Search results for "MPL"
showing 10 items of 21777 documents
Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes.
2002
<i>Objectives:</i> In an attempt to develop virus-like particles (VLPs) as experimental vaccine against human papilloma virus (HPV)-induced tumours, the HPV16 E7 oncoprotein epitopes spanning amino acid (aa) residues 35–98 were expressed on three proteins capable of VLP formation: hepatitis B virus (HBV) surface (HBs) and core (HBc) antigens, and RNA phage fr coats (frCP). <i>Methods:</i> The profile of immunoglobulin isotypes induced in Balb/C mice after immunization with purified chimeric proteins was studied. <i>Results:</i> The HBs*-E7(35–54) protein expressing E7 residues 35–54 between residues 139 and 142 of the HBs carrier formed HBs-like particles…
Quantitative microscopy reveals stepwise alteration of chromatin structure during herpesvirus infection
2019
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm. We have shown previously that HSV-1 infection induces the formation of channels through the compacted peripheral chromatin. Here, we used three-dimensional confocal and expansion microscopy, soft X-ray tomography, electron microscopy, and random walk simulations to analyze the kinetics of host chromatin redistribution and capsid localization relative to their egress site at the nuclear envelope. Our data demonstrated a gradual increase in chromatin marginalization, and the kinetics of chromatin smoothening arou…
Enhancement by TNF-alpha of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice.
1995
The influence of tumor-necrosis-factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) and IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-alpha and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivation frequency and replication of HSV. Interferon alpha/beta (IFN alpha/beta) prevented reactivation and replication.
Vispārējās anestēzijas ietekme uz acs akomodācijas funkcijām
2018
Maģistra darbs ir uzrakstīts latviešu valodā, datorsalikumā uz 39 lapām. Tas satur 13 attēlus, 8 tabulas, 4 pielikumus un 28 atsauces uz literatūras avotiem. Darba mērķis ir kvantitatīvi novērtēt vispārējās anestēzijas ietekmi uz acs akomodācijas funkcijām. Acs akomodācijas funkcijas tika novērtētas vispārējās un spinālās anestēzijas pacientiem pirms un pēc operācijas. Akomodācijas funkciju perioperatīvās relatīvās izmaiņas starp vispārējās anestēzijas un spinālās anestēzijas grupu nav statistiski nozīmīgi atšķirīgas, tomēr vispārējās anestēzijas grupā pacientiem novērojamas statistiski nozīmīgas akomodācijas amplitūdas perioperatīvās relatīvās izmaiņas. Akomodācijas amplitūdas perioperatīv…
Visual Methodologies and Geography's education in the pandemic time: notes on geopolitics of migration in the "Mediterranean Complex"
2022
<abstract> <p>The relationship between Geography and the Visual has always been strong intertwined. As it is true that Geography has always operates through images (in the form of pictures, creative representations and above all cartographies), in the last two years, with the distance learning due to the spread of the Covid-19 pandemic, this phenomenon has not only increased, but it also became necessary. "The classroom as the most radical space", in the words of bell hooks, had to turn into a virtual space, where images have a fundamental role in the teaching/learning process. This paper wants to analyse the relationship between Geography and the Visual by analysing three image…
Scleral Buckling: A Review of Clinical Aspects and Current Concepts
2021
Scleral buckling represents a valuable treatment option for rhegmatogenous retinal detachment repair. The surgery is based on two main principles: the closure of retinal breaks and the creation of a long-lasting chorioretinal adhesion. Buckles are placed onto the sclera with the purpose of sealing retinal breaks. Cryopexy is usually performed to ensure a long-lasting chorioretinal adhesion. Clinical outcomes of scleral buckling have been shown to be more favorable in phakic eyes with uncomplicated or medium complexity retinal detachment, yielding better anatomical and functional results compared with vitrectomy. Several complications have been described following scleral buckling surgery, s…
El trabajo cedido en el sistema de empleo español. Una aproximación sociológica desde las racionalidades y vivencias de los trabajadores cedidos
2020
Desde los años 80 han proliferado nuevas formas atípicas de empleo en el Estado Español. En este contexto, se legaliza el trabajo cedido en 1994. Según los últimos datos del Anuario de Estadísticas Laborales, el número de trabajadores cedidos es de 708.600 en 2017, habiendo alcanzado la cifra de 1.678.668 en 2009. En el ámbito académico español se ha examinado el trabajo cedido desde una perspectiva jurídica y económica. En menor medida encontramos algún estudio sobre la precariedad de las personas que tienen este estatus. No obstante, en el ámbito europeo encontramos varios estudios que analizan sus características, trayectorias laborales y condiciones de empleo. Glaymann(2005:20) plantea …
Ennakoivatko FOX osto- ja myyntioptioiden epäsymmetriset hinnat FOX-indeksin liikkeitä?
2002
Lidar detection of carbon dioxide in volcanic plumes
2015
Volcanic gases give information on magmatic processes. In particular, anomalous releases of carbon dioxide precede volcanic eruptions. Up to now, this gas has been measured in volcanic plumes with conventional measurements that imply the severe risks of local sampling and can last many hours. For these reasons and for the great advantages of laser sensing, the thorough development of volcanic lidar has been undertaken at the Diagnostics and Metrology Laboratory (UTAPRAD-DIM) of the Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA). In fact, lidar profiling allows one to scan remotely volcanic plumes in a fast and continuous way, and with high s…