Search results for "MUC4"

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MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps

2017

Background Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, interacting with glucocorticoid receptor (GR) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Mucin 4 (MUC4)–tethered mucin is expressed in nasal polyp (NP) epithelial cells and upregulated under inflammatory conditions. Moreover, MUC4β has the capacity to interact with other intracellular proteins. We hypothesized that MUC4 modulates corticosteroid efficacy of patients with CRSwNP. Objective We sought to analyze the role of MUC4 in corticosteroid effectiveness in different cohorts of patients with CRSwNP and elucidate the possible mechanisms involved. Methods Eighty…

AdultMale0301 basic medicineSmall interfering RNAmedicine.drug_classImmunologyAnti-Inflammatory AgentsDrug ResistanceBiologyDexamethasoneCell LineYoung Adult03 medical and health sciencesNasal PolypsGlucocorticoid receptorPregnenedionesmedicineglucocorticoid receptorHumansImmunology and AllergyNasal polypsSinusitisCells CulturedDexamethasoneAgedRhinitisnasal polypGene knockdownMucin-4chronic rhinosinusitisMucincorticosteroid resistanceEpithelial CellsMiddle Agedmedicine.diseaseHEK293 Cells030104 developmental biologyMUC4Chronic DiseaseImmunologyCorticosteroidImmunohistochemistryFemalesense organsmedicine.drug

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