Search results for "MULTIPLE"
showing 10 items of 2678 documents
Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses.
2020
Abstract Background Carnosic acid (CA) is one of the main constituents in rosemary extract. It possesses valuable pharmacological properties, including anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer activities. Numerous in vitro and in vivo studies investigated the anticancer profile of CA and emphasized its potentiality for cancer treatment. Nevertheless, the role of multidrug-resistance (MDR) related mechanisms for CA's anticancer effect is not yet known. Purpose We investigated the cytotoxicity of CA against known mechanisms of anticancer drug resistance (P-gp, ABCB5, BCRP, EGFR and p53) and determined novel putative molecular factors associated with cellular response to…
Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells.
2015
Abstract Background: The antihypertensive reserpine is an indole alkaloid from Rauwolfia serpentina and exerts also profound activity against cancer cells in vitro and in vivo. The present investigation was undertaken to investigate possible modes of action to explain its activity toward drug-resistant tumor cells. Material and methods: Sensitive and drug-resistant tumor cell lines overexpressing P-glycoprotein (ABCB1/MDR1), breast cancer resistance protein (ABCG2/BCRP), mutation-activated epidermal growth factor receptor (EGFR), wild-type and p53-knockout cells as well as the NCI panel of cell lines from different tumor origin were analyzed. Reserpine's cytotoxicity was investigated by res…
Inhibition of ATP-Binding Cassette Transporters by Chinese Herbs and Phytochemicals
2012
The gene family of ATP-binding cassette (ABC) transporters is widely distributed over the evolutionary tree of life from bacteria to man. In cancer, several ABC transporters are involved in the transport of anticancer drugs. This leads to the development of resistance to a broad spectrum of anticancer agents, termed multidrug resistance. An attractive strategy to overcome multidrug resistance is to block the transport function of ABC transporters leading to lethal intracellular concentrations of anticancer drugs. Efforts to identify transport inhibitors lead to a huge amount of chemical substances, none of which successfully passed clinical trials in cancer patients because of high toxicity…
Liver and gastrointestinal cancers
2020
Abstract One important limitation in the treatment of liver and gastrointestinal cancers is their poor response to available chemotherapy, which is due in part to efficient mechanisms of defense against antitumor drugs. An important role in chemoresistance is played by ATP-binding cassette (ABC) proteins, normally involved in barrier/secretory functions of the digestive apparatus. ABC pumps, often up-regulated in cancers derived from these organs, actively export antitumor agents from cancer cells, thereby reducing the pharmacological effect of these drugs. Among the ABC proteins with the highest impact on the multidrug resistance (MDR) phenotype of many cancer types is MDR1 or P-glycoprote…
Indefinite integrals involving the incomplete elliptic integral of the third kind
2016
ABSTRACTA substantial number of new indefinite integrals involving the incomplete elliptic integral of the third kind are presented, together with a few integrals for the other two kinds of incomplete elliptic integral. These have been derived using a Lagrangian method which is based on the differential equations which these functions satisfy. Techniques for obtaining new integrals are discussed, together with transformations of the governing differential equations. Integrals involving products combining elliptic integrals of different kinds are also presented.
Odontogenic abscess complicated by descending necrotizing mediastinitis: evidence of medical and dental malpractice
2016
Detection of 4T1(P) quartet of Co2+ in Zn99.95Co0.05Se monocrystal by optical absorption spectroscopy
2003
Abstract Optical absorption spectra of Zn 99.95 Co 0.05 Se were recorded at 25 K. The thickness and the concentration of cobalt were adjusted to obtain sharp d–d ∗ transitions of Co 2+ corresponding not only to multiplets of 4 T 1 (P) but also to higher excited states. For the first time, a very weak quartet splitting of 4 T 1 (P) state was clearly observed and these states were located between 1.464 and 1.517 eV. Higher series of energy states were found to lie in the range 1.98–2.108 eV which are expected on the basis of theoretical calculations but were not detected before and they were tentatively assigned to a lower multiplet of 2G configuration of free ion. The next series of transiti…
Effect of Multiple Stressors on marine organism predicted and quantified through bioenergetic mechanistic models
Anthropogenic pressure on coastal ecosystems is vast and diverse, simultaneous impacts such as pollution, eutrophication and fishing pressure nowadays add up and interact with the effects of climate change (e.g., global warming, acidification and sea level rise). The magnitude of these effects on marine species and their replies can vary and the possible changes can depend on: i) species life-histories (LH) traits, ii) local environmental conditions and iii) contextual presence of more than one anthropogenic related stressor. The study of a single anthropogenic disturbance or Climate Change-derived alteration on multi-level ecological responses is misleading and generates unrealistic conclu…
New insights regarding Acinetobacter genomic island-related elements
2020
The objective of this study was to mobilize the Acinetobacter genomic island 1-A (AGI1-A) from Enterobacter hormaechei EclCSP2185 (E. cloacae complex) and to search for the distribution and structure of AGI1-related elements in the NCBI database. AGI1-A was transferred to Escherichia coli. Analysis of the attachment (att) sites could locate the possible recombination crossover in the att sequences at position 10-11 (GG) in the last 18 bp of trmE. In silico detection of AGI backbones in the wgs database identified AGI variants in Salmonella enterica (83 strains), Vibrio cholerae (33), E. hormaechei (12), Acinetobacter baumannii (2), most belonging to prevalent clones (ST40, ST69, ST114 and S…
Multidrug-resistant Gram-negative post-neurosurgical meningitis and the role of intraventricular colistin: a case series
2021
: The aim of this study was to report the clinical experience of intraventricular colistin for the treatment of multi-resistant Gram-negative post-surgical meningitis in a tertiary hospital. Post-neurosurgical meningitis (PNM) is one of the life-threatening complications of neurosurgical procedures, and is frequently sustained by Acinetobacter baumannii and Klebsiella pneumoniae. Here we describe our experience of five cases of PNM caused by gram-negative multi-drug resistant (MDR) bacteria, treated with intraventricular (IVT) colistin, admitted to the Neurosurgery Unit of A.R.N.A.S. Civico of Palermo, Italy, from January 2016 to June 2020. In four patients the cerebrospinal fluid (CSF) cul…