Search results for "MT"

showing 10 items of 2759 documents

Influence of hydrogen on paramagnetic defects induced by UV laser exposure in natural silica

2005

Diffusion limited reactions of point defects were investigated in amorphous SiO2 exposed to UV laser light. Electron spin resonance and in situ absorption measurements at room temperature evidenced the annealing of E' centers and the growth of H(II) centers both occurring in the post-irradiation stage and lasting a few hours. These transients are caused by reactions involving molecular hydrogen H2, made available by dimerization of radiolytic H0.

In situCondensed Matter - Materials ScienceMaterials scienceHydrogenAnnealing (metallurgy)Materials Science (cond-mat.mtrl-sci)FOS: Physical scienceschemistry.chemical_elementPhotochemistryCrystallographic defectlaw.inventionAmorphous solidParamagnetismUV laserchemistrylawRadiolysisnatural silicaElectron paramagnetic resonanceHydrogen
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In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X
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"Table 46" of "Measurements of $W^\pm Z$ production cross sections in $pp$ collisions at $\sqrt{s} = 8$ TeV with the ATLAS detector and limits on ano…

2016

Ratio of $W^{+}Z$ over $W^{-}Z$ differential fiducial cross sections measured in all $\ell'^\pm \nu \ell^+ \ell'^-$ channels combined, where $\ell, \ell' = e, \mu$. The last bin is a cross section for all events above the lower end of the bin.

Inclusive8000.0Proton-Proton ScatteringZ ProductionRATIO OF DSIG/DMTWZP P --> (W+ + W-) Z0 X
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"Table 19" of "Measurements of $W^\pm Z$ production cross sections in $pp$ collisions at $\sqrt{s} = 8$ TeV with the ATLAS detector and limits on ano…

2016

Measured fiducial cross section in all $\ell'^\pm \nu \ell^+ \ell'^-$ channels combined, where $\ell, \ell' = e, \mu$. The first systematic uncertainty is the combined systematic uncertainty excluding theory and luminosity uncertainties, the second is the luminosity uncertainty. The last bin is a cross section for all events above the lower end of the bin.

InclusiveDSIG/DMTWZ8000.0Proton-Proton ScatteringZ ProductionDifferential Cross SectionAstrophysics::Cosmology and Extragalactic AstrophysicsW ProductionP P --> W+ Z0 X
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"Table 34" of "Measurements of $W^\pm Z$ production cross sections in $pp$ collisions at $\sqrt{s} = 8$ TeV with the ATLAS detector and limits on ano…

2016

Measured normalised fiducial cross section in all $\ell'^\pm \nu \ell^+ \ell'^-$ channels combined, where $\ell, \ell' = e, \mu$. The first systematic uncertainty is the combined systematic uncertainty excluding theory and luminosity uncertainties, the second is the luminosity uncertainty. The last bin is a cross section for all events above the lower end of the bin.

InclusiveDSIG/DMTWZ8000.0Proton-Proton ScatteringZ ProductionDifferential Cross SectionP P --> (W+ + W-) Z0 XAstrophysics::Cosmology and Extragalactic Astrophysics
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"Table 18" of "Measurements of $W^\pm Z$ production cross sections in $pp$ collisions at $\sqrt{s} = 8$ TeV with the ATLAS detector and limits on ano…

2016

Measured fiducial cross section in all $\ell'^\pm \nu \ell^+ \ell'^-$ channels combined, where $\ell, \ell' = e, \mu$. The first systematic uncertainty is the combined systematic uncertainty excluding theory and luminosity uncertainties, the second is the luminosity uncertainty. The last bin is a cross section for all events above the lower end of the bin.

InclusiveDSIG/DMTWZ8000.0Proton-Proton ScatteringZ ProductionDifferential Cross SectionP P --> (W+ + W-) Z0 XAstrophysics::Cosmology and Extragalactic Astrophysics
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"Table 20" of "Measurements of $W^\pm Z$ production cross sections in $pp$ collisions at $\sqrt{s} = 8$ TeV with the ATLAS detector and limits on ano…

2016

Measured fiducial cross section in all $\ell'^\pm \nu \ell^+ \ell'^-$ channels combined, where $\ell, \ell' = e, \mu$. The first systematic uncertainty is the combined systematic uncertainty excluding theory and luminosity uncertainties, the second is the luminosity uncertainty. The last bin is a cross section for all events above the lower end of the bin.

InclusiveDSIG/DMTWZ8000.0Proton-Proton ScatteringZ ProductionDifferential Cross SectionP P --> W- Z0 XAstrophysics::Cosmology and Extragalactic AstrophysicsW Production
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"Table 4" of "Searches for supersymmetry with the ATLAS detector using final states with two leptons and missing transverse momentum in sqrt{s} = 7 T…

2011

The tranverse mass distribution for same-sign dilepton events.

InclusiveP P --> LEPTON+ LEPTON+ JETS XProton-Proton ScatteringP P --> LEPTON- LEPTON- JETS XSUSY7000.0SupersymmetrySingle Differential DistributionJet ProductionDN/DMT
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XPO1 (Exportin-1) Is a Major Regulator of Human Erythroid Differentiation. Potential Clinical Applications to Decrease Ineffective Erythropoiesis of …

2015

Abstract Background We and others have shown that normal human erythroid cell maturation requires a transient activation of caspase-3 at late stages of maturation (Zermati et al, J Exp Med 2001). We further documented that, in human erythroblasts, the chaperone HSP70 is constitutively expressed and, at late stages of maturation, translocates into the nucleus and protects GATA-1, the master transcriptional factor critical for erythropoiesis, from caspase-3 cleavage (Ribeil et al, Nature 2007). During the maturation of human β-TM erythroblasts, HSP70 is sequestrated by excess of α-globin chains in the cytoplasm and as a consequence, GATA-1 is no longer protected from caspase-3 cleavage result…

Ineffective erythropoiesisImmunologyGATA1Stem cell factorCell BiologyHematologyBiologymedicine.disease_causeBiochemistryMolecular biologyCell nucleusmedicine.anatomical_structuremedicineErythropoiesisNuclear export signalNuclear localization sequencePI3K/AKT/mTOR pathwayBlood
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Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review

2019

Background Vaccine adjuvants are compounds that significantly enhance/prolong the immune response to a co-administered antigen. The limitations of the use of aluminium salts that are unable to elicite cell responses against intracellular pathogens such as those causing malaria, tuberculosis, or AIDS, have driven the development of new alternative adjuvants such as QS-21, a triterpene saponin purified from Quillaja saponaria. Purpose The aim of this review is to attempt to clarify the mechanism of action of QS-21 through either receptors or signaling pathways in vitro and in vivo with special emphasis on the co-administration with other immunostimulants in new adjuvant formulations, called a…

InflammasomesT-Lymphocytesmedicine.medical_treatmentHerpes zosterPharmaceutical ScienceMonophosphoryl Lipid AAPCs antigen presenting cellsMiceCMI cell mediated immunity0302 clinical medicineDrug DiscoveryHerpes Zoster VaccineMedicineNSCLC non small cell lung carcinomaCancerImmunity CellularVaccines Synthetic0303 health sciencesImmunogenicityIl-2 interleukine 2HIV human immunodeficiency virusLipid A030220 oncology & carcinogenesisCytokinesMolecular MedicineDCs dendritic cellsNK natural killerAdjuvantTLR Toll-like receptorHerpes Zoster VaccineCD cluster of differentiationAntigen-Presenting CellsCTL cytotoxic T lymphocytesHZ herpes zosterMPL 3-deacylated monophosphoryl lipidVaccine adjuvantImmunoadjuvantArticleVZV varicella zoster virus03 medical and health sciencesImmune systemAdjuvants ImmunologicAntigenPAMPs pathogen-associated molecular patternsMalaria VaccinesPRRs pathogen recognition receptorsQS-21 Quillaja saponaria Molina-fraction 21AnimalsMHC major histocompatibility complexMtb Mycobacterium tuberculosis bacteriaSARS severe acute respiratory syndromeAntigen-presenting cellIFN-γ interferon-gamma030304 developmental biologyPharmacologybusiness.industryA-β amyloid-betaTNF-α tumor necrosis factor-alphaSaponinsQS-21MalariaQuillaja saponariaComplementary and alternative medicineTCR T-cell receptorLiposomesImmunologyKLH keyhole limpet hemocyaninbusinessdLN draining lymph nodesMAPK mitogen activated protein kinasePhytomedicine
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