Search results for "Macro"

Elements of Sustainability for Public Sector Software : Mosaic Enterprise Architecture, Macroservices, and Low-Code

2021

Public sector is a large consumer for software. In countries such as Finland, many of the systems are made to order by consultancy companies that participate in public tenders. These tenders initiated by the state, cities, and other public sector organizations. Furthermore, as public sector tasks are often decomposed to various actors, each and every one of them makes their purchase based on their own needs. In this paper, we argue that to maintain software sustainability in this context, there is a need for three key elements. Firstly, there is a need for an enterprise architecture where independent services from various vendors are can be easily deployed and integrated. Secondly, these se…

The transformation of R&D into neo open innovation- a new concept in R&D endeavor triggered by amazon

2019

Amazon was the world's top Research and Development (R&D) firm in 2017. Its R&D investment was double that of 2015, five times that of 2012, and ten times that of 2011. Such a rapid and notable increase in R&D investment has raised the question of a new R&D definition and focus in the digital economy, which Amazon insists includes both “routine or periodic alterations” (traditionally classified as non-R&D) and “significant improvement” (classified as R&D). Using an empirical analysis of Amazon's R&D model as a system, this paper attempts to provide a convincing answer to this question. It has been identified that Amazon, which is based on R&D as a culture, has been promoting companywide exp…

Addressing the Pandemic in the Philippines Necessitates a New Economic Paradigm

2020

Large Azobenzene Macrocycles : Formation and Detection by NMR and MS Methods

2023

Azobenzene macrocycles are widely investigated as potential drug delivery systems and as part of molecular machines due to their photo-responsive properties. Herein, we detect the formation of a series of new azobenzene macrocycles that feature up to eight switchable repeating units. High-resolution mass spectrometry and ion mobility (IM) mass spectrometry experiments and 1H and diffusion-ordered spectroscopy (DOSY) NMR are used to detect the presence of the macrocycles that contain 10 to 40 aromatic rings in the gas phase and solution, respectively. The responsiveness of the Z-to-E photo-switching of the smallest of the macrocycles, exhibiting two azobenzene units and in total 10 aromatic …

The seaweeds Fucus vesiculosus and Ascophyllum nodosum are significant contributors to coastal iodine emissions

2013

Based on the results of a pilot study in 2007, which found high mixing ratios of molecular iodine (I2) above the intertidal macroalgae (seaweed) beds at Mweenish Bay (Ireland), we extended the study to nine different locations in the vicinity of Mace Head Atmospheric Research Station on the west coast of Ireland during a field campaign in 2009. The mean values of I2 mixing ratio found above the macroalgae beds at nine different locations ranged from 104 to 393 ppt, implying a high source strength of I2. Such mixing ratios are sufficient to result in photochemically driven coastal new-particle formation events. Mixing ratios above the Ascophyllum nodosum and Fucus vesiculosus beds increased …

Formulation of Different Chitosan Hydrogels for Cartilage Tissue Repair

2014

Different formulations of Chitosan/sulphate and Chitosan/PEGDE were produced by physical and chemical reticulation to obtain hydrogels with better physiochemical properties. The hydrogels were analyzed – in terms of their non-toxicity, proliferative, differentiative, inflammatory and immunology responses. Commercial grade Chitosan (Sigma) was solubilized and purified by progressive filtrations. Then, the polymer was freeze-dried in a water soluble cationic form. A physical hydrogel was prepared by mixing a 3 % w/w water solution of the a.m. polymer with different stoichiometric ratios of (SO4=) 1/0.5;1/0.75;1/1 respectively. The hydrogels were cross-linked in multiwells. The chemical hydrog…

The Influence of an Environment on the Content of Macro- and Microelements in the Tanacetum vulgare

2019

Tansy (Tanacetum vulgare L.) grows in moderate area of the northern hemisphere, in Poland – its range covers the whole country. It appears on the farm wastelands, by roadsides, on enbankments, river banks, forest lips and in open spaces. The present paper has faced the challenge of defining the influence of the environmental conditions on the mineral composition of Tanacetum vulgare leaves. The plants were picked in the blooming period from May to September 2017 in 12 natural environments of their growth and at different contamination levels. The dried and minced plant material was submitted to chemical analyses of the bio elements content (K, P, Cu, Zn, Mo) of leaves. A great variety was o…

A Cost–Benefit Based, Parametric Procedure to Screen Existing Irrigation and Municipal Supply Reservoirs for Wind Energy Storage

2018

Pumped hydro storage (PHS) is one of the more suitable energy storage technologies to provide bulk storage of intermittent renewable energy sources (RES) such as wind. Since the main limiting factors to the expansion of this mature technology are environmental and financial concerns, the use of an existing reservoir can help mitigate both types of impacts. In addition, the high number of reservoirs for municipal and irrigation supply in many areas of the world makes the idea of using PHS as a relatively diffuse, open-market, technology for RES management attractive. These arguments in favor of PHS must, however, be convincing for investors and regulators from an economic standpoint. To this…

Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity

2019

The Wnt signaling pathway is a conserved pathway involved in important cellular processes such as the control of embryonic development, cellular polarity, cellular migration, and cell proliferation. In addition to playing a central role during embryogenesis, this pathway is also an essential part of adult homeostasis. Indeed, it controls the proliferation of epithelial cells in different organs such as intestine, lung, and kidney, and guarantees the maintenance of the mucosa in physiological conditions. The origin of this molecular pathway is the binding between Wnt ligands (belonging to a family of 19 different homologous secreted glycoproteins) and their specific membrane receptors, from …

TLR7 controls VSV replication in CD169(+) SCS macrophages and associated viral neuroinvasion

2019

Vesicular stomatitis virus (VSV) is an insect-transmitted rhabdovirus that is neurovirulent in mice. Upon peripheral VSV infection, CD169+ subcapsular sinus (SCS) macrophages capture VSV in the lymph, support viral replication, and prevent CNS neuroinvasion. To date, the precise mechanisms controlling VSV infection in SCS macrophages remain incompletely understood. Here, we show that Toll-like receptor-7 (TLR7), the main sensing receptor for VSV, is central in controlling lymph-borne VSV infection. Following VSV skin infection, TLR7−/− mice display significantly less VSV titers in the draining lymph nodes (dLN) and viral replication is attenuated in SCS macrophages. In contrast to effects o…