Search results for "MPL"
showing 10 items of 21777 documents
Import and impact : characterization of parvovirus-nucleus interactions
2016
Mast cells as protectors of health.
2019
Mast cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T-cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focuses on the beneficial effects of MCs on tissue homeostasis and elimination of toxins or venoms. MCs can enhance pathogen clearance in many bacter…
Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
2021
The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating th…
Elektrostatiski vadāmu tuneļbarjeru modelēšana kvantu termoelektrisko efektu izpētei
2015
Mūsdienu nanoelektroniskas ierīces ļauj precīzi manipulēt atsevišķu elektronu stāvokļus, izmantojot elektrostatiski vadāmās tuneļbarjeras. Elektronam piemīt lādiņš un enerģija, tāpēc ir iespējams precīzi kontrolēt arī tunelēšanas strāvas un siltuma plūsmas. Darbā tiks pētīta enerģijas pārnese elektronu kvantu sūkņos, izmantojot elektrostatiski vadāmo tuneļbarjeru fenomenoloģiskus modeļus un kinētiskos vienādojumus. Sūkņa darbība notiks līdzsvara režīmā, ļaujot saistīt modeļa mikrostāvokļus ar ierīces temperatūru.
An experimental and theoretical study of a heptacoordinated tungsten(VI) complex of a noninnocent phenylenediamine bis(phenolate) ligand
2018
Abstract [W(N2O2)(HN2O2)] (H4N2O2 = N,N′-bis(3,5-di-tert-butyl-2-hydroxyphenyl)-1,2-phenylenediamine) with a noninnocent ligand was formed by reaction of the alkoxide precursor [W(eg)3] (eg = the 1,2-ethanediolate dianion) with two equivalents of ligand. The phenol groups on one of the ligands are completely deprotonated and the ligand coordinates in a tetradentate fashion, whereas the other ligand is tridentate with one phenol having an intact OH group. The molecular structure, magnetic measurements, EPR spectroscopy, and density functional theory calculations indicate that the complex is a stable radical with the odd electron situated on the tridentate amidophenoxide ligand. The formal ox…
On the mechanism of imine elimination from Fischer tungsten carbene complexes
2016
(Aminoferrocenyl)(ferrocenyl)carbene(pentacarbonyl)tungsten(0) (CO)5W=C(NHFc)Fc (W(CO)5(E-2)) is synthesized by nucleophilic substitution of the ethoxy group of (CO)5W=C(OEt)Fc (M(CO)5(1Et)) by ferrocenyl amide Fc-NH– (Fc = ferrocenyl). W(CO)5(E-2) thermally and photochemically eliminates bulky E-1,2-diferrocenylimine (E-3) via a formal 1,2-H shift from the N to the carbene C atom. Kinetic and mechanistic studies to the formation of imine E-3 are performed by NMR, IR and UV–vis spectroscopy and liquid injection field desorption ionization (LIFDI) mass spectrometry as well as by trapping experiments for low-coordinate tungsten complexes with triphenylphosphane. W(CO)5(E-2) decays thermally i…
User expectations, use experiences and continued adoption of a mobile secure communication application
2018
The importance of secure communication between employees in enterprises and governmental organizations as well as technologies to support that has increased tremendously over the past years. This study examines the user expectations before and the use experiences during the implementation phase of a mobile secure communication application together with expectation–confirmation and its influence on continued adoption. The study is explorative in nature and empirically based on thematic analysis of qualitative data collected from pilot users of a mobile secure communication application who work in a governmental organization in Finland. The theoretical basis of the study draws from two well-e…
La preservación del favor filii en supuestos de ruptura de la convivencia de los acogedores, tutores o guardadores del menor
2021
Cuando la guarda del menor por parte de los progenitores no es posible y esta es atribuida de forma conjunta a dos personas convivientes que posteriormente cesan dicha convivencia, resulta necesario determinar cuál de ellas va a ejercer a partir de ese momento las funciones inherentes a dicha guarda. Las posibles soluciones dependerán de si se trata de un supuesto de acogimiento, de tutela o de siempre guarda. When care of the child by the parents is not possible and is attributed jointly to two people living together who subsequently stop living together, it is necessary to determine which of them will exercise the functions inherent to the care from that moment on. The possible solutions …
Las Prácticas en Empresas en la Universidad: Diseño y Validación de un Modelo de Gestión de la Calidad
2015
Esta investigación se ha planteado como una necesidad de reflexionar y profundizar sobre las prácticas en empresas como metodología formativa destacada en la preparación del universitario, así como abordar el papel de los agentes implicados y las relaciones que se establecen entre ellos, haciendo especial atención a los tutores. Para ello, hemos realizado dos estudios correlativos que nos han permitido configurar nuestro Modelo de Gestión de la Calidad de las Prácticas en Empresas Universitarias, para que pueda ser aplicado en cualquier titulación, centro o Universidad. En el primer estudio, hemos concebido un Modelo de calidad de las prácticas en empresas, validado por un panel de expertos…
Video Recruitment : Online Perspectives and Implications for Employer Branding
2022
Video recruitment—the use of videos at any point in the recruitment process—has surged among organizations as a strategy for hiring talent and operating in their respective fields amid the pandemic. In particular, video interviews have become mainstream at the assessment stage of the recruitment funnel to keep hiring workers in a remote context of work. Among job video interviews, the asynchronous type especially raised interest and concerns online. This chapter offers a novel and essential approach to the study of video interviews through the theoretical exploration of the crossover between HRM, marketing, and information technology, with the goal of uncovering several ways that employer b…