Search results for "Mace"
showing 10 items of 4713 documents
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment
2023
Despite the significant outcomes attained by scientific research, breast cancer (BC) still represents the second leading cause of death in women. Estrogen receptor-positive (ER+) BC accounts for the majority of diagnosed BCs, highlighting the disruption of estrogenic signalling as target for first-line treatment. This goal is presently pursued by inhibiting aromatase (AR) enzyme or by modulating Estrogen Receptor (ER) α. An appealing strategy for fighting BC and reducing side effects and resistance issues may lie in the design of multifunctional compounds able to simultaneously target AR and ER. In this paper, previously reported flavonoid-related potent AR inhibitors were suitably modified…
Ergonomiskie riski un hroniska noguruma sindroms farmaceitiem. Preventīvie pasākumi
2015
Maģistra darbā ir pētīti ergonomiskie darba vides riska faktori farmaceita darbā un to saistība ar hronisko noguruma sindromu farmaceitiem. Darbs sastāv no trīs daļām. Pirmajā daļā analizēta literatūra par pētāmo tēmu, otrajā daļā aprakstītas pētījumā pielietotās metodes, trešajā daļā veikta iegūto rezultātu analīze. Literatūras analīze liecina, ka farmaceitus darbā ietekmē šādi darba vides riski: nelabvēlīgs mikroklimats, troksnis, apgaismojums, bioloģiskie, ķīmiskie, ergonomiskie, kā arī psihoemocionālie riski. Darbā pielietotas mūsdienīgas ergonomiska risku un hroniska noguruma indeksa noteikšanas metodes. Iegūtie rezultāti apliecina, ka farmaceiti darbā pamatā pakļauti ergonomiskiem ris…
Hronisko brūču un čūlu terapija farmaceita praksē
2019
Bieži brūču dzīšanu kavē vai ietekmē to veidošanas dažādas citas saslimšanas: cukura diabēts, hroniska vēnu mazspēja, perifēro artēriju slimība. Darba mērķis bija noskaidrot hronisku brūču un čūlu aktualitāti, ārstēšanas un profilakses iespējas farmaceita praksē, analizējot 2018.– 2019.gada aptaujas rezultātus. Darbā tika analizētas 63 pacientu un 75 farmaceitu aptauju atbildes, kā arī 7 speciālistu intervijas, pēc kurām tika noskaidrota pēdu problēmas, kāju un pēdu kopšana profilakse, kā arī brūču ārstēšanas metodes un aprūpe (pārsēji, antibakteriālas līdzekļi, kompresijas zeķes). Pēc aptaujas rezultātiem secināts, ka 44% no tiem bija cukura diabēta pacienti. Svarīga ir ne tikai brūču ārst…
HYALURONIC ACID/-CYCLODEXTRINS HYDROGEL FOR CORNEAL RELEASE OF EPITHELIAL CELLS AND DEXAMETHASONE
2015
HYALURONIC ACID-graft-ELASTIN BASED SCAFFOLDS FOR POTENTIAL TISSUE ENGINEERING APPLICATIONS
2012
Hyaluronic acid based hydrogel and use thereof in surgery
2012
Variations in the Chemical Composition of the Essential Oil of Lavandula angustifolia Mill., Moldoveanca 4 Romanian Variety
2020
International audience; In this research, the variations in the chemical composition of the Lavandula angustifolia Mill. essential oil, the Romanian variety Moldoveanca 4, obtained from the same culture, in the same harvesting and extraction conditions, during the years 2016-2018, representing the years 2-4 of culture. Lavandula angustifolia Mill. flowers were supplied from an ecological-crops from N-E Romania and the essential oils were obtained by hydro distillation of freshly harvested flowers. To determine the chemical composition, the essential oil was semi-quantitatively analysed by using gas chromatography coupled with mass spectrometry (GC-MS). In all the samples, 30 organic compoun…
Biocompatible Hydrogels Based on Hyaluronic Acid Cross-Linked with a Polyaspartamide Derivative as Delivery Systems for Epithelial Limbal Cells
2011
Medicated hydrogels of hyaluronic acid derivatives for use in orthopedic field
2013
Experimental FTIR-MI and Theoretical Studies of Isocyanic Acid Aggregates
2023
Homoaggregates of isocyanic acid (HNCO) were studied using FTIR spectroscopy combined with a low-temperature matrix isolation technique and quantum chemical calculations. Computationally, the structures of the HNCO dimers and trimers were optimized at the MP2, B3LYPD3 and B2PLYPD3 levels of theory employing the 6-311++G(3df,3pd) basis set. Topological analysis of the electron density (AIM) was used to identify the type of non-covalent interactions in the studied aggregates. Five stable minima were located on the potential energy surface for (HNCO)2, and nine were located on the potential energy surface for (HNCO)3. The most stable dimer (D1) involves a weak, almost linear N-H⋯N hydrog…