Search results for "MYC"
showing 10 items of 3773 documents
Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.
2015
AbstractMyc promoter-binding protein-1 (MBP-1) is a shorter protein variant of the glycolytic enzyme alpha-enolase. Although several lines of evidence indicate that MBP-1 acts as a tumor suppressor, the cellular mechanisms and signaling pathways underlying MBP-1 expression still remain largely elusive. To dissect these pathways, we used the SkBr3 breast cancer cell line and non-tumorigenic HEK293T cells ectopically overexpressing alpha-enolase/MBP-1. Here, we demonstrate that induced cell stresses promote MBP-1 expression through the AKT/PERK/eIF2α signaling axis. Our results contribute to shedding light on the molecular mechanisms underlying MBP-1 expression in non-tumorigenic and cancer c…
Per-protocol repeat kidney biopsy portends relapse and long-term outcome in incident cases of proliferative lupus nephritis
2019
Abstract Objectives In patients with LN, clinical and histological responses to treatment have been shown to be discordant. We investigated whether per-protocol repeat kidney biopsies are predictive of LN relapses and long-term renal function impairment. Methods Forty-two patients with incident biopsy-proven active proliferative (class III/IV±V) LN from the database of the UCLouvain were included in this retrospective study. Per-protocol repeat biopsies were performed after a median [interquartile range (IQR)] time of 24.3 (21.3–26.2) months. The National Institutes of Health activity index (AI) and chronicity index (CI) scores were assessed in all biopsies. Results Despite a moderate corre…
SAT-429 Systemic Safety Analysis of Mycophenolate in Graves’ Orbitopathy
2020
Abstract Context The dual antiproliferative mechanism of mycophenolate appears to be beneficial in Graves’ orbitopathy (GO). Methods The safety data, which is of utmost importance in immunomodulation, from the two major randomized mycophenolate trials [“Chinese trial” (1) and “European Group on Graves’ Orbitopathy (EUGOGO) trial” (2)] and the original database of the EUGOGO trial were systematically analyzed. Treatment efficacy stratified by individual visual parameters of clinical disease activity and severity were also compared. Results A total of 129 adverse events (AE) involving 50 patients (29.4%) were noted among all mycophenolate-treated patients. Mycophenolate sodium plus intravenou…
Specific and global regulation of mRNA stability during osmotic stress in Saccharomyces cerevisiae.
2009
Hyperosmotic stress yields reprogramming of gene expression in Saccharomyces cerevisiae cells. Most of this response is orchestrated by Hog1, a stress-activated, mitogen-activated protein kinase (MAPK) homologous to human p38. We investigated, on a genomic scale, the contribution of changes in transcription rates and mRNA stabilities to the modulation of mRNA amounts during the response to osmotic stress in wild-type and hog1 mutant cells. Mild osmotic shock induces a broad mRNA destabilization; however, osmo-mRNAs are up-regulated by increasing both transcription rates and mRNA half-lives. In contrast, mild or severe osmotic stress in hog1 mutants, or severe osmotic stress in wild-type cel…
Influence of nitrogen status in wine alcoholic fermentation
2019
Nitrogen is an essential nutrient for yeast during alcoholic fermentation. Nitrogen is involved in the biosynthesis of protein, amino acids, nucleotides, and other metabolites, including volatile compounds. However, recent studies have called several mechanisms that regulate its role in biosynthesis into question. An initial focus on S. cerevisiae has highlighted that the concept of "preferred" versus "non-preferred" nitrogen sources is extremely variable and strain-dependent. Then, the direct involvement of amino acids consumed in the formation of proteins and volatile compounds has recently been reevaluated. Indeed, studies have highlighted the key role of lipids in nitrogen regulation in…
Non-neoplasic and non-syndromic palatal perforations. Presentation of 5 cases and systematic review of the literature
2021
Background Palatal perforations not associated with syndromes or neoplasms are rare lesions whose frequency has increased recently. However, their clinical and demographic characteristics have not been fully described. Therefore, this report aimed to establish the demographic and clinical characteristics of patients with non-syndromic and non-neoplastic palatal perforations. Material and Methods The file of an oral medicine teaching clinic from January 2004 to December 2018 was reviewed to identify and isolate all cases with a diagnosis of palatal perforation. Cases with a diagnosis of palatal perforation related to congenital alteration, syndrome, or neoplasia were excluded. Age, sex, medi…
Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.
2017
Urm1 is a unique dual-function member of the ubiquitin protein family and conserved from yeast to man. It acts both as a protein modifier in ubiquitin-like urmylation and as a sulfur donor for tRNA thiolation, which in concert with the Elongator pathway forms 5-methoxy-carbonyl-methyl-2-thio (mcm5s2) modified wobble uridines (U34) in anticodons. Using Saccharomyces cerevisiae as a model to study a relationship between these two functions, we examined whether cultivation temperature and sulfur supply previously implicated in the tRNA thiolation branch of the URM1 pathway also contribute to proper urmylation. Monitoring Urm1 conjugation, we found urmylation of the peroxiredoxin Ahp1 is suppre…
Effet de la nutrition et du génotype sur les réponses de défense chez Medicago truncatula
2014
Les organismes phytopathogènes sont responsables de la destruction d’environ 30% des récoltes. Malgré leur impact négatif sur l’environnement et la santé humaine, les produits phytosanitaires restent un des principaux moyens de lutte. Dans un cadre général de diminution de l’utilisation de ces produits, mon projet de thèse a pour objectif de mieux comprendre l’effet de la nutrition de la plante et de son génotype sur les mécanismes moléculaires impliqués dans ses réponses de défense vis-à-vis des pathogènes et ceci afin de définir des stratégies de lutte innovantes. Etude de l’effet des carences nutritionnelle sur la signalisation cellulaire et moléculaire des réponses de défense par analys…
Análisis de las rutas de señalización de nutrientes en cepas vínicas de Saccharomyces cerevisiae en condiciones de vinificación
2019
Tesis doctoral presentada por Beatriz Vallejo Estará para optar al grado de Doctora por la Universitat de València.
Acaulospora sieverdingii, an ecologically diverse new fungus in the Glomeromycota, described from lowland temperate Europe and tropical West Africa
2011
International audience; From a survey of arbuscular mycorrhizal (AM) fungi in agro-ecosystems in Central Europe and West Africa, an undescribed species of Acaulospora was recovered and is presented here under the epithet Acaulospora sieverdingii. Spores of A. sieverdingii are 60-80 mu m in diam, hyaline to subhyaline to rarely light yellow and have multiple pitted depressions on the outer spore wall similar to those known for A. alpina, A. cavernata, A. paulinae and A. scrobiculata. The pits in A. sieverdingii are tiny and often irregular and resemble small dots (0.8-1.8 mu m) or lines (0.5-1.2 x 1.8-2.5 mu m). Analyses of the ITS1, 5.8S subunit and ITS2 regions of the rDNA resolved each of…