Search results for "MULTIPLE"
showing 10 items of 2678 documents
Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis
2021
Background: Serum neurofilament light chain (sNfL) is a promising biomarker to complement the decision-making process in multiple sclerosis (MS) patients. However, although sNfL levels are able to detect disease activity and to predict future disability, the growing evidence has not yet been translated into practicable recommendations for an implementation into clinical routine. Methods: The observation of a patient with extensive inflammatory activity in magnetic resonance imaging (MRI) along with an extremely high sNfL level in the absence of any clinical symptoms prompted us to investigate common characteristics of our MS patients with the highest sNfL levels in a retrospective cohort st…
Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines
2001
Recently discovered chemically modified tetracyclines (CMTs) have shown in vitro and in vivo anti-proliferative and anti-tumour activities. Here, we evaluated in vitro the anti-proliferative and apoptotic activity of six different dedimethylamino chemically modified tetracyclines (CMT-1, CMT-3, CMT-5, CMT-6, CMT-7 and CMT-8) in sensitive and multidrug resistant myeloid leukaemia cells (HL60 and HL60R) in vitro. Three of these compounds (CMT-5, CMT-6, CMT-7) showed low cytotoxic activity both in sensitive and in resistant cells, CMT-3 was endowed with a high anti-proliferative activity only in sensitive cells and was moderately effective as apoptosis inducing agent, with an activity similar …
Exon deletions of the phenylalanine hydroxylase gene in Italian hyperphenylalaninemics
2009
A consistent finding of many studies describing the spectrum of mutant phenylalanine hydroxylase (PAH) alleles underlying hyperphenylalaninemia is the impossibility of achieving a 100% mutation ascertainment rate using conventional gene-scanning methods. These methods include denaturing gradient gel electrophoresis (DGGE), denaturing high performance liquid chromatography (DHPLC), and direct sequencing. In recent years, it has been shown that a significant proportion of undetermined alleles consist of large deletions overlapping one or more exons. These deletions have been difficult to detect in compound heterozygotes using gene-scanning methods due to a masking effect of the non-deleted al…
Ultrafast Fault-Tolerant Long-Distance Quantum Communication with Static Linear Optics
2017
We present an in-depth analysis regarding the error resistance and optimization of our all-optical Bell measurement and ultrafast long-distance quantum communication scheme proposed in [arXiv:1503.06777]. In order to promote our previous proposal from loss- to fault-tolerance, we introduce a general and compact formalism that can also be applied to other related schemes (including non-all-optical ones such as [PRL 112, 250501]). With the help of this new representation we show that our communication protocol does not only counteract the inevitable photon loss during channel transmission, but is also able to resist common experimental errors such as Pauli-type errors (bit- and phase-flips) a…
Low-lying level structure of Cu56 and its implications for the rp process
2017
The low-lying energy levels of proton-rich Cu56 have been extracted using in-beam γ-ray spectroscopy with the state-of-the-art γ-ray tracking array GRETINA in conjunction with the S800 spectrograph at the National Superconducting Cyclotron Laboratory at Michigan State University. Excited states in Cu56 serve as resonances in the Ni55(p,γ)Cu56 reaction, which is a part of the rp process in type-I x-ray bursts. To resolve existing ambiguities in the reaction Q value, a more localized isobaric multiplet mass equation (IMME) fit is used, resulting in Q=639±82 keV. We derive the first experimentally constrained thermonuclear reaction rate for Ni55(p,γ)Cu56. We find that, with this new rate, the …
Transition probability ratios for selected multiplets of C I, N I, and O I, and comparisons with recent calculations
2000
With a wall-stabilized high-current arc, we have measured the transition probabilities of several multiplet pairs of C I, N I, and O I. Pairs have been selected for which two recent ab initio calculations have produced widely different results. All chosen multiplets are among the prominent, strong features of their respective spectra, and the pairing is in each case done for multiplets that hardly differ in their excitation energies. Our results do not favor either of the calculations, but are consistent with an earlier experiment.
Duty-ratio control of Nonlinear phase noise in dispersion-managed WDM transmissions using RZ-DPSK modulation at 10 Gb/s
2006
International audience; The authors compare analytical and numerical estimates, showing that the nonlinear phase noise of short optical pulses associated with the coupling between amplified spontaneous emission noise and fiber nonlinearity may be controlled by adjusting the duty cycle of the return-to-zero (RZ) signal modulation format. The impact of this effect in the optimization of the performance of 10-Gb/s dispersion-managed wavelength division multiplexed (WDM) systems using RZ-differential phase-shift keying (DPSK) modulation is discussed. By extensive numerical simulations, it is shown that the transmission quality of ultradense WDM systems using the RZ-DPSK modulation format may be…
Angular Momentum Coupling
2007
In nuclear physics, as also in atomic and molecular physics, the entities to be described consist of sub-entities with some orbital angular momentum and spin. The angular momentum of the entity is built, then, of the angular momenta of the sub-entities. This building process leads to quantum-mechanical angular momentum coupling. This chapter presents the basic machinery for treating angular momentum and its coupling. Clebsch-Gordan coefficients and 3j symbols are introduced. It is shown that Clebsch-Gordan coefficients and 3j symbols relate to the coupling of two angular momenta. Increasing the number of angular momenta to be coupled leads to more complicated coupling patterns. Transformati…
Transfer of optical orbital angular momentum to a bound electron
2016
Photons can carry angular momentum, not only due to their spin, but also due to their spatial structure. This extra twist has been used, for example, to drive circular motion of microscopic particles in optical tweezers as well as to create vortices in quantum gases. Here we excite an atomic transition with a vortex laser beam and demonstrate the transfer of optical orbital angular momentum to the valence electron of a single trapped ion. We observe strongly modified selection rules showing that an atom can absorb two quanta of angular momentum from a single photon: one from the spin and another from the spatial structure of the beam. Furthermore, we show that parasitic ac-Stark shifts from…
Axisymmetric solutions for a chemotaxis model of Multiple Sclerosis
2018
In this paper we study radially symmetric solutions for our recently proposed reaction–diffusion–chemotaxis model of Multiple Sclerosis. Through a weakly nonlinear expansion we classify the bifurcation at the onset and derive the amplitude equations ruling the formation of concentric demyelinating patterns which reproduce the concentric layers observed in Balò sclerosis and in the early phase of Multiple Sclerosis. We present numerical simulations which illustrate and fit the analytical results.