Search results for "MPP+"

Imaging biomarkers of behavioral impairments: A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model.

2018

Objective In patients with epilepsy, psychiatric comorbidities can significantly affect the disease course and quality of life. Detecting and recognizing these comorbidities is central in determining an optimal treatment plan. One promising tool in detecting biomarkers for psychiatric comorbidities in epilepsy is positron emission tomography (PET). Methods Results Behavioral and biochemical variables were cross-correlated with the results from two mu PET scans using the tracers [F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG) and 2 '-methoxyphenyl-(N-2 '-pyridinyl)-p-F-18-fluoro-benzamidoethylpiperazine ([F-18]MPPF) to explore potential biomarkers for neurobehavioral comorbidities in an electrica…

Imaging correlates of behavioral impairments: An experimental PET study in the rat pilocarpine epilepsy model

2018

Abstract Psychiatric comorbidities are prevalent in patients with epilepsy and greatly contribute to the overall burden of disease. The availability of reliable biomarkers to diagnose epilepsy-associated comorbidities would allow for effective treatment and improved disease management. Due to their non-invasive nature, molecular imaging techniques such as positron emission tomography (PET) are ideal tools to measure pathologic changes. In the current study we investigated the potential of [18F]fluoro-2-deoxy- d -glucose ([18F]FDG) and 2′-methoxyphenyl-(N-2′-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine ([18F]MPPF) as imaging correlates of neurobehavioral comorbidities in the pilocarpine …

Lähentymistä kylmän sodan sallimissa rajoissa : Unkarin ulkopoliittiset suhteet Suomeen 1960-luvulla rauhanomaisen rinnakkaiselon, puolueettomuuden j…

2008

Molecular characterization of congenital myasthenic syndromes in Spain.

2017

Congenital myasthenic syndromes (CMS) are a heterogeneous group of genetic disorders, all of which impair neuromuscular transmission. Epidemiological data and frequencies of gene mutations are scarce in the literature. Here we describe the molecular genetic and clinical findings of sixty-four genetically confirmed CMS patients from Spain. Thirty-six mutations in the CHRNE, RAPSN, COLQ, GFPT1, DOK7, CHRNG, GMPPB, CHAT, CHRNA1, and CHRNB1 genes were identified in our patients, with five of them not reported so far.. These data provide an overview on the relative frequencies of the different CMS subtypes in a large Spanish population. CHRNE mutations are the most common cause of CMS in Spain, …

Voices behind and beyond the label : the master narrative of ADHD (de)constructed by diagnosed children and their parents

2016

Artikkeliväitöskirja. Sisältää yhteenveto-osan ja neljä artikkelia. Article dissertation. Contains an introduction part and four articles. The dominant understanding of attention deficit hyperactivity disorder (ADHD) is that of diagnosed children “suffering” from neurodevelopmental condition owing to which they are prone to develop adverse life trajectories. This master narrative of ADHD and psychomedical and normative discourses it adheres to and employs have been integrated into the daily activities of homes and schools. This compilation dissertation study employs a social constructionist discourse framework and is located in the intersection of the disciplines of disability studies and s…

Transformative Teaching and Learning Through Engaged Practice : Lecturers’ and Students’ Experiences in a University and Underserved Community Partne…

2018

peer-reviewed The Community Wellness, Empowerment, Leadership and Lifeskills (CWell) program is a two-year community-driven program developed in partnership between an underserved-community in Limerick City, and staff at the University of Limerick (UL), Ireland. This paper explores the transformative teaching and learning experiences that arose throughout the duration of the progam for the lecturers and students. Data were collected through interviews and focus groups with lecturers and students involved in the program. Students supported the notion of “learning differently” and focused around prior learning and attitude to learning, learning about learning and impact of learning. Lecturers…

Identity tensions in dual career : the discursive construction of future selves by female Finnish judo athletes

2019

To date, few studies have explored how changes in the practices, policies, and politics of sport and education may be implicated in how young athletes think about and plan for the future. Drawing on cultural praxis and feminist poststructuralist frameworks, this paper explores whether and how dual career (DC) policies and practices in Finland guide female judo athletes’ imaginings about their future. Discourse analysis was used to analyse interviews with three adolescent (aged 16) and three young adult (aged 20, 23, and 27) elite female judo athletes. Differences were found in the ways the athletes in the different age groups constructed their future athletic, civic and gendered selves. We …

Kun hirviöiksi paljastumme : rikoskumppanuuden kokemus Dark Souls -pelissä

2018

Darbinieku pārvaldes sistēma

2021

Kvalifikācijas darba ietvaros ir izveidota programmatūra “Darbinieku pārvaldes sistēma”, kura daļēji atvieglos cilvēkresursu pārvaldību. Sistēma palīdzēs uzņēmumam pārvaldīt, kuri darbinieki būs noteiktajos projektos, to, cik stundas lietotājs ir nostrādājis projektos un atvieglos atvaļinājuma pieteikšanu. Programmatūrā var pārvaldīt darbinieku datus, piemēram, kā veidot projektus un tā amatus, kā arī pieteikties projektu amatiem. Sistēmā var pieteikt prombūtnes pie-teikumu, pievienot prasmes, kā arī pievienot dienas izdarītā ierakstus un apskatīt esošajā nedēļā izdarīto. Sistēmas ir kā tīmekļa lietotne un izveidei tika izmantota PHP programmēšanas valoda ar “Laravel” satvaru. Pirmkodā ir a…

Trust in the educational partnership narrated by parents of a child with challenging behaviour

2019

This study examined trust in educational partnership in the context of early childhood education and care (ECEC) in Finland, from the viewpoint of parents of a child with challenging behaviour. Typically, such children have difficulties in regulating their behaviour and emotions. Semi-structured interviews with 23 parents were content-analysed in a narrative framework. The analysis revealed two critical elements of trust in educational partnership: (1) Child well-being in the day care centre, and (2) a supportive parent–educator relationship and collaboration. Critical factors in the first element of trust were educators’ respectful and good-quality relationships with the child and fair and…