Search results for "Mace"

showing 10 items of 4713 documents

Performance Improvements of EventIndex Distributed System at CERN

2023

El trabajo de esta tesis se enmarca dentro del proyecto EventIndex del experimento ATLAS, un gran detector de partı́culas del LHC (Gran Colisionador de Hadrones) en el CERN. El objetivo del proyecto es catalogar todas las colisiones de partı́culas, o eventos, registrados en el detector ATLAS y también simulados a lo largo de sus años de funcionamiento. Con este catálogo se pueden caracterizar los datos a nivel de evento para su búsqueda y localización por parte de los usuarios finales. También se pueden realizar comprobaciones en la cadena de registro y reprocesado de los datos, para comprobar su corrección y optimizar futuros procesos. Debido al incremento en las tasas y volumen de datos e…

storagedistributed computingUNESCO::CIENCIAS TECNOLÓGICAS::Tecnología de los ordenadores ::Dispositivos de almacenamientobig dataDetectors and Experimental TechniquesgridUNESCO::CIENCIAS TECNOLÓGICAS::Tecnología de los ordenadores ::Arquitectura de ordenadoresComputing and Computers
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Il fitochimico indicaxantina previene stress ossidativo, arresto del ciclo cellulare ed apoptosi indotta da 7-Ketocolesterolo in monociti-macrofagi u…

2012

PHYTOCHEMICAL INDICAXANTHIN PREVENTS 7-ketoCHOLESTEROL-INDUCED OXIDATIVE STRESS, CELL CYCLE ARREST AND APOPTOSIS IN HUMAN MONOCYTES- MACROPHAGES.

stress ossidativomonociti-macrofagi umani in coltura.arresto del ciclo cellulareapoptosiSettore CHIM/08 - Chimica Farmaceutica
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Stress darbā farmaceitiem un tā novēršanas pamatprincipi

2019

Šī darba mērķis bija pētīt stresa cēloņus farmaceitu darbā, izmantojot objektīvas un subjektīvas metodes stresa novērtēšanai darbavietās un izstrādāt preventīvos pasākumus stresa cēloņu novēršanā. Iegūtie rezultāti norāda, ka farmaceitu darbā ir sastopami dažādi stresa izraisītāji. Stresa cēļoņi ir saistīti ar farmaceitu darba specifiku un darbiniekiem esot pakļautiem dažādiem darba vides riska faktoriem, īpaši psihosociāliem un organizatoriskiem riska faktoriem. Secināts, ka pētījumā pielietotās metodes ir piemērotas iespējamo stresa cēloņu analīzei farmaceitu darbā un ir noderīgas pielietojumam, lai novērtētu ar stresu saistītos darba vides riskus un veiktu preventīvos pasākumus. Praktisk…

stressarodveselībafarmaceitistresoriFarmācijadrošība
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Darba vides riska faktoru un stresa ietekme uz Liepājas aptiekā strādājošo farmaceitu darba spējām

2019

Maģistra darbā ir pētīti darba vides riska faktori un stresa ietekme uz farmaceitiem, un to saistība ar nodarbināto darbspējām. Darbs sastāv no trīs daļām. Pirmajā daļā ir apkopota un analizēta literatūra par farmaceitu profesiju, kā arī ergonomiskiem un psihosociāliem riskiem. Otrajā daļā aprakstītas pētījumā lietotās metodes, bet trešajā daļā veikta iegūto rezultātu apkopošana un analīze. Literatūras analīze liecina, ka farmaceiti, kuri strādā aptiekā, pakļauti daudzveidīgiem darba vides risku faktoriem (fiziskiem, ergonomiskiem, psihosociāliem). Maģistra darbā, tika izmantotas Eiropā populāras darba vides risku un stresa līmeņu, novērtēšanas metodes. Iegūtie rezultāti uzrāda, ka farmacei…

stressfarmaceiti (pharmacists)Farmācijadarbspējas (working capacity)ergonomiskie riski (ergonomic risks)
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Compared Binding Properties between Resveratrol and Other Polyphenols to Plasmatic Albumin: Consequences for the Health Protecting Effect of Dietary …

2014

International audience; Phytophenols are considered to have beneficial effects towards human physiology. They are food microcomponents with potent chemopreventive properties towards the most three frequent contemporary human diseases, e.g., cardiovascular alterations, cancer and neurodegenerative pathologies. Related to this, the plasmatic form and plasmatic level of plant polyphenols in the body circulation are crucial for their efficiency. Thus, determinations of the binding process of resveratrol and of common flavonoids produced by major edible plants, berries and fruits to plasma proteins are essential. The interactions between resveratrol and albumin, a major plasma protein, were comp…

structural changes[SDV]Life Sciences [q-bio]Pharmaceutical ScienceReviewResveratrolresveratrol01 natural sciencesAnalytical Chemistryquercetinchemistry.chemical_compound[ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]Resveratrol bindingDrug DiscoveryStilbenesBovine serum albuminComputingMilieux_MISCELLANEOUS0303 health sciencesbiologyfood and beveragesBlood proteins[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]3. Good healthBiochemistryChemistry (miscellaneous)HealthMolecular MedicinefluorescencePlants EdibleQuercetinSerum albuminlcsh:QD241-44103 medical and health scienceslcsh:Organic chemistryHumans[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Physical and Theoretical ChemistryBinding siteSerum Albumin030304 developmental biologyFlavonoidsBinding Sites010405 organic chemistryOrganic ChemistryAlbuminPolyphenols0104 chemical sciencesDietchemistryFoodbiology.proteinaffinityMolecules
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Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of t…

2009

The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. Adding a methyl group at the C-3 position resulted in increased activity. The most prom…

structure-activityStereochemistryClinical BiochemistryPharmaceutical ScienceAntineoplastic Agentsmacromolecular substancesBiochemistryChemical synthesisArticleStructure-Activity Relationshipchemistry.chemical_compoundbenzo[b]furansMicrotubuleCell Line TumorFuranDrug DiscoveryHumansStructure–activity relationshipMolecular BiologyBenzofuransCell ProliferationBinding SitesDose-Response Relationship DrugbiologyChemistryTubulin ModulatorsCell growthCell CycleOrganic ChemistrySmall moleculeTubulin Modulatorstubulin polymerizationTubulinDrug Designbiology.proteinMolecular MedicineProtein MultimerizationColchicine
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Sviluppo di metodi analitico-tossicologici per la determinazione di PCDD/F e PCB in matrice ambientale. Livelli di contaminazione per la Regione Sici…

2012

studio dei profili di distribuzione.Settore CHIM/08 - Chimica Farmaceuticametodi analitico-tossicologici per la determinazione di PCDD/F e PCB in matrice ambientalelivelli di contaminazione
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Reverse Catmull-Clark Subdivision

2006

Reverse subdivision consists in constructing a coarse mesh of a model from a finer mesh of this same model. In this paper, we give formulas for reverse Catmull-Clark subdivision. These formulas allow the constructing of a coarse mesh for almost all meshes. The condition for being able to apply these formulas is that the mesh to be reversed must be generated by the subdivision of a coarse mesh. Except for this condition, the mesh can be arbitrary. Vertices can be regular or extraordinary and the mesh itself can be arbitrary (triangular, quadrilateral…).

subdivision surfacesComputer Science::Graphicsmultiresolutionmultirozlišenídělené plochyanimationMathematicsofComputing_NUMERICALANALYSISanimaceCatmull-Clark schemeCatmull-Clarckovo schémaComputer Science::DatabasesComputingMethodologies_COMPUTERGRAPHICSMathematics::Numerical Analysis
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Titanocene Selenide Sulfides Revisited: Formation, Stabilities, and NMR Spectroscopic Properties

2019

[TiCp2S5] (phase A), [TiCp2Se5] (phase F), and five solid solutions of mixed titanocene selenide sulfides [TiCp2SexS5−x] (Cp = C5H5−) with the initial Se:S ranging from 1:4 to 4:1 (phases B–E) were prepared by reduction of elemental sulfur or selenium or their mixtures by lithium triethylhydridoborate in thf followed by the treatment with titanocene dichloride [TiCp2Cl2]. Their 77Se and 13C NMR spectra were recorded from the CS2 solution. The definite assignment of the 77Se NMR spectra was based on the PBE0/def2-TZVPP calculations of the 77Se chemical shifts and is supported by 13C NMR spectra of the samples. The following complexes in varying ratios were identified in the CS2 solutions of …

sulfidit77Se-NMR spectroscopyPharmaceutical ScienceCrystal structureSulfidesorganometalliyhdisteet010402 general chemistry01 natural sciencesArticleAnalytical Chemistrylcsh:QD241-441Seleniumcrystal structureschemistry.chemical_compoundChalcogenlcsh:Organic chemistrytitanocene selenide sulfidesSelenide0103 physical sciencesDrug DiscoveryOrganometallic CompoundsCarbon-13 Magnetic Resonance SpectroscopyNMR-spektroskopiaPhysical and Theoretical Chemistryta116DLPNO-CCSD(T) calculations13C-NMR spectroscopyCrystallographyMolecular Structure010304 chemical physics<sup>13</sup>C-NMR spectroscopyChemistryChemical shiftOrganic ChemistryTitanocene dichlorideCarbon-13 NMRkiteetStandard enthalpy of formation0104 chemical sciencesNMR spectra databasetitaani<sup>77</sup>Se-NMR spectroscopyChemistry (miscellaneous)Carbon DisulfideseleeniQuantum TheoryMolecular MedicinePhysical chemistryMolecules
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Sulfonamide moiety as "molecular chimera" in the design of new drugs.

2021

Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…

sulfonamide moietyPharmacologyOrganic Chemistrymolecular chimeraSettore CHIM/08 - Chimica FarmaceuticaBiochemistrymolecular dynamicsin silico drug designdockingDrug Discoverypharmacophore modelingMolecular Medicinealkylsulfonamidesaryl/heteroarylsulfonamidesCurrent medicinal chemistry
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