Search results for "MPAs"
showing 10 items of 226 documents
Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with…
2017
Summary Background We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decompensation while approval of these regimens was pending in Italy. Methods In this prospective observational study, we collected data from a compassionate use nationwide programme from March 17, 2014, to May 28, 2015. Patients with HCV genotype 1 infection and cirrhosis at high risk of decompensation were given coformulated ombitasvir (25 mg), …
In situ activity of a bacteriocin-producing Lactococcus lactis strain. Influence on the interactions between lactic acid bacteria during sourdough fe…
2005
Aims: To biochemically characterize the bacteriocin produced by Lactococcus lactis ssp. lactis M30 and demonstrate its effect on lactic acid bacteria (LAB) during sourdough propagation. Methods and Results: A two-peptide bacteriocin produced by L. lactis ssp. lactis M30 was purified by ion exchange, hydrophobic interaction and reversed phase chromatography. Mass spectrometry of the two peptides and sequence analysis of the ltnA2 gene showed that the bacteriocin was almost identical to lacticin 3147. During a 20-day period of sourdough propagation the stability of L. lactis M30 was demonstrated, with concomitant inhibition of the indicator strain Lactobacillus plantarum 20, as well as the …
A taxonomic survey of lactic acid bacteria isolated from wheat (Triticum durum) kernels and non-conventional flours
2007
In order to explore the correspondence between raw material- and mature sourdough-lactic acid bacterial (LAB) communities, 59 Italian wheat (Triticum durum) grain samples, one bran and six non-conventional flour samples were analyzed through a culture-dependent approach. The highest cell count by an agar medium specific for LAB was 2.16 log CFU/g. From about 2300 presumptive LAB (Gram-positive and catalase-negative) colonies collected, a total of 356 isolates were subjected to identification by a genetic polyphasic strategy consisting of RAPD-PCR analysis, partial 16S rRNA gene sequencing, species-specific and multiplex PCRs. The isolates were recognized as 137 strains belonging to Aerococc…
Rapid differentiation and in situ detection of 16 sourdough lactobacillus species by multiplex PCR.
2005
ABSTRACT A two-step multiplex PCR-based method was designed for the rapid detection of 16 species of lactobacilli known to be commonly present in sourdough. The first step of multiplex PCR was developed with a mixture of group-specific primers, while the second step included three multiplex PCR assays with a mixture of species-specific primers. Primers were derived from sequences that specify the 16S rRNA, the 16S-23S rRNA intergenic spacer region, and part of the 23S rRNA gene. The primer pairs designed were shown to exclusively amplify the targeted rrn operon fragment of the corresponding species. Due to the reliability of simultaneously identifying Lactobacillus plantarum , Lactobacillus…
Event-based encoding from digital magnetic compass and ultrasonic distance sensor for navigation in mobile systems
2016
Event-based encoding reduces the amount of generated data while keeping relevant information in the measured magnitude. While this encoding is mostly associated with spiking neuromorphic systems, it can be used in a broad spectrum of tasks. The extension of event-based data representation to other sensors would provide advantages related to bandwidth reduction, lower computing requirements, increased processing speed and data processing. This work describes two event-based encoding procedures (magnitude-event and rate-event) for two sensors widely used in industry, especially for navigation in mobile systems: digital magnetic compass and ultrasonic distance sensor. Encoded data meet Address…
La literatura emblemática, Goya y la avaricia
1991
GOYA, A CABALLO ENTRE DOS EPOCAS, RECURRIO A LA EMBLEMATICA COMO FUENTE DE INSPIRACION EN ALGUNAS DE SUS OBRAS, A LAS QUE IMPRIMIO SU PERSONAL INTERPRETACION. CON ESTA ORIENTACION, ENTRE SUS PRINCIPALES FUENTES SE ENCUENTRAN LOS EMBLEMAS DE ALCIATO Y EL TEATRO MORAL DE VAENIUS. (A.B.C./ L.A.G.)
Alla periferia del mondo, ai margini dell’umano. Felicità e dolore in Diodoro
2020
In the proem of his Bibliotheke, Diodorus Siculus states that a historian should provide knowledge for all mankind. Hence, the value of a historian is not measured by his ability to gather in a single narrative stories of men from all times all over the world. What matters is the way in which the common human nature of all of the actors in history emerges. This contribution focuses on the first part of Book III, in particular on the Ichthyophagoi and Acridophagoi, where the historian’s gaze oscillates between idealisation and compassion towards such primitive peoples. The diodorean ethnographic report has the merit to provide a backdrop to some of the guidelines of the cultural debate in th…
First Measurement of Transverse-Spin-Dependent Azimuthal Asymmetries in the Drell-Yan Process
2017
The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190 GeV/$c$, $\pi^{-}$ beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3 GeV/$c^2$ and 8.5 GeV/$c^2$. The observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of Quantum Chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic sc…
Sivers asymmetry extracted in SIDIS at the hard scales of the Drell-Yan process at COMPASS
2017
Proton transverse-spin azimuthal asymmetries are extracted from the COMPASS 2010 semi-inclusive hadron measurements in deep inelastic muon-nucleon scattering in those four regions of the photon virtuality $Q^2$, which correspond to the four regions of the di-muon mass $\sqrt{Q^2}$ used in the ongoing analysis of the COMPASS Drell-Yan measurements. This allows for a future direct comparison of the nucleon transverse-momentum-dependent parton distribution functions extracted from these two alternative measurements. Various two-dimensional kinematic dependences are presented for the azimuthal asymmetries induced by the Sivers transverse-momentum-dependent parton distribution function. The inte…
Avisos y relaciones manuscritos y impresos sobre catastrofes naturales y sucesos prodigiosos en Sicilia durante el siglo XVIII
2021
In the eighteenth century there is a large number of stories, both handwritten and in print, that describe extraordinary and unlucky events of different kinds: monstrosities, eclipses, or storms, floods, earthquakes, eruptions, etc. These stories, with respect to Sicily, take the form of occasional printed news, although sometimes they may be included in serials organized by different criteria (topographic/chronological/subject). Surviving documents in archives and libraries offer some opportunities to deepen the study of issues concerning the circulation and dissemination of news about the same event, their credibility, their formal characters and content. Very rare printed ephemera and ha…