Irish older adults, and to quantify the extent to which sleep, pain, and disability mediate the multimorbidity-anxiety relationship.& nbsp;Methods: Data from The Irish Longitudinal Study on Aging (TILDA) conducted between 2009 and 2011 with a follow-up after two years were analyzed. Anxiety referred to score >=& nbsp;8 on the anxiety section of the Hospital Anxiety and Depression Scale. Lifetime diagnosis of 14 chronic conditions was obtained. Outcomes were in…

MaleAgingA prospective analysis of the Irish Longitudinal Study on Ageing.- Journal of affective disorders 2022 [Smith L. Shin J. I. Jacob L. Schuch F. Pizzol D. López Sánchez G. F. Soysal P. Tully M. A. Butler L. T. Barnett Y. et al. -Physical multimorbidity predicts the onset and persistence of anxiety]MultimorbidityPainAnxietyPsychiatry and Mental healthClinical PsychologyChronic DiseaseHumansFemaleAnxiety Cohort Epidemiology Multimorbidity Older adultsLongitudinal StudiesAged
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Intraocular Pressure Telemetry for Managing Glaucoma during the COVID-19 Pandemic

2021

Purpose To evaluate in glaucoma patients the feasibility and use of remote monitoring of intraocular pressure (IOP) with an implanted telemetry sensor during the coronavirus disease 2019 (COVID-19) lockdown. Design Cross-sectional study. Participants Patients previously implanted with a telemetric IOP sensor (Eyemate; Implandata GmbH) were included. Methods Intraocular pressure measurements acquired by the patients during the lockdown were collected by physicians who were located remotely. A questionnaire was sent to 10 participating study centers to evaluate the clinical impact of remote monitoring of IOP via the IOP sensor system. Main Outcome Measures Number of patients who obtained home…

MaleAgingIntraocular pressuregenetic structuresCross-sectional studyIntraocular pressureOffice visitsGlaucomaComorbidityNeurodegenerative01 natural sciences0302 clinical medicineTelemetryTelemetryProspective StudiesProspective cohort studyCOVID-19 coronavirus disease 2019Sensor systemInfectiousGeneral MedicineEquipment DesignMiddle AgedFemaleSwitzerlandmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)MonitoringClinical Trials and Supportive ActivitiesBioengineeringTonometry03 medical and health sciencesTonometry OcularDisease TransmissionClinical ResearchOcularOphthalmologyLockdownmedicineDisease Transmission InfectiousHumans0101 mathematicsEye Disease and Disorders of VisionPandemicsbusiness.industrySARS-CoV-2IOP010102 general mathematicsNeurosciencesCOVID-19Glaucomamedicine.diseaseIOP intraocular pressureeye diseasesFull-length articles and Review articlesUnited KingdomCross-Sectional Studies030221 ophthalmology & optometrysense organsbusinessFollow-Up StudiesOphthalmology. Glaucoma
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Are changes in pain, cognitive appraisals and coping strategies associated with changes in physical functioning in older adults with joint pain and c…

2019

Background As the population ages, the number of people with chronic diseases increases. Frequently, older people suffer from joint pain together with other chronic diseases, which can lead to decreased physical functioning. Aims To investigate the associations of the changes in cognitive appraisals, coping strategies and pain with the change in physical functioning in older people, who have chronic pain and chronic diseases. Methods Elderly persons (n = 407, mean age 77 years, and 62% female), with self-reported joint pain and at least two chronic diseases, filled in questionnaires about cognitive appraisals, coping strategies, pain intensity and physical functioning at baseline, at 6- and…

MaleAgingPopulationfyysinen toimintakykyComorbiditycoping strategiesGee03 medical and health sciences0302 clinical medicineCognitionPhysical functioningAdaptation PsychologicalMedicineHumans030212 general & internal medicineeducationkrooniset tauditGeneralized estimating equationolder adultsAgedcognitive appraisalseducation.field_of_studybusiness.industryselviytyminenChronic painkipuCognitionPhysical Functional Performancemedicine.diseaseComorbidityArthralgiaJoint painChronic Diseasekrooninen kipuFemaleGeriatrics and Gerontologymedicine.symptombusiness030217 neurology & neurosurgeryikääntyneetClinical psychologyAging Clinical and Experimental Research
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Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19.

2020

Abstract Background the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients. Methods post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65–74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality. Results about, 1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71–83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), card…

MaleAgingmedicine.medical_specialtyInternational CooperationPopulation030204 cardiovascular system & hematologycomorbiditiesRisk Assessment03 medical and health sciencesAcademicSubjects/MED002800302 clinical medicineRisk FactorsInternal medicineEpidemiologymedicineClinical endpointDementiaHumans030212 general & internal medicineHospital MortalityRegistriesMortalityeducationGeriatric Assessmentolder adultsAgedAged 80 and overeducation.field_of_studyCoronavirus disease 2019business.industrySARS-CoV-2COVID-19MultimorbidityGeneral Medicinemedicine.diseasePrognosisComorbidityHospitalizationAgeingIntensive Care UnitsRespiratory failureHeart failureFemaleGeriatrics and GerontologybusinessDyslipidemiaResearch PaperAge and ageing
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Hyperuricemia, cardiovascular profile, and comorbidity in older men and women: The Pro.V.A. Study

2017

Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes. Pro.V.A. is a survey of 3099 individuals aged 65+, focusing on chronic diseases and disability. Uric acid (UA) levels were dichotomized using 6.0 mg/dL (females) and 7.0 mg/dL (males), and multivariate logistic regression models were used to estimate odds ratios (ORs) between HU and single comorbidity. HU prevalence was 21.5% in females and 15.8% in males. HU was associated wi…

MaleAgingmedicine.medical_specialtyPrevalenceComorbidityHyperuricemia030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineInternal medicineEpidemiologymedicineOdds RatioPrevalenceHumansHyperuricemiaLife StyleAged030203 arthritis & rheumatologyAnthropometrybusiness.industryCase-control studyOdds ratioAnthropometrymedicine.diseaseComorbidityUric AcidLogistic ModelsItalyCardiovascular DiseasesCase-Control StudiesPhysical therapyFemalecardiovascular diseases comorbidity elderly gender hypertension hyperuricemiaGeriatrics and GerontologybusinessBody mass index
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Peripheral arterial disease, diabetes and postural balance among elderly Finns: a population-based study

2008

Background and aims: Little is known about the role of peripheral arterial disease (PAD)in the development of balance impairment. The aim of this study was to assess postural balance among people having PAD or PAD combined with diabetes. Methods: As part of the comprehensive health examination of the Health 2000 survey (two-stage stratified cluster sampling), 1323 people aged 65 years or older took part in balance assessments using a force platform system. The presence of PAD was confirmed with data from the National Hospital Discharge Registry. Individuals with hospitalization due to PAD were regarded as having severe disease, whereas those with solely self-reported diagnosis were consider…

MaleAgingmedicine.medical_specialtyPsychological interventionPhysical examinationComorbidityDiseaseDiabetes ComplicationsAge DistributionRisk FactorsInternal medicineStatistical significanceDiabetes mellitusmedicinePostural BalanceHumansForce platformPostural BalanceFinlandAgedAged 80 and overPeripheral Vascular Diseasesmedicine.diagnostic_testbusiness.industrymedicine.diseaseComorbidityLogistic ModelsPhysical therapyFemaleGeriatrics and GerontologybusinessAging Clinical and Experimental Research
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Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative

2016

Background: osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. Objective: to determine whether OA was associated with an increased odds of developing depressive symptoms. Design: longitudinal cohort study (follow-up: 4.2 years). Setting: data were gathered from the North American Osteoarthritis Initiative (OAI) dataset. Subjects: people at higher risk developing OA. Methods: OA diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defin…

MaleAgingmedicine.medical_specialtyTime FactorsComorbidityOsteoarthritisLogistic regressionOsteoarthritis HipOdds03 medical and health sciences0302 clinical medicineRisk FactorsSurveys and QuestionnairesInternal medicineEpidemiologyOdds RatiomedicineHumansLongitudinal StudiesProspective Studies030212 general & internal medicineosteoarthritis depression depressive symptoms epidemiology older peopleDepression (differential diagnoses)Aged030203 arthritis & rheumatologyChi-Square DistributionDepressionbusiness.industryIncidenceIncidence (epidemiology)ConfoundingGeneral MedicineOdds ratioMiddle AgedOsteoarthritis Kneemedicine.diseaseUnited StatesLogistic ModelsMental HealthMultivariate AnalysisPhysical therapyFemaleGeriatrics and GerontologybusinessAge and Ageing
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The mini nutritional assessment is associated with the perception of dyspnoea in older subjects with advanced COPD

2008

MaleAgingmedicine.medical_specialtymedia_common.quotation_subjectComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioRisk AssessmentSeverity of Illness IndexStatistics NonparametricCohort StudiesPulmonary Disease Chronic ObstructiveAge DistributionPhysical medicine and rehabilitationSurveys and QuestionnairesPerceptionSeverity of illnessmedicineHumansSex DistributionAgedProbabilitymedia_commonCOPDAnthropometrybusiness.industryIncidenceIncidence (epidemiology)General MedicineMiddle AgedAnthropometryPrognosismedicine.diseaseSurvival AnalysisComorbidityNutrition DisordersDyspneaNutrition AssessmentPhysical therapyFemalePerceptionBasal MetabolismGeriatrics and GerontologyRisk assessmentbusinessCohort studyDyspnea/diagnosis/*epidemiology
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Older persons with signs of frailty in a home-based physical exercise intervention : baseline characteristics of an RCT

2019

Background Increasing the level of physical activity among persons with signs of frailty improves physical functioning. There is a lack of long-term supervised physical exercise intervention studies including a validated definition of frailty. Aims To present baseline characteristics of persons with signs of frailty participating in a randomized long-term home-based physical exercise trial (HIPFRA), and to study associations between the severity of frailty, functional independence and health-related quality-of-life (HRQoL). Methods Three hundred persons, ≥ 65 years old and with signs of frailty (assessed by Fried´s phenotype criteria) were recruited from South Karelia, Finland and randomize…

MaleAgingvanhuksetelämänlaatulaw.invention0302 clinical medicineQuality of lifeRandomized controlled trialDESIGNlawQUALITY-OF-LIFEMedicine030212 general & internal medicine10. No inequalityFinlandAged 80 and overgerasteniaFrailtyexerciseFunctional Independence Measure3142 Public health care science environmental and occupational healthExercise TherapyBaseline characteristicsCommunity-dwelling older peopleFemalehealth-related quality-of-lifeliikuntahoitomedicine.medical_specialtyhyvinvointi (terveydellinen)RandomizationFrail ElderlykotihoitoPhysical exercisefrailtyHealth-related quality-of-life03 medical and health sciencesMORBIDITYvammaisuusPEOPLEIntervention (counseling)HumansDisabled PersonsExerciseAgedDisabilitybusiness.industryADULTSHome basedPhysical therapyQuality of LifeGeriatrics and Gerontologybusinesscommunity-dwelling older peoplehuman activities030217 neurology & neurosurgery
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