Search results for "MOZ"
showing 10 items of 437 documents
Hipercolesterolemia familiar homocigota: adaptación a España del documento de posición del grupo de consenso sobre hipercolesterolemia familiar de la…
2015
Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening disease characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). The Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society (EAS) has recently published a clinical guide to diagnose and manage HoFH (Eur Heart J. 2014;35:2146-57). Both the Spanish Society of Atherosclerosis (SEA) and Familial Hypercholesterolaemia Foundation (FHF) consider this European Consensus document of great value and utility. However, there are particularities in our country which advise to ha…
Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits.
1998
Abstract —Low-density lipoprotein (LDL) can be transformed to an atherogenic moiety by nonoxidative, enzymatic degradation. Enzymatically degraded LDL induces macrophage foam cell formation, provokes release of cytokines, and also activates complement. To determine whether complement activation may contribute to atherogenesis, 6 pairs of homozygous C6-deficient rabbits and their non–C6-deficient heterozygous siblings were fed a cholesterol-rich diet for 14 weeks. Cholesterol levels and plasma lipoprotein profiles of the animals in the C6-competent and C6-deficient groups did not significantly differ, and the high density lipoprotein and LDL cholesterol ratios at the end of the experiment w…
Long-term efficacy of lipoprotein apheresis and lomitapide in the treatment of homozygous familial hypercholesterolemia (HoFH): a cross-national retr…
2021
Abstract Background Homozygous familial hypercholesterolemia (HoFH) is a rare life-threatening condition that represents a therapeutic challenge. The vast majority of HoFH patients fail to achieve LDL-C targets when treated with the standard protocol, which associates maximally tolerated dose of lipid-lowering medications with lipoprotein apheresis (LA). Lomitapide is an emerging therapy in HoFH, but its place in the treatment algorithm is disputed because a comparison of its long-term efficacy versus LA in reducing LDL-C burden is not available. We assessed changes in long-term LDL-C burden and goals achievement in two independent HoFH patients’ cohorts, one treated with lomitapide in Ita…
Neonatal Respiratory Insufficiency Caused by an (Homozygous) ABCA3-Stop Mutation: a Systematic Evaluation of Therapeutic Options
2014
Background Autosomal recessive ABCA3 (ATP-binding cassette protein A3) gene mutations have been associated with neonatal respiratory distress and pediatric interstitial lung disease. The clinical course of the disease depends on the underlying mutations. Therefore, knowledge of course, symptoms and treatment of the disease is important. Patient and methods A term newborn suffered from progressive respiratory insufficiency, which led to death at the age of 4.8 months. The girl developed interstitial lung disease. Infections as well as structural and functional disorders of the lung were systematically excluded. A homozygous c.4681C > T (Arg 1561 Stop) mutation of the ABCA3 gene was identifie…
Vicente Llorens, la discontinuidad cultural y la recuperación del arte del exilio
2022
Este artículo rescata la faceta más artística de Vicente Llorens que surgió tras entrar en contacto con los artistas del exilio, también fue coleccionista y visitante de museos. Comenzó con la organización de exposiciones y concluyó con la reconstrucción del discurso artístico de la diáspora republicana. Una de sus principales líneas de trabajo fue la discontinuidad de la cultura española. En su afán por reconstruirla para dar testimonio de quiénes fueron los intelectuales exiliados tras la Guerra Civil, su trabajo se convirtió en el punto de referencia de estudios artísticos posteriores.
La biodiversità microbica in relazione ad alcune produzioni della regione Umbria: formaggio pecorino e mozzarella fior di latte
2006
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA b…
2002
The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated. These combine the deficiency of CSB with that of OGG1, a gene coding for the mammalian repair glycosylase that initiates the base excision repair of 7,8-dihydro-8-oxoguanine (8-oxoG). Compared to ogg1(-/-) mice, csb(-/-)/ogg1(-/-) mice were found to accumulate with age severalfold higher levels of oxidited purine modifications in hepatocytes, splenocytes and kidney cells. In contrast, the basal (ste…
Una nuova spia della composita facies culturale e linguistica della Palermo normanna
2014
L'interpretazione del nome di una strada della Palermo normanna conferma uno scenario, già noto e di grande interesse, in cui musulmani ebrei e cristiani vivevano insieme a dispetto delle loro diverse culture e religioni. In quel periodo irripetibile della storia siciliana la comunità cristiana praticava peraltro la propria religione adottando vari riti. La presenza dei riti bizantino e gallicano nella Sicilia normanna era già nota. L'articolo mostra che ne va aggiunto un terzo, l'ispanico. Quest'ultimo era adottato dal gruppo di mozarabi arrivati dalla penisola iberica già durante la dominazione araba.
A novel technique for opus vermiculatum mosaic rendering
2006
In this paper we present a method to generate a digital mosaic starting from a raster input image. Mosaics generation of artistic quality is challenging. The basic elements, the tiles, typically small polygons, must be packed tightly, emphasizing orientations chosen by the artist. An adhoc boundaries detection have to be performed according to the directional guidelines. Different mosaic styles can be automatically rendered, depending on artistic techniques considered (“opus musivum”, “opus vermiculatum”, etc.). The proposed method is able to reproduce the colors of the original image emphasizing relevant boundaries by placing tiles along their direction. The boundaries detection is based o…