Search results for "MP2"

showing 5 items of 35 documents

Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex.

2005

Calcitonin gene-related peptide (CGRP) plays an important role in the mediation of protective effects observed in situations such as ischemic preconditioning in rat hearts. In this study, we investigated in H9c2 rat cardiomyoblasts if the protective effect of CGRP could be linked to an inhibitory effect on the apoptotic pathway. We also determined the specificity of observed effects by treatment with adrenomedullin (ADM) in stress conditions generated by 100 microM hydrogen peroxide. Using MTT assays, we demonstrate that a pretreatment with CGRP decreases by half the loss of cell viability induced by H(2)O(2). CGRP inhibits phosphatidylserine externalization, caspase 3 activation and DNA fr…

medicine.medical_specialtyCalcitonin Gene-Related PeptideCaspase 3DNA FragmentationCalcitonin gene-related peptideReceptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3Receptor Activity-Modifying ProteinsCell LineReceptor Activity-Modifying Protein 1Internal medicinemedicineAnimalsMyocytes CardiacViability assayMolecular BiologyReceptor activity-modifying proteinintegumentary systemChemistryCalcitonin Receptor-Like ProteinIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptors CalcitoninPeptide FragmentsRatsAdrenomedullinOxidative StressEndocrinologyGene Expression RegulationRAMP2ApoptosisRAMP1Multiprotein ComplexesIschemic Preconditioning MyocardialCardiology and Cardiovascular MedicineMioticsSignal TransductionJournal of molecular and cellular cardiology
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Effects of Leptin on Lipopolysaccharide-Induced Remodeling in an In Vitro Model of Human Myometrial Inflammation1

2013

Reorganization of myometrial extracellular matrix (ECM) is essential for the uterus to achieve powerful synchronous contractions during labor. Remodeling of the ECM has been implicated in membrane rupture and cervical ripening. Because maternal obesity is associated with both delivery disorders and elevated circulating leptin levels, this study aimed to assess the ability of leptin to interfere with lipopolysaccharide (LPS)-induced myometrial ECM remodeling. Myometrial biopsy samples were obtained from women undergoing cesarean delivery before labor onset. Myometrial explants were incubated for 48 h with LPS and leptin. LPS challenge was associated with a marked decrease in collagen content…

medicine.medical_specialtyMMP2LeptinMyometriumInflammationCell BiologyGeneral MedicineBiologyMatrix metalloproteinaseMMP9Extracellular matrixEndocrinologyReproductive MedicineInternal medicineHeat shock proteinmedicinemedicine.symptomBiology of Reproduction
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Mesoangioblast MMP2 regulation is dependent on Hsp70 level

2012

mesoangioblastMMP2Hsp70
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AGE6. Skin Ageing: Focus on the Role of Inflammatory Genetic Factors in Cutaneous Neoplasia

2014

AGE6. Skin Ageing: Focus on the Role of Inflammatory Genetic Factors in Cutaneous Neoplasia C. M. Gambino1, F. Crapanzano1, G. Accardi1, A. Aiello1, C. Virruso1, G. Pistone1, M. R. Bongiorno1, D. Lio1, C. R. Balistreri1, G. Candore1 1University of Palermo, Palermo, Italy Background: Skin aging is a complex process that involves intrinsic and exogenous causes. Photo-oxidative damage caused by UV is the leading cause of extrinsic aging of the skin, known as photo-ageing. UV damages can be linked mostly to overproduction of ROS that induces a complex molecular cascade able to accelerate physiological aging, determining a typical dermal/epidermal inflammation with an increased risk of getting s…

rs.4986790) TLR4 (+1196 C/T rs.4986791) MMP2 (-1306 C/T rs.243865) and MMP9 (-1562 C/T rs.3918242)SNPsSkin aging TLR4 (+896 A/G; rs.4986790) TLR4 (+1196 C/T rs.4986791) MMP2 (-1306 C/T rs.243865) and MMP9 (-1562 C/T rs.3918242)SNPsSkin aging TLR4 (+896 A/G
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Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm

2014

Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…

tPA ( rs2020918)ACE (rs1799752)]PAI-1 (rs1799768)TAFI (rs2146881)] inflammation [TLR4 (rs4986790)Factor V (rs6025)CCR5 (rs333)] extra-cellular matrix remodeling [MMP9 (rs3918242)vascular remodeling (VR) and medial degeneration (MD)sporadic thoracic aortic aneurysm (TAA)polymorphisms of the coagulation system [fibrinogen (rs1800790)MMP2 (rs243865)] endothelium dysfunction [eNOs (rs 1799983)Factor II ( rs1799963)Factor VII (rs121964926)
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