Search results for "MUCOSA"

Intestinal filtration as a consequence of increased mucosal hydraulic permeability

1980

Two mechanisms have been proposed to explain the secretory action of laxative compounds in the intestine: 1. increase of the intracellular amount of cyclic adenosine monophosphate due to stimulation of the adenylate cyclase system and 2. inhibition of intestinal transfer processes, in particular the Na,K-ATPase activated sodium absorption. In a set of in vivo and in vitro experiments in rat colon it could be demonstrated that dihydroxy bile acids (deoxycholate) and diphenolic laxatives (oxyphenisatin) enhance the hydraulic permeability of the mucosal tissue. The permeability changes take place--and there is good experimental evidence--at the zonulae occludentes which bind the epithelial cel…

Mesalazine for the treatment of inflammatory bowel disease

2013

Ulcerative colitis (UC) and Crohn's disease (CD) represent a chronic inflammatory condition of the bowel that often require lifelong medical therapy for the induction and maintenance of the remission. Mesalazine therapies are available both as oral delayed-release and sustained-release formulation, topical formulations and as prodrug.Available literature regarding mesalazine is extensively reviewed in this article, covering its mechanism of action, pharmaceutics and pharmacokinetics, clinical efficacy, safety and tolerability in different settings.Mesalazine has a well-established role in the management of UC. It is the treatment of choice in active and inactive mild-to-moderate UC combinin…

Impact of cone-beam computed tomography for the identification and management of an oral portal of entry in patients with infective endocarditis. A D…

2021

Background Infective endocarditis (IE) is a rare and life-threatening disease. Cutaneous portal of entry (POE) is predominant for IE, but an oral POE is the second most frequent source. Thus looking for and treating an oral POE in IE patients is of critical importance in order to reduce the risk of IE relapse or recurrence. The objectives of this study were: 1) To reach a consensus on decision-making following the detection of an oral POE on cone-beam computed tomography (CBCT) while they were not identified using the current recommended approach in IE patients (oral examination and orthopantomogram: OPT). 2) To determine whether this consensus differs when regarding the microbiology of IE.…

Self-inflicted oral soft-tissue burn due to local behavior and treatment

2010

Injuries to oral soft-tissues can occur due to accidental, iatrogenic, and factitious traumas. They may present as burns, ulcerations, and gingival recession. Chemical, thermal, and physical agents are the main causative agents for oral soft-tissues burns. The purpose of this case report was to illustrate the destructive nature of the local behavior and to describe the successful treatment of this case. A 20-year-old girl with severe pain and burning sensation in the left maxillary region, which was interfering with normal eating and speaking, was admitted to periodontology clinic. Upon questioning, the patient readily admitted traumatizing her gingival and cheek mucosa with alcohol. Treatm…

Accuracy of computer-aided image analysis in the diagnosis of odontogenic cysts: A systematic review

2020

Background This study aimed to search for scientific evidence concerning the accuracy of computer-assisted analysis for diagnosing odontogenic cysts. Material and Methods A systematic review was conducted according to the PRISMA statements and considering eleven databases, including the grey literature. Protocol was registered in PROSPERO (CRD 42020189349). The PECO strategy was used to define the eligibility criteria and only studies involving diagnostic accuracy were included. Their risk of bias was investigated using the Joanna Briggs Institute Critical Appraisal tool. Results Out of 437 identified citations, five papers, published between 2006 and 2019, fulfilled the criteria and were i…

Glucagon-Like Peptide-1 Modulates Neurally-Evoked Mucosal Chloride Secretion in the Guinea Pig Ileum In Vitro

2011

Endoscopic mucosal resection: an evolving therapeutic strategy for non-polypoid colorectal neoplasia

2004

Endoscopic management for laterally spreading tumours of the colorectum is a safe and effective treatment and may be an alternative to surgery in selected patients Colorectal cancer develops in approximately 5–6% of the adult population and is one of the leading causes of cancer death in Europe and the USA.1,2 Screening colonoscopy is the widely accepted gold standard for early diagnosis of colorectal cancer and should be offered to patients older than 50 years.3–5 However, colonoscopy is increasingly in competition with computed tomographic virtual endoscopy.6 Therefore, it is essential to understand whether total colonoscopy rather than virtual endoscopy enables the detection of all relev…

Superficial esophageal cancer: endoscopic resection or radical surgery?

2010

Barrett's esophagus: endoscopic resection

2003

In experienced hands, ER is a safe method of resecting dysplastic lesions and early carcinomas of the GI tract, and it has decisive advantages compared with other local endoscopic treatment procedures (such as thermal destruction and PDT). The opportunity for histological processing of the resected specimen provides information regarding the depth of invasion of the individual layers of the GI tract wall. Additionally, it has advantages regarding excision with healthy margins. This means that even when there is infiltration of the submucosa that has not been detected before treatment--in which case local endoscopic therapy is no longer appropriate--a patient with early Barrett's cancer stil…

Oral lichen planus and its relationship with systemic diseases. A review of evidence

2018

Background Oral lichen planus (OLP) is one of the most common dermatological diseases which are present in the oral cavity. It is a chronic autoimmune, mucocutaneous disease that affects the oral mucosa as well as the skin, genital mucosa and other sites. Objective Review the relevant information to OLP and its relationship with systemic diseases. Material and Methods Searches were carried out in the Medline/PubMed, Lilacs, Bireme, BVS, and SciELO databases by using key-words. After an initial search that provided us with 243 papers, this number was reduced to 78 from the last seven years. One of the first criteria adopted was a selective reading of the abstracts of articles for the elimina…