Search results for "MVA"

Tramvaju kustības radīto atmosfēras aerosolu izcelsmes un izplatības novērtējums Rīgā

2021

Bakalaura darbā raksturota atmosfēras piesārņojuma problemātika, īpaša uzmanība pievērsta videi draudzīgākajam satiksmes veidam – tramvaju satiksmei. Tramvaju radītais cieto daļiņu (PM10, PM2,5) atmosfēras piesārņojums analizēts vērtējot dažādus aspektus – ekspluatētais tramvaja modeļa veids, kustības režīms, papildus vērtēta arī meteoroloģisko apstākļu ietekme. Eksperimentālā daļa realizēta Rīgā, veicot tiešos mērījumus laika periodā no 2020. gada rudens līdz 2021.gada pavasarim, tādējādi mērījumi tika veikti 3 dažādās sezonās, dažādos meteoroloģiskajos apstākļos, mainīga novietojuma un noslogotatības maršruta daļās.

Ezetimibe, cardiovascular risk and atherogenic dyslipidaemia.

2010

Ezetimibe is a selective cholesterol absorption inhibitor with an excellent side-effect profile, able to reduce low-density lipoprotein (LDL) cholesterol by 15-25% from baseline in monotherapy and on top of statins and fibrates. Yet, it seems that ezetimibe produces quantitative rather than qualitative changes in LDL, with small net effects on atherogenic dyslipidaemia. This is supported by findings from the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study on atherosclerosis progression, where the addition of ezetimibe to simvastatin in patients with heterozygous familial hypercholesterolaemia did not affect the mean change in carotid int…

Nogludinošo daļiņu hidrodinamikas metodes izpēte un lietojums

2021

Šis darbs ir veltīts nogludinošo daļiņu hidrodinamikas metodes izpētei un pielietojumam degšanas procesa simulācijai. Darbā tiek aprakstīta SPH metode, izpētītas SPH metodes aproksimācijas īpašības. Tiek apskatīts Eilera vienādojums, Navje-Stoksa vienādojums, siltumvadīšanas vienādojums un to atrisinājumi, izmantojot SPH metodi. Darbā tiek sastādīts degšana procesa modelis, pielietota SPH metode un aprakstīti rezultāti. Simulācijas tiek veiktas programmās MATLAB un OCTAVE.

Reakcijas - difūzijas vienādojuma izpēte degšanas procesa modelēšanā

2019

Darbā ir izvēlēts degšanas procesa matemātiskais modelis, un aplūkots siltumvadīšanas vienādojums cilindriskajās koordinātēs ar siltumavotu. Tiek iegūts precīzais atrisinājums, izmantojot mainīgo atdalīšanas metodi. Izmantojo programmu MATLAB, tiek atrasts skaitliskais atrisinājums ar galīgo diferenču aizklāto metodi. Tiek veikta iegūto rezultātu validācija, un izvēlētā soļa lieluma atkarības analīze. Darba beigās tiek apskatīta arī nelineāra problēma, kad tiek pievienots siltumavots. Programmā MATLAB tiek veiktas nelineārās problēmas dažādas simulācijas.

Software Startups – A Research Agenda

2016

Software startup companies develop innovative, software-intensive products within limited timeframes and with few resources, searching for sustainable and scalable business models. Softwarestartups are quite distinct from traditional mature software companies, but also from micro-,small-, and medium-sized enterprises, introducing new challenges relevant for software engineeringresearch. This paper’s research agenda focuses on software engineering in startups, identifying,in particular, 70+ research questions in the areas of supporting startup engineering activities,startup evolution models and patterns, ecosystems and innovation hubs, human aspects in softwarestartups, applying startup conc…

Desarrollo de la «Guía de consenso para el uso de medicamentos en insuficiencia renal»☆

2017

The effects of ezetimibe on LDL-cholesterol: quantitative or qualitative changes ?

2009

Ezetimibe represents the first of a new class of agents, the cholesterol absorption inhibitors, able to reduce low-density lipoproteins (LDL)-cholesterol by 15-25% from baseline in monotherapy and on top of statins and fibrates. To-date all the data regarding the efficacy of ezetimibe comes from the studies of its lipid-lowering power. Yet, recent findings from the ENHANCE study on atherosclerosis progression showed that the addition of ezetimibe to simvastatin in patients with heterozygous familial hypercholesterolemia did not affect the mean change in carotid intima-media thickness, although a significant reduction in LDL-cholesterol levels was present. Therefore, we cannot exclude that e…

A Multi-Variate Predictability Framework to Assess Invasive Cardiac Activity and Interactions during Atrial Fibrillation

2017

Objective: This study introduces a predictability framework based on the concept of Granger causality (GC), in order to analyze the activity and interactions between different intracardiac sites during atrial fibrillation (AF). Methods: GC-based interactions were studied using a three-electrode analysis scheme with multi-variate autoregressive models of the involved preprocessed intracardiac signals. The method was evaluated in different scenarios covering simulations of complex atrial activity as well as endocardial signals acquired from patients. Results: The results illustrate the ability of the method to determine atrial rhythm complexity and to track and map propagation during AF. Conc…

Efficacy, safety and tolerability of combined low-dose simvastatin-fenofibrate treatment in primary mixed hyperlipidaemia.

2007

In order to assess the long-term (12 months) efficacy and safety of fenofibrate administered with simvastatin in the treatment of primary mixed hyperlipidaemia, we conducted a study that compared increasing dosages of these drugs in subgroups of men and women belonging to a clinical sample of outpatients. This was an open study carried out in patients with primary mixed hyperlipidaemia (lipoprotein phenotype IIb) who needed a combined therapeutic approach because of their poor response to a single-drug regimen with an HMG-CoA reductase inhibitor (simvastatin). Thus, a fibrate (fenofibrate) was added to the therapy. The study lasted 12 months. Forty-five patients (mean age: 58.9 ± 11.3 years…

Ezetimibe/Simvastatin 10/20 mg Versus Rosuvastatin 10 mg in High Risk Hypercholesterolemic Patients Stratified by Previous Statin Treatment Potency

2010

Objective: This post-hoc analysis compared the lipid-altering efficacy of Ezetimibe/Simvastatin 10/20 mg (EZ/Simva) versus Rosuvastatin 10 mg (Rosuva) in patients stratified by statin potency/dose prior to randomization. Methods: Patients with elevated low-density lipoprotein cholesterol (LDL-C) despite prior statin treatment (n = 618) were randomized 1:1 to EZ/Simva 10/20 mg or Rosuva 10 mg for 6 weeks. Percent change from baseline in lipids and attainment of lipid targets were assessed within each subgroup (low potency n = 369, high potency n = 249). Consistency of the treatment effect across subgroups was evaluated by testing for treatment-by-subgroup interaction. No multiplicity adjustm…