Search results for "MR"
showing 10 items of 3001 documents
Phytochemical investigation and antitumor activity of coumarins from Sicilian accession of Ferulago nodosa (L.) Boiss. roots
2023
Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area being present in Crete, Greece, Albania, and probably in Macedonia. From the roots of this accession of species, not previously investigated, four coumarins, grandivittin, aegelinol benzoate, felamidin and aegelinol, and two terpenoids, (2E)-3-methyl-4-[(3-methyl-1-oxo-2-buten-1yl)oxy]-2-butenoic acid and pressafonin-A, were isolated and spectroscopically characterized. The last one was never detected in Ferulago species. The evaluation of the anti-tumor effects of F. nodosa coumarins on colon cancer HCT116 cells showed only a modest effect on reduction of tumor cell viability. For aegelinol, the red…
Piederīgo līdzestība aprūpē pirmreizēji stacionētiem pacientiem ar demenci
2019
Bakalaura darba tēma: Piederīgo līdzestība aprūpē pirmreizēji stacionētiem pacientiem ar demenci. Tēmas aktualitāte: Tautas skaitīšanas dati apliecina to, ka sabiedrība noveco, vecu cilvēku īpatsvars palielinās. Ir aprēķināts, ka ap 2030. gadu apmēram viena ceturtdaļa Latvijas iedzīvotāji būs vecumā virs 60 gadiem. Zemās dzimstības un ekonomiskās migrācijas dēļ gados veciem cilvēkiem dzīves kvalitātes saglabāšanas iespējas bieži vien vērtējamas kā ierobežotas. Sabiedrības novecošanās un ar to saistītie procesi ir un būs nopietna sabiedrības veselības problēma Latvijā. Cilvēkiem, kas slimo ar demenci, piederīgo līdzestība aprūpē, ir būtisks priekšnoteikums ilgākai veselības saglabāšanai. Dar…
Hydrophobic interactions between aroma compounds and beta-Lactoglobulin using a specific fluorescent probe and NMR
2008
International audience; Many aroma compounds are known to bind with proteins, and elucidating these bindind interactions is a key in a better knowledgment of flavour perception mechanisms (1). beta-Lactoglobulin (bLg), the major whey protein of milk, has been used as a model food protein in numerous studies. Previous work have shown different binding sites on bLg for aroma compounds as a function of their chemical class, and emphasized the importance of hydrophobic interactions (2). (...)
Solid state conformational behavior and interactions of a series of aromatic oligoamide foldamers
2016
The topic of this thesis is aromatic oligoamide foldamers. The literary review of the thesis discusses the general features of foldamers and their design and then focuses on the specific examples of aromatic oligoamide foldamers. The experimental part of the thesis discusses the design and preparation of a family of aromatic oligoamide foldamers that can adopt a helical conformation. The folding is directed by intramolecular hydrogen bonding and stabilized by intramolecular aromatic interactions. The focus of the thesis is the analysis of the solid state conformations of ten foldamer analogues. The analysis is based on forty different crystal structures which are determined using single cry…
La croyance dans le fumoir : “The Portrait of Mr. WH”, l’éthique de la croyance de William Kingdon Clifford et l’assentiment selon John Henry Newman
2023
Wilde’s story “The Portrait of Mr. W.H.” blurs literary genres, asserts the importance of the false and plays with reader expectations. It has generated a substantial exege- sis, perhaps lacking in interest in the multi-faceted debates on belief running through the 1870s-1880s. Wilde takes part in that debate through a text of uncertain status and complex editorial history, contrasting Newmanian assent with W.K. Clifford’s ethics of belief (1877), before asserting the supremacy of desire, thus ruining all assent and epistemically justified belief. To the demanding philosophical-religious theories of Clifford and Newman, Wilde responds with an ambiguous, subversive narrative, intended to com…
Expression of inflammation-related genes in human atherosclerotic plaques
2010
Aims: Atherosclerosis is an inflammator y disease which molecular mechanisms are not been completely investigated. Our aim is to perform a wide expression study of inflammation related genes in human atherosclerotic plaques. Methods: The Human Inflammation Array (Applied Biosystems) was used to perform the mRNA quantification of 92 inflammation-related genes in 12 atherosclerotic plaques, their respective adjacent regions (with a lower grade lesion) and 7 healthy ar teries. The principle of the array is the real-time PCR amplification with a TaqMan probe specific for each gene. Data analysis was performed with SDS 2.3 software with the comparative Ct method using the gene beta-2-microglobulin as h…
Atropizomēru sintēze un to fizikāli ķīmisko īpašību izpēte simetriski un nesimetriski aizvietotu 1,4-dihidropiridīnu rindā
2016
Modificētā Hanča sintēzē ieguva simetriski un nesimetriski aizvietotus 1,4-dihidropiridīnu atropizomērus ar 2-(benzoksi)naft-1-il)-, 2-(naft-2-ilmetoksi)naft-1-il)- un citām stēriski lielām grupām heterocikla 4-vietā. Iegūtajiem savienojumiem ir apgrūtināta C(4)-C(1’) saites rotācija, un tās enerģijas barjeras novērtēšanai izmantoja 1D un 2D KMR spektroskopiju, mainot šķīdinātājus un uzņemšanas temperatūru, kā arī rentgenstruktūranalīzi un šķidrumu hromatogrāfiju ar hirālu kolonnu. 1,4-Dihidropiridīniem noteikti arī elektroķīmiskās oksidēšanās potenciāli.
Neurosciences and attachment theory: A brief review
2017
The attachment theory was proposed and elaborated by John Bowlby. Over the last ten years the attachment theory has attracted considerable interest in the field of mental health as it emphasizes how relationships that are established in the earliest stages of development have an impact on man in an indefinable and lifelong manner.
Multicenter Consistency Assessment of Valvular Flow Quantification With Automated Valve Tracking in 4D Flow CMR
2021
OBJECTIVES This study determined: 1) the interobserver agreement; 2) valvular flow variation; and 3) which variables independently predicted the variation of valvular flow quantification from 4-dimensional (4D) flow cardiac magnetic resonance (CMR) with automated retrospective valve tracking at multiple sites. BACKGROUND Automated retrospective valve tracking in 4D flow CMR allows consistent assessment of valvular flow through all intracardiac valves. However, due to the variance of CMR scanners and protocols, it remains uncertain if the published consistency holds for other clinical centers. METHODS Seven sites each retrospectively or prospectively selected 20 subjects who underwent whole …
Effects of pyrolysis conditions on the thermal transformation of chicken manure into char
2012
Biochar is a fine-grained and highly porous carbonaceous substance, arising from the pyrolitic decomposition of natural or synthetic organic materials. It is lately applied to soils to favorably affect soil physico-chemical properties, such as water and nutrient retention and cation exchange capacity (CEC). The extent of the effect of biochar on crop productivity is very variable due to the different biophysical interactions and processes that occur when it is applied to soils. Char properties are greatly influenced by both natures of feedstock and process conditions. An accurate characterization of biochar is crucial to evaluate the possibility to amend soil with such material by avoiding …