Search results for "Magnetism"
showing 10 items of 1934 documents
EPR studies of the oxyfluoride glass ceramics using Mn2+as a paramagnetic probe
2010
In this work, we used Mn2+ as a dopant in the oxyfluoride glasses with various fluoride compounds. Electron paramagnetic resonance (EPR) measurements were carried out before and after a heat treatment of the material. In both cases, a well pronounced hyperfine (hf) structure of the EPR spectra characteristic to the Mn2+ ion have been observed. EPR measurements have also been studied for the separate fluoride counterparts of the oxyfluoride glasses. EPR spectra of the LaF3:Mn2+ and CaF2:Mn2+ powders show that Mn2+ ion has a strong superhyperfine (shf) interaction with surrounding fluorine nuclei, and this shf structure could be observed also in the heat treated glass samples.
Evaluation of the pH effect of formulations on the skin permeability of drugs by biopartitioning micellar chromatography☆
2004
Dermal absorption of chemicals is an area of increasing interest for the pharmaceutical and cosmetic industries, as well as in dermal exposure and risk assessment processes. Biopartitioning micellar chromatography (BMC) is a mode of reversed phase micellar chromatography that has proved to be useful in the description and prediction of several pharmacological properties of xenobiotics including oral drug absorption, ocular and skin drug permeability. The present paper deals with the application of biopartitionig micellar chromatography to evaluate the pH effect on the skin permeability of twelve non-steroidal anti-inflammatory drugs and lidocaine. For this purpose the BMC retention of the w…
Electric Field Control of Spin-Dependent Dissipative Electron Transfer Dynamics in Mixed-Valence Molecules
2015
We demonstrate that the borderline class II/III magnetic MV dimers, which can be referred to as single molecule multiferroics, provide a unique possibility to achieve electric field control of the electron transfer (ET) dynamics. As an example, we consider a MV dimer d2-d1 in which an extra electron is delocalized over two spin-cores (s0 = 1/2), and the ET is spin-dependent due to the double exchange mechanism. It is assumed that the “extra” electron is coupled to the only intramolecular vibration, and a weak coupling to the dissipative subsystem (thermal bath) is taken into account. The vibronic energy levels and the wave functions of the isolated dimer (quantum part of the system) are num…
Drug gastrointestinal absorption in rat: Strain and gender differences.
2015
Predictive animal models of intestinal drug absorption are essential tools in drug development to identify compounds with promising biopharmaceutical properties. In situ perfusion absorption studies are routinely used in the preclinical setting to screen drug candidates. The objective of this work is to explore the differences in magnitude and variability on intestinal absorption associated with rat strain and gender. Metoprolol and Verapamil absorption rate coefficients were determined using the in situ closed loop perfusion model in four strains of rats and in both genders. Strains used were Sprague-Dawley, Wistar-Han, Wistar-Unilever, Long-Evans and CD∗IGS. In the case of Metoprolol only…
Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients
2019
Dysphagia is a very common problem suffered by elderly patients. The use of thickeners during administration in these patients helps to prevent difficulties with swallowing larger solid dosage forms. However, there are several indications when the thickeners may influence disintegration and dissolution processes of solid dosage forms, potentially affecting therapeutic efficacy. In this paper the effects of a commonly used thickener on tablet disintegration, dissolution and subsequent absorption of 6 formulated drugs frequently used in elderly patients (Aspirin, Atenolol, Acenocumarol, Candesartan, Ramipril and Valsartan) in two different administration conditions (intact tablet and crushed …
An ex-vivo model for transsynovial drug permeation of intraarticular injectables in naive and arthritic synovium
2021
Abstract Estimation of joint residence time of a drug is a key requirement for rational development of intraarticular therapeutics. There is a great need for a predictive model to reduce the high number of animal experiments in early stage development. Here, a Franz-cell based porcine ex-vivo permeation model is proposed, and transsynovial permeation of fluorescently-labeled dextrans in the range of potential drug candidates (10–150 kDa), as well as a small molecule (fluorescein sodium) and charged dextran derivates, have been determined. In addition, a lipopolysaccharide (LPS) -induced synovitis model was assessed for inflammatory biomarker levels and its effect on permeation of the solute…
PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.
2018
The oral controlled release (CR) formulations have become more important in recent years. Among them, the polymeric nanoparticles have been thoroughly studied during the last decades, consequently they are extensively employed for a broad range of applications and drugs. The objective of this research was to develop polymeric nanoparticles (NPs) of ibuprofen with poly(lactic-co-glycolic) acid (PLGA) as polymer, and to test their applicability for oral CR formulations development. Different proportions of drug/polymer were employed to develop the ibuprofen NPs and their in vitro release profiles were analysed. The in situ segmental permeability of ibuprofen was tested in Wistar rat and demon…
Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers
2017
In this work a new copolymer of inulin (INU) derivatized with ethylendiamine (EDA) and retinoic acid (RA), named INU-EDA-RA, was synthetized, characterized and employed to produce micelles as carriers for topical administration of corticosteroids for the potential treatment of diseases of posterior eye segment. Spectroscopic analysis confirmed a molar derivatization degree of 11.30 and 4.30% in EDA and RA, respectively. INU-EDA-RA micelles are capable of strong mucoadhesive interactions which result time-independent and stable over time but concentration depending. Moreover micelles are able to encapsulate efficiently from 3 to 13% (w/w) of lipophilic drugs, as dexamethasone, triamcinolone …
Measurements of the Generalized Electric and Magnetic Polarizabilities of the Proton at LowQ2Using the Virtual-Compton-Scattering Reaction
2006
Experimental details of a virtual Compton scattering (VCS) experiment performed on the proton at the MIT-Bates out-of-plane scattering facility are presented. The VCS response functions ${P}_{LL}\ensuremath{-}{P}_{TT}/\phantom{{P}_{TT}\ensuremath{\varepsilon}}\ensuremath{\varepsilon}$ and ${P}_{LT}$ have been measured at ${Q}^{2}=0.057\phantom{\rule{0.28em}{0ex}}{\mathrm{GeV}}^{2}/{c}^{2}$. The generalized electric and magnetic polarizabilities, $\ensuremath{\alpha}({Q}^{2})$ and $\ensuremath{\beta}({Q}^{2})$, and the mean-square electric polarizability radius$\ensuremath{\langle}{r}_{\ensuremath{\alpha}}^{2}\ensuremath{\rangle}$ are obtained from a dispersion analysis of the data. The resu…
The behavior of the 180° domain walls in disordered dielectrics like KTaO3 : Li and KTaO3 : Nb
2003
We calculate the structure of 180° domain wall in disordered ferroelectrics with random site electric dipoles (i.e. those like K 1-x Li x TaO 3 , KTa 1-x Nb x O 3 , where Li + or Nb 5+ are off-center ions forming impurity dipoles). The calculation is performed on the base of the free energy functional of disordered dielectrics derived earlier [M. D. Glinchuk et al., Phase Transit., 2003 (to be published)] within the framework of a random field method. We obtain the domain wall thickness as a function of impurity dipole concentration n and temperature T. It is shown that in disordered ferroelectrics the domain wall is usually broader than in their ordered counterparts. The thickness increase…