Search results for "MST"

Elektroniskā uzraudzība Latvijā un ASV

2016

Latvijā, nosacītas pirmstermiņa atbrīvošanas no soda ietvaros, ir ieviesta elektroniskā uzraudzība. Tādēļ svarīgi pētīt, vai pašreizējais normatīvo aktu regulējums ļauj elektroniskai uzraudzībai savus mērķus izpildīt efektīvi. Bakalaura darba autors šajā darbā pētīja elektroniskās uzraudzības institūta izcelsmi, pašreizējo piemērojumu un iespējamo paplašināšanos Latvijā, balstoties uz Amerikas Savienoto Valstu pieredzi.

Elektronenmikroskopische Untersuchungen zur Capillarhyper�mie in der stimulierten Goldhamsterschilddr�se

1966

Untersuchungen an 32 kalte- bzw. thyreotropinaktivierten Goldhamsterschilddrusen unter Vergleich mit den Glanduale thyreoideae 8 normaktiver Tiere ergaben: 1. Mit einsetzender Kolloidmobilisation werden oberhalb der lichtoptisch erkennbaren Basalmembran der Follikel gelegene, intraepitheliale Capillaren entfaltet. 2. Am Endothel dieser intraepithelialen Capillaren treten hierbei breitere Poren auf, die jedoch durch ein Diaphragma verschlossen bleiben (Endothelfenster). Anscheinend erfolgt ferner ein cytopemptischer Transport von Material aus dem erweiterten periendothelialen Spalt in Richtung Saftestrom. 3. In der Nachbarschaft aktivierter Thyreocyten, insbesondere wenn letztere Anzeichen e…

Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies

2016

A cell-based bioassay for the measurement of thyroid blocking autoantibodies (TBAb) has been recently reported. The analytical performance and validation of this bioassay is assessed and described.Chinese hamster ovary cells expressing a chimeric thyrotropin receptor were treated with bovine (b) TSH and different concentrations of an immunoglobulin G (IgG) monoclonal human TBAb (K1-70). TBAb was measured as a function of luciferase activity relative to bTSH alone and expressed as percent inhibition. Results obtained in the chimeric cell line were compared with those of a wild-type cell line. Analytical performance studies were subsequently performed with the chimeric cell line only.Immunode…

Effect of Hamstring Tightness and Fatigue on Dynamic Stability and Agility in Physically Active Young Men

2023

Hamstring extensibility has been defined as a factor to diminished dynamic stability and therefore increased risk of injury. The purpose of this study was to analyse the effects of hamstring tightness and fatigue on dynamic stability and agility. Nineteen participants were divided between the normal extensibility group (NEG) (n = 9, 82.2° ± 12.4°) and hamstrings tightness group (HTG) (n = 10, 64° ± 4.9°) using the passive straight leg raise test. To analyse dynamic stability and agility, they performed the modified Star Excursion Balance Test (mSEBT) and Dynamic Postural Stability Index (DPSI), and hexagon agility test, respectively, before and after a fatigue …

Variable X-ray emission from the accretion shock in the classical T Tauri star V2129 Ophiuchi

2011

The soft X-ray emission from high density plasma in CTTS is associated with the accretion process. It is still unclear whether this high density cool plasma is heated in the accretion shock, or if it is coronal plasma fed/modified by the accretion process. We conducted a coordinated quasi-simultaneous optical and X-ray observing campaign of the CTTS V2129 Oph (Chandra/HETGS data to constrain the X-ray emitting plasma components, and optical observations to constrain the characteristics of accretion and magnetic field). We analyze a 200 ks Chandra/HETGS observation of V2129 Oph, subdivided into two 100 ks segments, corresponding to two different phases within one stellar rotation. The X-ray …

Technological and molecular diversity of Lactobacillus plantarum strains isolated from naturally fermented sourdoughs.

2004

Thirty Lactobacillus (L.) plantarum strains, isolated from sourdough, were identified by biochemical tests as well as 16S rDNA sequencing and differentiated on the basis of technological properties, such as amylase, protease, phytase and antirope activities. These properties were shown to be widely differing among the strains, indicating a significant technological diversity. Genetic differentiation was achieved by restriction endonuclease analysis-pulsed field gel electrophoresis (REA-PFGE) that allowed the L. plantarum strains to be divided into 10 different genomic groups. Moreover, 32 different starters were employed in dough making experiments; each starter consisted of a single strain…

La implosión

1997

Comparison of a Novel Homogeneous Cyclic Amp Assay and a Luciferase Assay for Measuring Stimulating Thyrotropin-Receptor Autoantibodies.

2019

Objective: Stimulating thyrotropin-receptor antibodies (TSAb) cause Graves’ disease (GD). We tested a novel homogeneous fluorescent 3′,5′ cyclic adenine monophosphate (cAMP) assay for the detection of TSAb in a bioassay. Methods: Chinese hamster ovary (CHO) cell lines expressing either a chimeric (MC4) or wild-type (WT) TSH-R were incubated with the adenyl cyclase activator forskolin, a human TSAb monoclonal antibody (M22), and with sera from GD patients. Intracellular cAMP levels were measured using a Bridge-It® cAMP assay, and the results were compared with a luciferase-based bioassay. Results: Both cell lines were stimulated with forskolin concentrations (0.006–200 µM) in a dose-dependen…

Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thym…

2000

We studied the genotoxic and apoptosis-inducing properties of ganciclovir (GCV) and penciclovir (PCV) using Chinese hamster ovary cells stably transfected with the thymidine kinase (tk) gene of herpes simplex virus-1 (HSV-1). Cells expressing HSVtk were 300 and 100 times more sensitive than their isogenic HSVtk- counterparts to the cytotoxic effects of GCV and PCV, respectively. Using radiolabeled drugs, GCV was found to be incorporated into the genomic DNA much more effectively than PCV. GCV was highly potent in inducing chromosomal aberrations compared with PCV, which provoked less sister chromatid exchanges and chromosomal changes using equimolar or equitoxic doses. For both agents, apop…

DNA Modification Induced After Metabolic Activation of the Potent Carcinogen Dibenzo[a, l]pyrene in V79 Chinese Hamster Cells Stably Expressing Singl…

2000

Abstract The polycyclic aromatic hydrocarbon (PAH) dibenzo[a, l]pyrene (DB[a, l]P) has been found to be an environmental pollutant and, considering the available data from rodent bioassays, it represents the most carcinogenic member compound of the class of PAH yet discovered. To sort out the contribution of individual cytochromes P450 (P450) in the metabolic activation of this PAH, V79 cells stably expressing a single P450 isoform were treated with DB[a, l]P or enantiomeric DB[a, l]P-11,12-dihydrodiols (diols). Subsequent analysis of the DNA adducts formed revealed substantial differences in the adduct pattern and the total DNA binding depending on the cell line used. Human P450 1B1 effect…