Search results for "MOTILITY"
showing 3 items of 303 documents
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
An experimental approach to oxidative stress effect on sperm motility and DNA fragmentation
2018
En el estudio de la fertilidad masculina en todas las especies animales, la movilidad espermática, junto a la concentración y morfometría son los parámetros principales y más básicos en la evaluación de la calidad de los espermatozoides. La infertilidad masculina habitualmente se asocia con tasas anormales de estos parámetros seminales. Aún teniendo, los espermatozoides tasas adecuadas de todos estos parámetros no se puede garantizar la capacidad de fertilizar y/o desarrollar un cigoto. Por lo tanto, está claro que el examen rutinario del semen y los espermatozoides en la eyaculación no puede evaluar otros parámetros importantes en el proceso de fecundación como es capacitación espermática …
Regulation of motility of cells from marine sponges by calcium ions
1996
Sponges are known not to contain muscle and nerve cells. Since sponge cells are characterized by high motility we determined the effect of intracellular calcium ion concentration ([Ca2+]i) on their motility. Addition of the Ca2+ ionophore ionomycin to dissociated cells from the marine sponge Suberites domuncula caused in Ca(2+)-containing artificial seawater (ASW) an increase in motility from 0.2 micron/min (absence of the ionophore) to 3.7 microns/min (presence of ionomycin). When the experiments were performed in Ca(2+)-free medium, no effect of ionomycin could be observed. In parallel experiments the changes of [Ca2+]i using the dye Fura-2 were measured. The experiments revealed that ion…