Search results for "Mace"

Psoriāzes ārstēšanai paredzēto medikamentu aprite divās Rīgas aptiekās 2014 - 2015.gadā un farmaceita loma psoriāzes pacientu aprūpes procesā

2016

Psoriāze ir autoimūna, hroniska ādas iekaisuma slimība, kas skar 2 – 3% pasaules iedzīvotāju. Ādas bojājumus raksturo eritēma, epidermāla hiperplāzija un ādas plaisāšana. Maģistra darba mērķis ir veikt psoriāzes medikamentu apriti par 2 gadu periodu (2014. gads – 2015. gads) aptiekās: A – 11 un A – 42 un, izmantojot pacientu anketēšanas metodi, noskaidrot farmaceita lomu psoriāzes pacientu aprūpes procesā. Medikamentu aprites dati rāda, ka vislielāko patēriņa daļu 2014. un 2015. gadā sastāda kortikosteroīdus saturoši medikamenti: “Daivobet” gels (Calcipotriolum/Betamethazonum) – 52% (2014. gads) un 51% (2015. gads), “Elosalic” ziede (Mometasoni furoas/Acidum Salicylicum) – 26% (2014. gads) …

Apoptotic induction on HeLa tumor cell line. A comparison of activity between pyrazolo[1,2-a]benzo[1,2,3,4]tetrazinone derivatives and their syntheti…

2009

Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors

2023

The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compounds 27, 29, 30, 33, 37, 38, and 41 were chosen for the synthesis based on the results of the in silico screening. Each of the synthesized compounds was tested for its in vitro antibacterial and antifungal activities using a variety of strains. All the compounds showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus pyogenes) as well as Gram-negativ…

Synthesis and antitumor activity of new tetracyclic systems containing the pyrrole ring.

2012

Targeted synthesis of pyrrolo tricycles for selective biomolecules overexpressed in cancer cells

2009

3-[2-(1H-Indol-3-yl)-1,3-thiazol-4-yl)-1H-pyrrolo[3,2-b]pyridine: a new series of kinase inhibitors

2009

Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species

2022

Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the Lamiaceae family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and su…

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery.

2022

The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists com…

Radiolabeling of Nanoparticles and Polymers for PET Imaging

2014

Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screeni…

SOIGNER AUX FRONTIÈRES : REGARD PSYCHODYNAMIQUE SUR LE QUOTIDIEN TRAUMATIQUE DES SOIGNANTS/RÉFUGIÉS

2017

Les soignants d’hôpitaux habitant et travaillant aux frontières turco-syriennes sont aussi des migrants ou des réfugiés syriens. Comme la population sinistrée, ils exercent leur activité professionnelle au rythme de la guerre et nécessitent également un accompagnement. Dans le cadre de l’Unité psychosociale d’une ONG internationale, un soutien psychologique en visio-conférence est proposé aux soignants en Syrie et en Turquie. Cet article propose un commentaire et une réflexion clinique sur le quotidien de ces soignants, leur santé mentale, ainsi que sur leurs mécanismes de survie psychiques, groupaux et culturels. Quatre vignettes cliniques sont commentées et discutées pour comprendre la co…