Search results for "MTBC"
showing 2 items of 2 documents
Similarity-Based Virtual Screening to Find Antituberculosis Agents Based on Novel Scaffolds: Design, Syntheses and Pharmacological Assays
2022
A method to identify molecular scaffolds potentially active against the Mycobacterium tuberculosis complex (MTBC) is developed. A set of structurally heterogeneous agents against MTBC was used to obtain a mathematical model based on topological descriptors. This model was statistically validated through a Leave-n-Out test. It successfully discriminated between active or inactive compounds over 86% in database sets. It was also useful to select new potential antituberculosis compounds in external databases. The selection of new substituted pyrimidines, pyrimidones and triazolo[1,5-a]pyrimidines was particularly interesting because these structures could provide new scaffolds in this field. T…
BLAST Database with all accesible non-tuberculous mycobacteria genomic sequences (Oct, 2018)
2019
In our work "Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics" (https://doi.org/10.1101/569384 ). We look for M. tuberculosis genes that are not present in organisms other tan MTBC. This database corresponds with the described database of 4,277 NTM assemblies.