Search results for "MR-proADM"

showing 3 items of 3 documents

Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19

2021

Abstract Objective The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19. Methods We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated. Results Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3–2.95 vs median, 0.82 nmol/L; interquartile range, 0.57–1.03; …

Lung DiseasesMalemedicine.medical_specialtySciencemedicine.medical_treatmentMR-proADMClinical BiochemistryComorbidityLabmed/1010Severity of Illness IndexGastroenterologyAdrenomedullinInterquartile rangeInternal medicineSeverity of illnessmedicineHumansAspartate AminotransferasesProtein PrecursorsSurvival analysisAgedRetrospective StudiesMechanical ventilationReceiver operating characteristicbiologyInterleukin-6SARS-CoV-2business.industryPatient SelectionBiochemistry (medical)C-reactive proteinCOVID-19Alanine TransaminaseRetrospective cohort studyMiddle AgedPrognosisSurvival Analysisrespiratory diseaseC-Reactive ProteininflammationHypertensionbiology.proteinbiomarkerBiomarker (medicine)FemaleTriagebusinessBiomarkersAcademicSubjects/MED00690Laboratory Medicine
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Mid-regional pro-adrenomedullin predicts poor outcome in non-selected patients admitted to an intensive care unit.

2018

AbstractBackgroundMortality risk and outcome in critically ill patients can be predicted by scoring systems, such as APACHE and SAPS. The identification of prognostic biomarkers, simple to measure upon admission to an intensive care unit (ICU) is an open issue. The aim of this observational study was to assess the prognostic value of plasma mid-regional pro-adrenomedullin (MR-proADM) at ICU admission in non-selected patients in comparison to Acute Physiology and Chronic Health Evaluation II (APACHEII) and Simplified Acute Physiology Score II (SAPSII) scores.MethodsAPACHEII and SAPSII scores were calculated after 24 h from ICU admission. Plasma MR-proADM levels were measured by TRACE-Kryptor…

Male030213 general clinical medicinemedicine.medical_specialtyMultivariate analysisPrognosiMR-proADMClinical BiochemistrySAPSII030204 cardiovascular system & hematologylaw.invention03 medical and health sciencesAdrenomedullin0302 clinical medicinelawPredictive Value of TestsClinical endpointMedicineHumansMortalitySimplified Acute Physiology ScoreAgedAged 80 and overReceiver operating characteristicbusiness.industryBiochemistry (medical)Area under the curveGeneral MedicineOdds ratioMiddle AgedIntensive care unitConfidence intervalIntensive Care UnitsICUEmergency medicineMultivariate AnalysisFemaleAPACHEIIbusinessBiomarkersClinical chemistry and laboratory medicineReferences
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Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia

2020

Abstract Objective In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy. Methods We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2). Results PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were …

Malemedicine.medical_specialtymedicine.medical_treatmentpediatric.Clinical BiochemistryLipopolysaccharide ReceptorsNeutropeniaAdrenomedullinmr-proADMmalignancieNeoplasmsInternal medicineAntineoplastic Combined Chemotherapy ProtocolsHumansneutropeniaMedicineBlood cultureProtein PrecursorsFever of unknown originChildFebrile NeutropeniafeverChemotherapymedicine.diagnostic_testReceiver operating characteristicbusiness.industryPresepsinBiochemistry (medical)Age FactorsPrognosismedicine.diseasePeptide FragmentsAdrenomedullinROC CurveoncologicBacteremiaFemalebusinessBiomarkersFebrile neutropeniaLaboratory Medicine
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