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showing 10 items of 4384 documents
Towards the new spectral-domain optical coherence tomography based classification of age-related macular degeneration
2012
Abstract Introduction Age-related macular degeneration (AMD) is major social and health problem in industrialised societies. The contribution of the new diagnostic techniques, mainly spectral-domain optical coherence tomography (SD-OCT), has led to a better understanding of this disease. Aim To review the current clinical classification of AMD, to describe the new tomographic classification of wet AMD, and to review the new topographical findings in dry AMD. Development There are two classically described forms of AMD: dry and wet; there are also three progressive stages of severity: early, intermediate and advanced. This purely clinical stratification does not take into account any criteri…
α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
2009
The Swedish mutation within the amyloid precursor protein (APP) causes early-onset Alzheimer's disease due to increased cleavage of APP by BACE1. While beta-secretase shedding of Swedish APP (APPswe) largely results from an activity localized in the late secretory pathway, cleavage of wild-type APP occurs mainly in endocytic compartments. However, we show that liberation of Abeta from APPswe is still dependent on functional internalization from the cell surface. Inspite the unchanged overall beta-secretase cleaved soluble APP released from APP(swe) secretion, mutations of the APPswe internalization motif strongly reduced C99 levels and substantially decreased Abeta secretion. We point out t…
Maintenance therapy in gastro-oesophageal reflux disease.
2005
Gastro-oesophageal reflux disease (GORD) is a chronic condition. Symptom control and the maintenance of healing of erosive oesophagitis, if present, are important topics. In patients responding to a proton pump inhibitor (PPI) and showing no treatment symptoms it is appropriate to consider long-term treatment strategies, whether continuous, intermittent or on demand. Maintenance PPI therapy is well tolerated for up to 10 years of continuous use. Furthermore, tachyphylaxis does not occur during long-term maintenance PPI therapy. Previous concerns about risks of long-term PPI therapy in Heliobacter pylori-negative or H. pylori-positive patients have not materialized, while no cases of intesti…
Selective RAR agonists for acne vulgaris: A narrative review.
2019
Background Acne vulgaris is a chronic disfiguring inflammatory disease of adolescents and adults affecting up to 90% of the population around the world. The sequence of etiopathogenesis in acne is not completely understood but involves abnormalities in sebum production, follicular plugging, proliferation of propionibacterium acnes, and chronic inflammation. Aims This review aims to summarize the features of the topical selective RAR agonists in treating acne vulgaris with a special emphasis on the 4th generation topical retinoid trifarotene. Methods Studies were identified by searching electronic databases (MEDLINE and PubMed) till August 2019 and reference lists of respective articles. Onl…
Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
2015
The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic nerve. The retina is formed by the association of the neurosensory retina and the retinal pigment epithelium that is supported by Bruch’s membrane. Both the physical and metabolic associations between these partners are crucial for the functioning of the retina, by means of nutrient intake and removal of the cell and metabolic debris from the retina. Dysequilibrium are involved in the aging processes and pathologies such as age-related macular degeneration, the leading cause of visual loss after the age of 50 years inWestern countries. The retina is composed of severa…
A Non-Interventional Study of Tiotropium/Olodaterol versus Any Triple Combination Therapy for Chronic Obstructive Pulmonary Disease: The EVELUT® Stud…
2020
Roland Buhl,1 Michael Dreher,2 Stephanie Korn,1 Christian Taube,3 Christian Stock,4 Christoph M Zehendner,5 Anke Kondla,5 Claus F Vogelmeier6 1Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, Germany; 2Clinic of Cardiology, Pneumology, Angiology and Internal Medicine Intensive Care, University Hospital RWTH Aachen, Aachen, Germany; 3Clinic for Pneumonology, University Medicine Essen – Ruhrlandklinik, Essen, Germany; 4Biostatistics + Data Sciences Corp, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany; 5HP Country Medical Affairs, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany; 6Department of Pneumology,…
Reliability and validity of time domain heart rate variability during daily rout¡ne activities : an alternative to the morning orthostatic test?
2017
Summary Study aim: To determine the reliability and validity of a time domain heart rate variability (HRV) index during free-living physical activity (FLPA). Material and methods: Eight white-collar workers participated in this study. RR intervals (time between consecutive R-peaks of the PQRS complex) were recorded using the Polar V800 heart rate (HR) monitor upon awakening and at work on 16 different days. A total of 127 cycles of sitting periods followed by walking breaks were included for consecutive pairwise analysis for reliability. The HR values from the orthostatic test (OT) were compared with the corresponding values at work. Results: The HR values showed high levels of repeatabilit…
Quadrature domains for the Helmholtz equation with applications to non-scattering phenomena
2022
In this paper, we introduce quadrature domains for the Helmholtz equation. We show existence results for such domains and implement the so-called partial balayage procedure. We also give an application to inverse scattering problems, and show that there are non-scattering domains for the Helmholtz equation at any positive frequency that have inward cusps.
Gestion des ressources naturelles dans le Pays de Tulle : impacts paysagers et histoire du châtaignier (Castanea sativa Mill.) de l'Antiquité à la Re…
2013
Este artículo presenta los resultados paleoambientales de los primeros análisis palinolójicos y sedimentológicos llevados a cabo en el area de Tulle (Mars, Gimel-les-Cascades, Corrèze, Francia). Se basan en la comparación de distintos indicadores bióticos (polen, microfósiles no polínicos) y sedimentarios y en la realización de 9 dataciones radiocarbónicas. Esta investigación establece datos inéditos sobre las dinámicas paisajísticas desde la Antigüedad y sus factores de control tanto climáticos como antrópicos. También analiza de que manera estos cambios paisajísticos pueden significar el desarrollo de sistemas de uso diversificados de los recursos vegetales como el cultivo del castaño (Ca…
Isolation and characterization of microsatellite markers in the liver fluke (Fasciola hepatica)
2004
PRIMER NOTE; International audience; Six microsatellite markers were isolated from Fasciola hepatica, a re-emerging parasite that causes important veterinary and public health problems. In a sample of 52 liver flukes from a region of hyperendemicity (Bolivian Altiplano), five microsatellite were polymorphic. Our results showed that liver flukes present important genetic variability, suggesting a preferential outcrossing reproduction mode for this hermaphroditic parasite.