Search results for "MOZ"
showing 10 items of 437 documents
Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT pr…
2019
Summary Background There is an urgent need for more effective therapies for glioblastoma. Data from a previous unrandomised phase 2 trial suggested that lomustine-temozolomide plus radiotherapy might be superior to temozolomide chemoradiotherapy in newly diagnosed glioblastoma with methylation of the MGMT promoter. In the CeTeG/NOA-09 trial, we aimed to further investigate the effect of lomustine-temozolomide therapy in the setting of a randomised phase 3 trial. Methods In this open-label, randomised, phase 3 trial, we enrolled patients from 17 German university hospitals who were aged 18–70 years, with newly diagnosed glioblastoma with methylated MGMT promoter, and a Karnofsky Performance …
African, southern Indian and South American cratons were not part of the Rodinia supercontinent: evidence from field relationships and geochronology
2003
We discuss the question whether the late Mesoproterozoic and early Neoproterozoic rocks of eastern, central and southern Africa, Madagascar, southern India, Sri Lanka and South America have played any role in the formation and dispersal of the supercontinent Rodinia, believed to have existed between about 1000 and 750 Ma ago. First, there is little evidence for the production of significant volumes of ~1.4–1.0 Ga (Kibaran or Grenvillian age) continental crust in the Mozambique belt (MB) of East Africa, except, perhaps, in parts of northern Mozambique. This is also valid for most terranes related to West Gondwana, which are made up of basement rocks older than Mesoproterozoic, reworked in th…
Inherited semisterility for control of harmful insects. II. Degree of sterility and types of translocations in the mosquito Culex pipiens L.
1971
Fur die Anwendung von Semisterilitat infolge von Translokationen zur Bekampfung schadlicher Insekten ist der Grad der Semisterilitat und die Art der zugrundeliegenden Translokation von Bedeutung. Von den bisher untersuchten 124 Translokationen hatten 101 einen Sterilitatsgrad zwischen 10 und 50%, 23 uber 50 bis zu 85%. Mit dem mannlichen Geschlechtsfaktor M gekoppelte Translokationen sind zur Zeit die fur die Praxis am nutzlichsten. Sie treten nicht so haufig auf als erwartet, machen aber doch rund 1/4 aller getesteten Translokationen aus. Es werden Grunde angefuhrt, weshalb M-gekoppelte Translokationen nutzlicher sind.
460. MGMTP140K Vector Constructs for Efficient In Vivo Enrichment of Genetically Corrected Cells Following Hematopoietic Cell Gene Transfer
2006
MGMTP140K, a mutant of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) resistant to the inhibitor O6-benzylguanine (BG), protects hematopoietic stem cells (HSC) from the toxicity of alkylating agents such as temozolomide (TMZ) and, therefore, allows efficient in vivo enrichment of transduced cells by BG/TMZ therapy. MGMTP140K has been proposed as a selection marker in gene therapy of monogeneic diseases. If used for this purpose, however, MGMTP140K expression in vectors containing internal ribosomal entry sites (IRES) would be from the compromised 3' position, as the 5' position will be required for the therapeutic gene. Thus, we have investigated SFFV/MESV-based vector…
Del bene
2021
Del bene sembra che nel nostro tempo, segnato dal pluralismo etico e spesso dal nichilismo assiologico, non abbia alcun senso parlare. Di più: sembra che non se ne debba parlare per rispettare la libertà di tutti. Il testo presenta un’analisi fenomenologica del concetto di bene tesa a mostrare la vacuità di queste presupposizioni, ma anche i fattori di rischio per l’educazione contemporanea insiti in esse. Attraverso una ripresa dell’etica di E. Husserl e di alcuni dei suoi allievi, temi cruciali per una filosofia dell’educazione adeguata al nostro tempo sono allora: la differenza tra l’utile e il bene, il ruolo delle emozioni nella vita morale, il nesso tra desiderio, volontà e scelta, la …
Genome‐wide survey on three local horse populations with a focus on runs of homozygosity pattern
2022
Purosangue Orientale Siciliano, Sanfratellano and Siciliano represent the Sicilian equine genetic resource. This study aimed to investigate the genetic diversity, population structure and the pattern of autozygosity of Sicilian horse populations using genome-wide single-nucleotide polymorphism (SNP) data generated with the Illumina Equine SNP70 array. The genotyping data of 17 European and Middle East populations were also included in the study. The patterns of genetic differentiation, model-based clustering and Neighbour-Net showed the expected positioning of Sicilian populations within the wide analysed framework and the close connections between the Purosangue Orientale Siciliano and the…
Zircon geochronology of anatectic melts and residues from a highgrade pelitic assemblage at Ihosy, southern Madagascar: evidence for Pan-African gran…
1996
AbstractWe report U—Pb and207Pb/206Pb zircon ages for a granulite facies gneiss assemblage exposed in a large quarry at Ihosy, southern Madagascar. The granulites are derived from pelitic to arkosic sediments and attained equilibrium conditions at 650–700°C and 4–5 kbar. HigherP—Tconditions of 750–800°C and 6 kbar in the presence of low water activities have led to dehydration melting processes. The formation of granitic melts, which (partly) moved away from their source region, intruded into upper parts of the metapelitic gneisses as small granitic veins and left behind granulitic garnet-cordierite-quartz bearing rocks. Detrital zircons in a sample of metapelite and a sample of quartzofeld…
African linkage of Precambrian Sri Lanka
1991
New age and isotopic data show that the high-grade basement rocks of Sri Lanka were not linked to the Archaean granulite domain of southern India but experienced their main structural and metamorphic development during the Pan-African event some 950 to 550 Ma ago. This occurred when West Gondwana and East Gondwana collided to form one of the longest collisional structures in the Supercontinent — the Mozambique belt that extends from Mozambique to Ethiopia and Sudan. A major tectonic boundary, interpreted as a thrust zone, divides the Highland/Southwestern Complex in the central part of Sri Lanka from the Vijayan Complex in the E and SE. The former is interpreted to represent the remnant of …
Percorsi pedagogici nelle attività di prevenzione delle dipendenze patologiche
2019
La salute è un bene che va mantenuto e conservato; in tale attività, un ruolo chiave è svolto dagli interventi educativi specificamente orientati ad essa e dalla promozione di corretti stili di vita. Nel corso degli anni, la promozione della salute ha individuato nella scuola il luogo privilegiato per attuare interventi educativi in grado di produrre cambiamenti sugli atteggiamenti e sui comportamenti orientati a migliorare lo stato di benessere e prevenire comportamenti a rischio. In tal senso la scuola necessita della collaborazione con il mondo sanitario per predisporre un percorso educativo altamente consapevole e responsabile. La seconda parte del volume è infatti dedicata agli interve…
Promuovere la salute nella comunità. Elementi di pedagagia sanitaria
2010
L’opera proposta si pone come una rilettura di alcuni eventi comunitari ed analizza alcuni rilevanti momenti di patologia sociale associati alle diverse età della vita – i minori, la coppia, la famiglia, gli anziani - visti nel loro contesto di costruzione di benessere o di malessere. Il volume per contenuti e obiettivi si colloca sia nell’ambito delle scienze della salute sia nell’ambito delle scienze pedagogiche interdisciplinarietà che consente di approfondire gli aspetti diversi dei temi affrontati. La messa di dati raccolta è uno stimolo ad una presa di coscienza che porti ad una “diagnosi di comunità” e proponga soluzioni educative, economiche, sociali e ambientali.