Search results for "MRP"
showing 7 items of 7 documents
The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling
2018
The NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPCs) and is abundantly expressed by tumors such as melanoma and glioblastoma. Functions of NG2 include an influence on proliferation, migration and neuromodulation. Similar to other type-1 membrane proteins, NG2 undergoes proteolysis, generating a large ectodomain, a C-terminal fragment (CTF) and an intracellular domain (ICD) via sequential action of α- and γ-secretases which is enhanced by neuronal activity. Functional roles of NG2 have so far been shown for the full-length protein, the released ectodomain and CTF, but not for the ICD. In this study, we characterized the role of the NG2 ICD in OPC and Human Embryonic Ki…
Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters
2021
Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC transporters have been identified as key players in various human diseases, such as multidrug-resistant cancer and atherosclerosis, but also neurodegenerative diseases, such as Alzheimer���s disease (AD). Most prominent and well-studied are ABCB1, ABCC1, and ABCG2, not only due to their contribution to the multidrug resistance (MDR) phenotype in cancer, but also due to their contribution to AD. However, our understanding of other ABC transporters is limited…
An explanation of the MRP formula in Operations Management Lesson 8
2023
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València An explanation on how the MRP formula works Operations Management Lesson 8
Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to pre…
2014
Background Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated the expression of genes involved in gemcitabine uptake in a selected cohort of patients with PDAC, with well-defined clinical-pathological features. Methods mRNA levels of hENT1, CHOP, MRP1 and DCK were evaluated by means of qRT-PCR in matched pairs of tumor and adjacent normal tissue samples collected from PDAC patients treated with gemcitabine after surgical tumor resection. To detect possible interaction between gene expression levels and to identify subgroups of patients a…
Impact of Midregional N‐Terminal Pro–Atrial Natriuretic Peptide and Soluble Suppression of Tumorigenicity 2 Levels on Heart Rhythm in Patients Treate…
2021
Background We assessed the impact of preprocedural plasma levels of MRproANP (midregional N‐terminal pro–atrial natriuretic peptide) and sST2 (soluble suppression of tumorigenicity 2) on recurrence of atrial fibrillation (AF) at 1 year after catheter ablation of AF. Methods and Results This was a prospective, multicenter, observational study including patients undergoing catheter ablation of AF. MRproANP and sST2 were measured in a peripheral venous blood preprocedure, and MRproANP was assessed in the right and left atrial blood during ablation. The primary end point was recurrent AF between 3 and 12 months postablation, defined as a documented (>30 seconds) episode of AF, flutter, or a…
In situ Pesticide Detection in Food Processing by Microwave Transduction Combined with Molecularly Imprinted Polymers
2016
International audience; Since 2005, the microwave transduction coupled with a sensitive material is devoted to gas detection. In this work, we demonstrate the possibility to detect liquid pollutant (pesticide, fungicide) for food-processing industry. The principle is based on the interaction of the pollutant with a sensitive material within a microwave structure. The sensor is submitted to an electromagnetic excitation in wideband frequencies (GHz) and presents a quantitative response to liquid pollutant expositions at low concentration. The retained sensitive material is a molecularly imprinted polymer (MIP) specific to the pesticide targeted in a model wine. The coupling with this materia…
Saistība starp briofītu funkcionālajām grupām, substrātu īpašībām un mežau augu sabiedrībām Moricsalas dabas rezervātā
2013
Anotācija Darba mērķis ir noskaidrot substrāta parametru ietekmi uz briofītu sugu bagātību, sugu sastopamību un sugu sadalījumu pa funkcionālajām grupām (dzīves formu un dzīves stratēģiju) dažādās meža augu sabiedrībās, kā arī izpētīt sūnu sugu sastāva mainību Moricsalā pēdējo 100 gadu laikā. Par pētāmo teritoriju izvēlēts Moricsalas dabas rezervātā, kas ir senākā aizsargājamā dabas teritorija Latvijā un ilgstoši neskartās dabas dēļ īpaši piemērota sūnu ekoloģijas izpētei. Pašlaik bagātīgu sūnu sugu sastopamību uz pētītajiem substrātiem nodrošina koku sugas ar atšķirīgu mizas reakciju, dažāda garuma un apkārtmēra kritalas, heterogēns koku sugu sastāvs. Pēdējo 100 gadu laikā Moricsalas meža …