Search results for "MPS"

Dipolar Rings of Microscopic Ellipsoids: Magnetic Manipulation and Cell Entrapment

2016

We study the formation and dynamics of dipolar rings composed by microscopic ferromagnetic ellipsoids, which self-assemble in water by switching the direction of the applied field. We show how to manipulate these fragile structures and control their shape via application of external static and oscillating magnetic fields. We introduce a theoretical framework which describes the ring deformation under an applied field, allowing to understand the underlying physical mechanism. Our microscopic rings are finally used to capture, entrap and later release a biological cell via magnetic command, i.e. performing a simple operation which can be implemented in other microfluidic devices which make us…

Magnetic functionalities in MOFs: from the framework to the pore

2017

In this review, we show the different approaches so far developed to prepare Metal-Organic Frameworks (MOFs) presenting electronic functionalities, with particular attention to magnetic properties. We will cover the chemical design of the framework necessary for the incorporation of different magnetic phenomena, as well as the encapsulation of functional species in the pores leading to hybrid multifunctional MOFs combining an extended lattice with a molecular lattice.

Fibre Bragg gratings tuned and chirped using magnetic fields

1997

The authors report on the use of magnetic fields in conjunction with magnetostrictive materials for tuning and chirping optical fibre Bragg gratings. The Bragg wavelength shifts as a consequence of the strain induced in the fibre by a magnetostrictive rod when a magnetic field is applied. A tuning range of 1.1 nm has been achieved by a magnetic field of 103 mT and the grating has been chirped by applying non-uniform magnetic fields.

Tumor and its microenvironment: a synergistic interplay.

2013

The mutual and interdependent interaction between tumor and its microenvironment is a crucial topic in cancer research. Recently, it was reported that targeting stromal events could improve efficacies of current therapeutics and prevent metastatic spreading. Tumor microenvironment is a "complex network" of different cell types, soluble factors, signaling molecules and extracellular matrix components, which orchestrate the fate of tumor progression. As by definition, cancer stem cells (CSCs) are proposed to be the unique cell type able to maintain tumor mass and survive outside the primary tumor at metastatic sites. Being exposed to environmental stressors, including reactive oxygen species …

Ethanol-Mediated Stress Promotes Autophagic Survival and Aggressiveness of Colon Cancer Cells via Activation of Nrf2/HO-1 Pathway

2019

Epidemiological studies suggest that chronic alcohol consumption is a lifestyle risk factor strongly associated with colorectal cancer development and progression. The aim of the present study was to examine the effect of ethanol (EtOH) on survival and progression of three different colon cancer cell lines (HCT116, HT29, and Caco-2). Our data showed that EtOH induces oxidative and endoplasmic reticulum (ER) stress, as demonstrated by reactive oxygen species (ROS) and ER stress markers Grp78, ATF6, PERK and, CHOP increase. Moreover, EtOH triggers an autophagic response which is accompanied by the upregulation of beclin, LC3-II, ATG7, and p62 proteins. The addition of the antioxidant N-acetyl…

Hierarquia e autoridade capetíngia no século XI: imagem e texto

2011

Em um caderno de 6 fólios, um deles hoje desaparecido, de pequeno formato (170 x 250 mm), em torno de 1076-1077, os cônegos regulares da abadia de Saint-Martin-des-Champs compuseram uma obra, conservada atualmente na British Library (Add 11662, f. 4r-8r), que reúne em torno de três atos diplomáticos, uma narrativa em versos e em imagens. Conhecida como " chronique versifiée " ou " livre des privilèges ", e editado em 1912 por Jean Depoin, o manuscrito foi copiado com a adição de três outros documentos e uma nova interpretação das imagens em meados do século XIII, obra que se encontra hoje em Paris (BnF, nouv. acq. lat. 1359). Nenhum estudo analisou ainda atentadamente as imagens contidas no…

Antiguos puertos e islas en el litoral andaluz: cartografía, toponimia e historia

2003

Se trata de recordar y agradecer las enseñanzas del Dr. Rosselló y aplicarlas a las costas andaluzas, de cuyas variadas formas llaman la atención los procesos de aterramiento de la parte atlántica, donde hay lugares cuya situación actual no responde a su topónimo (Isla Cristina, San Juan del Puerto...). A estudios anteriores, añadimos noticias históricas y trazados de mapas, que señalan una rápida evolución, referido principalmente a tres ámbitos. La desembocadura del Guadiana, que pasa en época histórica de barras arenosas e islas a zonas cultivadas y urbanizaciones de playas; el antiguo estuario del río Piedras, con puertos aún en el XIX, que sustenta hoy marismas, naranjales y cultivos d…

Type B Aortic Dissection Diagnosed by Left-Sided Transthoracic Ultrasonography in a Woman With Preeclampsia

2017

AISF position paper on liver disease and pregnancy.

2016

Abstract The relationship between liver disease and pregnancy is of great clinical impact. Severe liver disease in pregnancy is rare; however, pregnancy-related liver disease is the most frequent cause of liver dysfunction during pregnancy and represents a severe threat to foetal and maternal survival. A rapid differential diagnosis between liver disease related or unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. This report summarizes the recommendation of an expert panel established by the Italian Association for the Study of the Liver (AISF) on the management of liver disease during pregnancy. The article provides an overview of liver disea…

Organelle pH studies using targeted avidin and fluorescein–biotin

2000

Abstract Background: Mammalian organelles of the secretory pathway are of differing pH. The pH values form a decreasing gradient: the endoplasmic reticulum (ER) is nearly neutral, the Golgi is mildly acidic and the secretory granules are more acidic still (∼pH 5). The mechanisms that regulate pH in these organelles are still unknown. Results: Using a novel method, we tested whether differences in H + ‘leak' and/or counterion conductances contributed to the pH difference between two secretory pathway organelles. A pH-sensitive, membrane-permeable fluorescein–biotin was targeted to endoplasmic-reticulum- and Golgi-localized avidin-chimera proteins in HeLa cells. In live, intact cells, ER pH (…