Search results for "Main"

showing 10 items of 4384 documents

Genesi geometrica delle volte centriche

1996

Un'analisi completa degli organismi voltati comporta lo studio delle molteplici componenti necessarie alla loro definizione: configurazione geometrica, sistema costruttivo, area storico-geografica di appartenenza, interpretazioni Stilistiche. L’obiettivo di questo studio è indirizzato all' analisi delle volte continue su pianta centrica definibili attraverso le leggi della geometria euclidea. L’indagine si pone all'interno dei confini relativi alla loro configurazione geometrica e il criterio adottato, svincolato da classificazioni di carattere tipologico o stilistico, propone l'identificazione di famiglie geometriche in base alla figura del poligono di base dell'impianto. Si può identifica…

A comprehensive analysis of vaulted bodies involves the study of the multiple components necessary for their definition: geometric configuration construction system historical-geographical area of belonging interpretations Stylistic. The objective of this study is directed to the 'analysis of continuous vaults on a centric plan definable through the laws of Euclidean geometry. The investigation arises within the boundaries related to their geometric configuration and the criterion adopted freed from typological or stylistic classifications proposes the identification of geometric families based on the figure of the basic polygon of the plant. An ordering process can be identified to explain the compositional process of curved-roofed central plants: that is the elaboration of a series of theoretical models developed according to an abacus referring to the basic geometries of the triangle square and pentagon is possible. It is not intended to impose a classification but to propose a study tool that thanks to a few simple compositional rules develops a very large number of configurationthe question remains as to why only a part has been used for the realization of vaulted covered centric buildings but this presumes considerations of a historical formal and constructive nature extraneous to this discussion.Settore ICAR/17 - Disegno
researchProduct

MAST-RT0 SOLUTION OF 3D NAVIER STOKES EQUATIONS ON UNSTRUCTURED MESHS. PRELIMINARY RESULTS IN THE LAMINAR CASE

2021

A new numerical solver for the 3D Navier Stokes incompressible laminar problems is proposedThe governing equations are discretized over unstructured tetrahedral mesheThe proposed model is suitable for the solution of laminar flows in irregular domainsDelaunay mesh condition is not requiredSettore ICAR/01 - Idraulica
researchProduct

MAST-RT0 solution of 3D Navier Stokes equations in very irregular domains. Preliminary results in the laminar case

2021

A new numerical methodology to solve the 3D Navier-Stokes equations for incompressible fluids within complex boundaries and unstructured body-fitted tetrahedral mesh is presented and validated with three literature and one real-case tests. We apply a fractional time step procedure where a predictor and a corrector problem are sequentially solved. The predictor step is solved applying the MAST (Marching in Space and Time) procedure, which explicitly handles the non-linear terms in the momentum equations, allowing numerical stability for Courant number greater than one. Correction steps are solved by a Mixed Hybrid Finite Elements discretization that assumes positive distances among tetrahedr…

A new numerical solver for the 3D Navier Stokes incompressible laminar problems is proposedThe proposed model is suitable for the solution of laminar flows in irregular domainsSettore ICAR/01 - Idraulica
researchProduct

Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial

2021

Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…

A ActionDGOJ Directorate General for the Regulation of GamblingCIDI Composite International Diagnostic InterviewPA Positive AffectSPIRIT Standard Protocol Items Recommendations for Interventional TrialsefficacyPsychological interventionMotivational interviewingGE Gambling ExpectanciesDSM-IV Diagnostic and Statistical Manual of Mental Disorders Fourth EditionOASIS The Overall Anxiety Severity and Impairment Scalelaw.inventionDERS Difficulties in Emotion Regulation ScaleRandomized controlled triallawPANAS The Positive and Negative Affect SchedulePsychologyRCT Randomized Controlled TrialUPPS-P The Short UPPS-P Impulsivity ScaleICD-10 International Statistical Classification of Diseases and Related Health Problems 10th RevisionCognitionT58.5-58.64GRCS-S Gambling-Related Cognitions ScalePC Predictive ControlBF1-990EDBs Emotion Driven BehavioursC ContemplationGSEQ Gambling Self-Efficacy QuestionnaireDSM-5 Diagnostic and Statistical Manual of Mental Disorders Fifth EditionAnxietyAddicció a Internetmedicine.symptomMI Motivational InterviewingPsychologyJocs per ordinadorM Maintenancemedicine.medical_specialtyemotion regulationG-SAS The Gambling Symptom Assessment ScaleEMA Ecological Momentary AssessmentODSIS The Overall Depression Severity and Impairment ScaleEfficacyWL Waiting ListIC Illusion of ControlIB Interpretative BiasMFS Monitoring Feedback and SupportCBTHealth InformaticsInformation technologyCBT Cognitive Behavioral TherapyImpulsivityCONSORT-EHEALTH Consolidated Standards of Reporting Trials of Electronic and Mobile Health Applications and Online TelehealthISG Perceived Inability to Stop GamblingQuality of life (healthcare)URICA The University of Rhode Island Change Assessment ScaleIntervention (counseling)medicineGD Gambling DisorderSCID-P The Structured Clinical InterviewPsychiatryQLI Quality Life IndexInternetEmotion regulationFull length ArticleSUS System Usability ScalegamblingEMI Ecological Momentary InterventionMINI Mini International Neuropsychiatric InterviewGI Gambling history interview and current gambling situation and related variables assessmentNA Negative AffectGamblingNODS NORC DSM-IV Screen for Gambling ProblemsPFIs Personal Feedback InterventionsDSM-III-R Diagnostic and Statistical Manual of Mental Disorders 3rd Edition RevisedHADS Hospital Anxiety Depression ScaleinternetP Precontemplation
researchProduct

Abstract C75: Overcoming KRAS/LKB1 mutant NSCLC resistance to BET bromodomain inhibitors with gemcitabine or Mcl-1 inhibition

2015

Abstract The purpose of our study was to define a method and mechanism for overcoming the resistance of clinically relevant KRAS-mutant/LKB1-deficient NSCLC cells to the BET-bromodomain inhibitor JQ1. LKB1 (Serine/threonine kinase 11) is mutated with loss of function in conjunction with mutated KRAS in 7-10% of NSCLC. Importantly, KRAS-mutant/LKB1-deficiency is associated with tumor aggressiveness and poor survival in human patients as well as in genetically engineered mouse models. Indeed, although the BET bromodomain inhibitor JQ1 dramatically reduces tumor volume in KRAS mutant mice, it has little effect in KRAS-mutant/LKB1-deficient mice. BET bromodomain proteins are chromatin readers t…

A549 cellCancer ResearchGene knockdownKinaseBiologymedicine.disease_causeGemcitabineBromodomainOncologyApoptosisImmunologymedicineCancer researchOncogene MYCKRASneoplasmsmedicine.drugMolecular Cancer Therapeutics
researchProduct

Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging

2005

Processing of amyloid precursor protein (APP) is a well acknowledged central pathogenic mechanism in Alzheimer disease. However, influences of age-associated cellular alterations on the biochemistry of APP processing have not been studied in molecular detail so far. Here, we report that processing of endogenous APP is down-regulated during the aging of normal human fibroblasts (IMR-90). The generation of intracellular APP cleavage products C99, C83, and AICD gradually declines with increasing life span and is accompanied by a reduced secretion of soluble APP (sAPP) and sAPPalpha. Further, the maturation of APP was reduced in senescent cells, which has been shown to be directly mediated by a…

ADAM10NicastrinEndogenyBiochemistryCell LineAmyloid beta-Protein PrecursorMembrane MicrodomainsDownregulation and upregulationEndopeptidasesmental disordersPresenilin-1Amyloid precursor proteinAspartic Acid EndopeptidasesHumansSecretionMolecular BiologyCellular SenescenceMembrane GlycoproteinsbiologyChemistryMembrane ProteinsCell BiologyFibroblastsCholesterolBiochemistrybiology.proteinAmyloid Precursor Protein SecretasesProtein Processing Post-TranslationalAmyloid precursor protein secretaseIntracellularJournal of Biological Chemistry
researchProduct

Trichuris trichiura egg extract proteome reveals potential diagnostic targets and immunomodulators.

2021

The proteomic analysis was performed at the proteomics facility of SCSIE, University of Valencia (Burjassot, Spain) that belongs to ProteoRed, PRB2-ISCIII, Madrid, Spain. We also thank Dr. Tatiana Corey, Dr. Amy Beierschmitt and Dr. Pompei Bolfa for their support during sample collection.

ADULT WORMSSerum ProteinsProteomePhysiologyProteomesEggsRC955-962Egg proteinBiochemistryHeat Shock ResponseMedical ConditionsReproductive PhysiologyArctic medicine. Tropical medicineINFECTIONChlorocebus aethiopsMedicine and Health SciencesSUPEROXIDE-DISMUTASECellular Stress ResponsesImmune System ProteinsbiologySoil-transmitted helminthiasisHelminth ProteinsNEMATODEBird EggsInfectious DiseasesTrichurisCell ProcessesHelminth InfectionsProteomeFemaleAntibodyPublic aspects of medicineRA1-1270EXCRETORY-SECRETORY PRODUCTSResearch ArticleNeglected Tropical DiseasesTrichuriasisImmunologyMicrobiologyVitellogeninProtein Domainsparasitic diseasesmedicineParasitic DiseasesHEAT-SHOCK PROTEINSAnimalsHumansTrichuriasisPARASITEOvumImmunodiagnosticsMOLECULAR-CLONINGIDENTIFICATIONPublic Health Environmental and Occupational HealthBiology and Life SciencesProteinsMASS-SPECTROMETRYCell Biologymedicine.diseasebiology.organism_classificationTropical DiseasesSoil-Transmitted HelminthiasesAntigens Helminthbiology.proteinTrichuris trichiuraPLoS Neglected Tropical Diseases
researchProduct

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
researchProduct

Students’ Perceptions of Family Entrepreneurship – A Study on Family Business Academic Education

2010

L’objectif de cette recherche est d’analyser les points de vue d’étudiants universitaires envers la condition des entrepreneurs. Le fond théorique analyse l’interaction entre l’entreprise familiale, le propriétaireship, et l’éducation sur la condition des entrepreneurs. 211 étudiants de l’Université de Jyväskylä ont participé à cette étude pendant le cours fondamental de Basic business studies appelé “Introduction to Entrepreneurship and Business Operations” en septembre 2007. 143 d’entre eux ont écrit un essai d’une page, soit en finnois soit en anglais, sur les entreprises familiales et les propriétaires familiales. Les étudiants ont écrit sur le phénomène avec leurs propres mots. Les rés…

Academic educationEntrepreneurshipSocial Sciences and Humanitiesfamily businesscontent analysiseducación en iniciativa empresarialéducation de la condition des entrepreneurspedagogyFamily businessGeneral Medicineentreprise familialeanalyse de content.Political sciencepédagogieempresa familiarEthnologySciences Humaines et SocialesHumanitiespedagogía análisis de contenidosentrepreneurship educationManagement international
researchProduct

Molecular mechanisms of endomembrane trafficking in plants

2021

Abstract Endomembrane trafficking is essential for all eukaryotic cells. The best-characterized membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus, early and recycling endosomes, multivesicular body, or late endosome, lysosome/vacuole, and plasma membrane. Although historically plants have given rise to cell biology, our understanding of membrane trafficking has mainly been shaped by the much more studied mammalian and yeast models. Whereas organelles and major protein families that regulate endomembrane trafficking are largely conserved across all eukaryotes, exciting variations are emerging from advances in plant cell biology research. In this review, …

AcademicSubjects/SCI01280EndosomeENDOPLASMIC-RETICULUMGolgi ApparatusPlant ScienceSUSPENSION-CULTURED CELLSBiologyDOMAIN-CONTAINING PROTEINSEndoplasmic ReticulumEndocytosissymbols.namesakeLysosomeAutophagymedicineEndomembrane systemVACUOLAR TRAFFICKINGPlant Physiological PhenomenaLate endosomeAcademicSubjects/SCI01270AcademicSubjects/SCI02288AcademicSubjects/SCI02287Endoplasmic reticulumAcademicSubjects/SCI02286AutophagyBiology and Life SciencesBiological TransportRETICULUM EXPORT SITESCell BiologyGolgi apparatusCLATHRIN-MEDIATED ENDOCYTOSISEndocytosisFocus on Cell BiologyCell biologyTRANS-GOLGI NETWORKEditorialmedicine.anatomical_structureP24 FAMILY PROTEINSMEMBRANE TRAFFICKINGPLASMA-MEMBRANEVacuolessymbolsThe Plant Cell
researchProduct