Search results for "MTHFR"
showing 3 items of 13 documents
Genetic variants in the MTHFR are not associated with fatty liver disease.
2020
The common missense sequence variants of methylenetetrahydrofolate reductase (MTHFR), rs1801131 (c.A1298C) and rs1801133 (c.C677T), favour the development of hyperhomocysteinemia and diminished DNA methylation. Previous studies, carried out in small series and with suboptimal characterization of the hepatic phenotype, tested the association of these genetic variants with fatty liver disease (FLD), with conflicting results. Here, we assessed the association of rs1801131 and rs1801133 with hepatic phenotype in the Liver Biopsy Cross-Sectional Cohort, a large cohort (n=1375 from Italy and 411 from Finland) of European individuals with suspect FLD associated with dysmetabolism. A total of 1786 …
Therapeutical approach to plasma homocysteine and cardiovascular risk reduction
2008
Marcello Ciaccio, Giulia Bivona, Chiara BelliaDepartment of Medical Biotechnologies and Forensic Medicine, Faculty of Medicine, University of Palermo, ItalyAbstract: Homocysteine is a sulfur-containing aminoacid produced during metabolism of methionine. Since 1969 the relationship between altered homocysteine metabolism and both coronary and peripheral atherotrombosis is known; in recent years experimental evidences have shown that elevated plasma levels of homocysteine are associated with an increased risk of atherosclerosis and cardiovascular ischemic events. Several mechanisms by which elevated homocysteine impairs vascular function have been proposed, including impairment of endothelial…
Análisis del la relación del genotipado y marcadores de estrés oxidativo con la presencia y grado de vasculopatía periférica en pacientes con diabete…
2014
RESUMEN: Padecer diabetes tipo 2 (DM2) ejerce un efecto independiente y multiplicador en la incidencia de complicaciones vasculares, añadido a la presencia de factores de riesgo clásicos. No todos los diabéticos desarrollan con la misma gravedad la vasculopatía periférica (VP). Este riesgo está presente en la fase de prediabetes, donde las complicaciones vasculares pueden preceder a la aparición de la propia diabetes. La biología vascular ha puesto de manifiesto la participación de otros factores como el estrés oxidativo (EO) y el estado crónico inflamatorio en el incremento de este riesgo. Los principales sistemas conocidos de EO a nivel endotelial generan especies reactivas de oxígeno. Pa…