Search results for "MP3"
showing 5 items of 5 documents
Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates
2021
Ectodomain shedding is a key mechanism of several biological processes, including cell-communication. Disintegrin and metalloproteinases (ADAMs), together with the membrane-type matrix metalloproteinases, play a pivotal role in shedding transmembrane proteins. Aberrant shedding is associated to several pathological conditions, including arthritis. Tissue inhibitor of metalloproteases 3 (TIMP-3), an endogenous inhibitor of ADAMs and matrix metalloproteases (MMPs), has been proven to be beneficial in such diseases. Thus, strategies to increase TIMP-3 bioavailability in the tissue have been sought for development of therapeutics. Nevertheless, high levels of TIMP-3 may lead to mechanism-based …
Micro-RNA profile and proteins in peritoneal fluid from women with endometriosis: their relationship with sterility.
2018
Objective: To define the microRNA (miRNA) profile and its relationship with cytokines content in peritoneal fluid (PF) from endometriosis patients. Design: Case-control study. Setting: University hospital, research institute. Patient(s): One hundred twenty-six women with endometriosis (EPF) and 45 control women (CPF). Main Outcomes Measure(s): MiRNA arrays were prepared from six EPF and six CPF. Quantitative reverse transcription-polymerase chain reaction validation of nine selected miRNAs (miR-29c-3p, -106b-3p, -130a-3p, -150-5p, -185-5p, -195-5p, -451a, -486-5p, and -1343-5p) was performed. Vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1), urokinase plasminogen acti…
Fan's affect for music record formats : from vinyl LP to MP3
2014
Suosituimmat musiikkitallenneformaatit ovat muuttuneet analogisista vinyylilevyistä ja C-kaseteista digitaalisiin CD-levyihin ja äänitiedostoihin. Silti vinyylilevyt, erityisesti LP-levyt, ovat säilyneet markkinoilla. Levyjä julkaisseiden artistien live-konsertit ovat edelleen merkittävä musiikin kuluttamisen muoto. Tässä tutkielmassa tarkastellaan eri musiikkitallenneformaatteja pitäen live-konsertit vertailun pohjana, ja kartoitetaan formaatteja koskevia seikkoja, jotka ovat merkityksellisiä faneille. Tutkielman teoreettinen perusta on populaari- ja digitaalisen kulttuurin tutkimuksessa, sekä fanitutkimuksessa. Tutkielmassa viitataan mediateksteihin, ja tutkielmaa varten on haastateltu he…
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
2011
CNS myelination by oligodendrocytes requires directed transport of myelin membrane components and a timely and spatially controlled membrane expansion. In this study, we show the functional involvement of the R-solubleN-ethylmaleimide-sensitive factor attachment protein receptor (R-SNARE) proteins VAMP3/cellubrevin and VAMP7/TI-VAMP in myelin membrane trafficking. VAMP3 and VAMP7 colocalize with the major myelin proteolipid protein (PLP) in recycling endosomes and late endosomes/lysosomes, respectively. Interference with VAMP3 or VAMP7 function using small interfering RNA-mediated silencing and exogenous expression of dominant-negative proteins diminished transport of PLP to the oligodendro…