Search results for "MSC"
showing 10 items of 261 documents
Which changes are needed to render all genera of the German lora monophyletic?
2016
53 p., gráf.
Let’s make Pulvigera great again: re-circumscription of a misunderstood group of Orthotrichaceae that diversified in North America
2020
Abstract Orthotrichum lyellii was described in 1878 based on the crisped leaves with plane margins on its elongated and branched stems, and on the presence of brood-bodies. In Europe, these characters remain constant, but in North America several similar forms lacking propagules have been described either at the specific or infraspecific level. These were all reduced to synonyms of O. lyellii. In 2015, Orthotrichum was divided, and O. lyellii was transferred to Pulvigera, a genus thus far considered to be monospecific. In this study, the variability of P. lyellii is analysed in an integrative taxonomic framework. Morphological studies on > 200 specimens, including the nomenclatural t…
Macrophage type modulates osteogenic differentiation of adipose tissue MSCs
2017
Since the reconstruction of large bone defects remains a challenge, knowledge about the biology of bone healing is desirable to develop novel strategies for improving the treatment of bone defects. In osteoimmunology, macrophages are the central component in the early stage of physiological response after bone injury and bone remodeling in the late stage. During this process, a switch of macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2) is observed. An appealing option for bone regeneration would be to exploit this regulatory role for the benefit of osteogenic differentiation of osteoprogenitor cells (e.g., mesenchymal stem cells; MSCs) and to eventually utilize this…
Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold
2020
Background In periodontal patients with jawbone resorption, the autologous bone graft is considered a "gold standard" procedure for the placing of dental prosthesis; however, this procedure is a costly intervention and poses the risk of clinical complications. Thanks to the use of adult mesenchymal stem cells, smart biomaterials, and active biomolecules, regenerative medicine and bone tissue engineering represent a valid alternative to the traditional procedures. Aims In the past, mesenchymal stem cells isolated from periodontally compromised gingiva were considered a biological waste and discarded during surgical procedures. This study aims to test the osteoconductive activity of FISIOGRAF…
The Immunomodulatory Properties of the Human Amnion-Derived Mesenchymal Stromal/Stem Cells Are Induced by INF-γ Produced by Activated Lymphomonocytes…
2020
Human mesenchymal stromal/stem cells (MSCs), being immunoprivileged and having immunomodulatory ability, represent a promising tool to be applied in the field of regenerative medicine. Based on numerous in vitro evidences, the immunological effects of MSCs on immune cells could depend on different mechanisms as cell-to-cell contact and paracrine signals. Furthermore, recent studies have shown that the immunomodulatory activity of MSCs is initiated by activated immune cells; thus, their interaction represents a potential homeostatic mechanism by which MSCs regulate the immune response. MSCs also release exosomes able to give different effects, in a paracrine manner, by influencing inflammato…
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery
2020
Spinocerebellar ataxia type-1 (SCA1) is caused by an abnormally expanded polyglutamine (polyQ) tract in ataxin-1. These expansions are responsible for protein misfolding and self-assembly into intranuclear inclusion bodies (IIBs) that are somehow linked to neuronal death. However, owing to lack of a suitable cellular model, the downstream consequences of IIB formation are yet to be resolved. Here, we describe a nuclear protein aggregation model of pathogenic human ataxin-1 and characterize IIB effects. Using an inducible Sleeping Beauty transposon system, we overexpressed the ATXN1(Q82) gene in human mesenchymal stem cells that are resistant to the early cytotoxic effects caused by the expr…
Moduli spaces of rank two aCM bundles on the Segre product of three projective lines
2016
Let P^n be the projective space of dimension n on an algebraically closed field of characteristic 0 and F be the image of the Segre embedding of P^1xP^1xP^1 inside P^7. In the present paper we deal with the moduli spaces of locally free sheaves E on F of rank 2 with h^i(F,E(t))=0 for i=1,2 and each integer t.
Hilbert space operators with two-isometric dilations
2021
A bounded linear Hilbert space operator $S$ is said to be a $2$-isometry if the operator $S$ and its adjoint $S^*$ satisfy the relation $S^{*2}S^{2} - 2 S^{*}S + I = 0$. In this paper, we study Hilbert space operators having liftings or dilations to $2$-isometries. The adjoint of an operator which admits such liftings is characterized as the restriction of a backward shift on a Hilbert space of vector-valued analytic functions. These results are applied to concave operators (i.e., operators $S$ such that $S^{*2}S^{2} - 2 S^{*}S + I \le 0$) and to operators similar to contractions or isometries. Two types of liftings to $2$-isometries, as well as the extensions induced by them, are construct…
Controlled polyhedral sweeping processes: existence, stability, and optimality conditions
2021
This paper is mainly devoted to the study of controlled sweeping processes with polyhedral moving sets in Hilbert spaces. Based on a detailed analysis of truncated Hausdorff distances between moving polyhedra, we derive new existence and uniqueness theorems for sweeping trajectories corresponding to various classes of control functions acting in moving sets. Then we establish quantitative stability results, which provide efficient estimates on the sweeping trajectory dependence on controls and initial values. Our final topic, accomplished in finite-dimensional state spaces, is deriving new necessary optimality and suboptimality conditions for sweeping control systems with endpoint constrain…
Existence de points fixes enlacés à une orbite périodique d'un homéomorphisme du plan
1992
Let f be an orientation-preserving homeomorphism of the plane such that f-Id is contracting. Under these hypotheses, we establish the existence, for every periodic orbit, of a fixed point which has nonzero linking number with this periodic orbit.