Search results for "MOS"

Acute Effect of Alcohol Intake on Cardiovascular Autonomic Regulation During the First Hours of Sleep in a Large Real-World Sample of Finnish Employe…

2018

Background Sleep is fundamental for good health, and poor sleep has been associated with negative health outcomes. Alcohol consumption is a universal health behavior associated with poor sleep. In controlled laboratory studies, alcohol intake has been shown to alter physiology and disturb sleep homeostasis and architecture. The association between acute alcohol intake and physiological changes has not yet been studied in noncontrolled real-world settings. Objective The aim of this study was to assess the effects of alcohol intake on the autonomic nervous system (ANS) during sleep in a large noncontrolled sample of Finnish employees. Methods From a larger cohort, this study included 4098 su…

Inhibition of the NF-κB Signaling Pathway Mediates the Anti-inflammatory Effects of Petrosaspongiolide M

2003

Petrosaspongiolide M (PT) is a potent secretory phospholipase A(2) inhibitor and anti-inflammatory agent. This marine metabolite reduced the production of nitrite, prostaglandin E(2), and tumor necrosis factor-alpha in the mouse air pouch injected with zymosan. These effects were also observed in mouse peritoneal macrophages stimulated with zymosan. Inhibition of these inflammatory mediators was related to reductions in inducible nitric oxide synthase, cyclo-oxygenase-2, and tumor necrosis factor-alpha expression. Since nuclear factor-kappaB (NF-kappaB) appears to play a central role in the transcriptional regulation of these proteins by macrophages, we investigated the effects of PT on thi…

A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase

2002

Abstract In a previous study, we reported a new pyrroloquinazoline derivative, 3-(4′-acetoxy-3′,5′-dimethoxy)benzylidene-1,2-dihydropyrrolo[2,1- b ]quinazoline-9-one (PQ), which inhibited human purified 5-lipoxygenase activity and prostaglandin E 2 release in lipopolysaccharide-stimulated RAW 264.7 cells. In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity. This behaviour was confirmed in vivo by using the zymosan-injected mouse air pouch model, where PQ caused a marked reduction in cell migration and leukotriene B 4 levels at 4 h, as …

Cell-Free Fetal DNA and Non-Invasive Prenatal Diagnosis of Chromosomopathies and Pediatric Monogenic Diseases: A Critical Appraisal and Medicolegal R…

2022

Cell-free fetal DNA (cffDNA) analysis is a non-invasive prenatal diagnostic test with a fundamental role for the screening of chromosomic or monogenic pathologies of the fetus. Its administration is performed by fetal DNA detection in the mother’s blood from the fourth week of gestation. Given the great interest regarding its validation as a diagnostic tool, the authors have set out to undertake a critical appraisal based on a wide-ranging narrative review of 45 total studies centered around such techniques. Both chromosomopathies and monogenic diseases were taken into account and systematically discussed and elucidated. Not surprisingly, cell-free fetal DNA analysis for screening purposes …

Percorrendo il Bestiario. La rappresentazione del mondo animale nei pavimenti musivi del Medioevo veneziano

2019

Madonna Haghiosorìtissa oder der Fürsprache (scheda F 6_8)

2022

L'opera d'arte, oggi al Museo Diocesano di Palermo, è un mosaico staccato del XII secolo forse proveniente dalla cappella di Santa Maria Maddalena nella Cattedrale, dove erano sepolti i membri della famiglia Hauteville, voluta dalla regina Elvira The work of art, now in the Diocesan Museum in Palermo, is a detached 12th century mosaic possibly from the chapel of Saint Mary Magdalene in the Cathedral, where members of the Hauteville family were buried, commissioned by Queen Elvira Bei dem Kunstwerk, das sich heute im Diözesanmuseum in Palermo befindet, handelt es sich um ein freistehendes Mosaik aus dem 12. Jahrhundert, das möglicherweise aus der Kapelle der Heiligen Maria Magdalena in der K…

Descubriendo nuevos antibióticos producidos por bacterias del suelo

2019

El abuso y/o uso inadecuado de antibióticos es actualmente un grave problema en nuestra sociedad que hace que los microorganismos adquieran resistencias frente a estos compuestos antimicrobianos. Estas resistencias son debidas a la presión de selección que ejercemos sobre los microorganismos, lo que dificulta el tratamiento de las enfermedades que causan algunos de ellos. Por lo tanto, se hace necesario la búsqueda de nuevos antibióticos mediante distintas estrategias, siendo una de ellas la relacionada con la participación ciudadana. El objetivo principal del presente proyecto, basado en una estrategia de Aprendizaje-Servicio (ApS), se ha centrado en la realización de una propuesta educati…

Shortwave Ultraviolet Persistent Luminescence of Sr2MgSi2O7: Pr3+

2023

Currently, extensive research activities are devoted to developing persistent phosphors which extend beyond the visible range. In some emerging applications, long-lasting emission of high-energy photons is required; however, suitable materials for the shortwave ultraviolet (UV–C) band are extremely limited. This study reports a novel Sr2MgSi2O7 phosphor doped with Pr3+ ions, which exhibits UV–C persistent luminescence with maximum intensity at 243 nm. The solubility of Pr3+ in the matrix is analysed by X-ray diffraction (XRD) and optimal activator concentration is determined. Optical and structural properties are characterised by photoluminescence (PL), thermally stimulated lumi…

Shared socioeconomic pathways for climate change research in Finland: co-developing extended SSP narratives for agriculture

2021

AbstractShared socioeconomic pathways (SSPs), developed at global scale, comprise narrative descriptions and quantifications of future world developments that are intended for climate change scenario analysis. However, their extension to national and regional scales can be challenging. Here, we present SSP narratives co-developed with stakeholders for the agriculture and food sector in Finland. These are derived from intensive discussions at a workshop attended by approximately 39 participants offering a range of sectoral perspectives. Using general background descriptions of the SSPs for Europe, facilitated discussions were held in parallel for each of four SSPs reflecting very different c…

Flussi di evasione marina del mercurio elementare gassoso (Hg0) nell’atmosfera della Rada di Augusta

2015

Il mercurio (Ilg) è uno dei principali inquinanti emessi in atmosfera. La sua complessità geochimica, unitamente alla tossicità c agli effetti persistenti della sua presenza nell’ecosistema terrestre, lo hanno inserito nella lista delle priorità di un numero sempre crescente di accordi internazionali rivolti alla tutela ambientale e della stiline umana (The Arctic- Monitoring and Assessment Program, AMAR, United Nations - Economie Commission for Europe: Ileavy Metals Protocol, UN- ECE, The Helsinki Commission, IIELCOM, la convenzione OSPAR). I progressi raggiunti neH’ullimo decennio sullo studio del Hg come ‘global poi Intani '(Pirrone et al.. 2001; Hedgecock et al, 2000: Paeyna et al, 2006…