Search results for "MPN"

showing 7 items of 7 documents

Platelets Contribution to Thrombin Generation in Philadelphia-Negative Myeloproliferative Neoplasms: The "Circulating Wound" Model.

2021

Current cytoreductive and antithrombotic strategies in MPNs are mostly based on cell counts and on patient’s demographic and clinical history. Despite the numerous studies conducted on platelet function and on the role of plasma factors, an accurate and reliable method to dynamically quantify the hypercoagulability states of these conditions is not yet part of clinical practice. Starting from our experience, and after having sifted through the literature, we propose an in-depth narrative report on the contribution of the clonal platelets of MPNs—rich in tissue factor (TF)—in promoting a perpetual procoagulant mechanism. The whole process results in an unbalanced generation of thrombin and i…

Blood PlateletsQH301-705.5platelet functionMPNInflammationReviewDiseaseBioinformaticsFibrinogenModels BiologicalCatalysisPAR receptorLeukemia Myeloid Chronic Atypical BCR-ABL NegativeInorganic ChemistryTissue factorThrombinAntithromboticmedicineAnimalsHumansThrombophiliaPlateletPhysical and Theoretical ChemistryBiology (General)Molecular BiologyQD1-999SpectroscopyPAR receptorsbusiness.industryOrganic ChemistryThrombinGeneral MedicineComputer Science ApplicationsChemistryReceptors FibrinogenCoagulationthrombin generationBiological Assayfibrinogenmedicine.symptombusinessmedicine.drugInternational journal of molecular sciences
researchProduct

Covid-19 in Philadelphia-negative myeloproliferative neoplasms: a GIMEMA survey on incidence, clinical management and vaccine

2022

VaccinesCancer ResearchMyeloproliferative DisordersOncologyCOVID19IncidenceNeoplasmsMPNsCOVID-19HumansPhiladelphia ChromosomeHematologyLeukemia
researchProduct

Méthode simple pour évaluer le potentiel endomycorhizogène d’un inoculum

2010

National audience; Les champignons mycorhizogènes à arbuscules (MA), forment une association mutualiste avec la plupart des plantes terrestres. Ils favorisent leur croissance et leur résistance à de nombreux stress biotiques et abiotiques. Leur utilisation en agriculture permet de limiter l’apport d’intrants chimiques. Pour gérer leur population il faut connaître leur abondance dans le sol, et donc évaluer le potentiel mycorhizogène du sol. Pour cela on utilise un test qui mesure le pouvoir de colonisation racinaire de ces symbiotes au niveau d’une plante piège. La méthode du « Most Probable Number » (MPN) est la plus utilisée. L’objectif de cette étude a été de comparer deux techniques d’é…

[SDV.SA]Life Sciences [q-bio]/Agricultural sciences[SDV.SA] Life Sciences [q-bio]/Agricultural sciencesChampignons endomycorhizogènesTest KhideuxMost Probable Number (MPN)
researchProduct

Students' school‐level symptoms mediate the relationship between a school's observed moisture problems and students’ subjective perceptions of indoor…

2020

Moisture damage can influence the subjective assessment of indoor air quality (subjective IAQ) in various ways. We studied whether the frequency of symptoms reported across students at school level mediates the relationship between observed mold and dampness in a school building and students' subjective IAQ. To answer this research question, we tested a multilevel path model. The analyzed data were created by merging two nationwide data sets: (a) survey data from students, including information on subjective IAQ (N = 24,786 students); (b) data from schools, including information on mold and dampness in a school building (N = 222). After the background variables were adjusted, schools' obser…

dampnessEnvironmental Engineering010504 meteorology & atmospheric sciencesKansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational healthschoolSubjective perceptioneducationAir MicrobiologyCHILDRENschools010501 environmental sciences01 natural sciencesSick building syndromeIndoor air qualitySurveys and QuestionnairesHumansEXPOSURESchool levelStudents0105 earth and related environmental sciencesENVIRONMENTAL-QUALITYSchools4. EducationMultilevel modelFungitechnology industry and agriculturePublic Health Environmental and Occupational HealthBuilding and ConstructionFRAMEWORK3142 Public health care science environmental and occupational healthSICK-BUILDING SYNDROMEADVANTAGESAir Pollution IndoorODORindoor environmental problemsMultilevel AnalysisASTHMAsymptomsmultilevel analysisPerceptionHEALTHMoisture DamagePsychologyindoor air qualityClinical psychologyIndoor Air
researchProduct

Students’ school‐level symptoms mediate the relationship between a school’s observed moisture problems and students’ subjective perceptions of indoor…

2021

Moisture damage can influence the subjective assessment of indoor air quality (subjective IAQ) in various ways. We studied whether the frequency of symptoms reported across students at school level mediates the relationship between observed mold and dampness in a school building and students’ subjective IAQ. To answer this research question, we tested a multilevel path model. The analyzed data was created by merging two nationwide data sets: 1) survey data from students, including information on subjective IAQ (N = 24,786 students); 2) data from schools, including information on mold and dampness in a school building (N = 222). After the background variables were adjusted, schools’ observed…

dampnesskoulutschoolsisäilmaeducationhomeoppilaatkosteusilmanlaatuindoor environmental problemssymptomsmultilevel analysisoireetindoor air qualitysairas rakennus -oireyhtymä
researchProduct

Dampness and student-reported social climate: two multilevel mediation models.

2021

Background Little previous research has analysed the relationship between schools' indoor air problems and schools' social climate. In this study, we analysed a) whether observed mould and dampness in a school building relates to students' perceptions of school climate (i.e. teacher-student relationships and class spirit) and b) whether reported subjective indoor air quality (IAQ) at the school level mediates this relationship. Methods The data analysed was created by merging two nationwide data sets: survey data from students, including information on subjective IAQ (N = 25,101 students), and data from schools, including information on mould and dampness in school buildings (N = 222). The …

mouldMaledampnessAdolescenteducationkosteusvauriotIndoor environmental problemsteacher-student relationshipsMultilevel analysislcsh:RC963-969HumansIndoor air qualityStudentsopettaja-oppilassuhdeMouldrakennuksetSchoolskoulutNegotiatingsisäilmalcsh:Public aspects of medicineResearchFungiClass spiritlcsh:RA1-1270Humidityhomeilmapiiri3142 Public health care science environmental and occupational healthTeacher-student relationshipsSocial ConditionskoulurakennuksetAir Pollution Indoor5141 Sociologyindoor environmental problemslcsh:Industrial medicine. Industrial hygieneclass spiritmultilevel analysisFemaleDampnessindoor air qualityEnvironmental health : a global access science source
researchProduct

The "gray zone" of the Ph-negative myeloproliferative neoplasm; proposal of a decision tree useful in the differential diagnosis

2010

ph-negative MPNbone marrow biopsySettore MED/08 - Anatomia Patologica
researchProduct