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Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin s…
1994
Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol…
economics in the mirror of the financial crisis
2011
The structure of the Chapter is as follows. In Section 2 I discuss some of the factors that may have played a role in causing the crisis and emphasise that supporters of different economic theories will assign different weights to each factor in their analyses. As a consequence, suggested economic policies are highly sensitive to the economic theory employed in evaluating the set of causes. In Section 3 I seek to defend economists from the common charge that their inability to foresee the crisis is a clear sign of the lack of scientific status of their discipline. In my view, the main liability of mainstream economics lies elsewhere, in its excessive trust on the self-equilibrating mechanis…
Port-en-Bessin et Commes, le mont Castel
2014
International audience
Un dieu peut-il mourir ? Enquête sur la fin des cultes dans l’Antiquité gréco-romainedirigé par Karin Mackowiak et Christian Stein
2018
La résidence de Montmartin (Oise) du III au IIe s. av. J.-C.
1997
Le rôle du marché des dirigeants dans le système de gouvernance des entreprises : une revue de la littérature
2005
National audience; L'objectif de cet article est, en s'appuyant sur la littérature existante, d'appréhender et de comprendre le rôle d'un mécanisme particulier:le marché des dirigeants, à l'intérieur du système de gouvernance des entreprises. La grille de lecture utilisée est synthétique, permettant d'étudier les voies d'intervention potentielles du marché managérial aussi bien sous la dimension disciplinaire que cognitive. L'apport principal de cet article est d'aboutir à une vision globale et complète du rôle de ce mécanisme, venant remettre en cause la perception généralement négative du marché des dirigeants, considéré inefficient, de type clanique, notamment en France. Cette revue cons…
Towards CCTV-aware Routing and Navigation for Privacy, Anonymity, and Safety - Feasibility Study in Jyväskylä
2021
AbstractIn order to withstand the ever-increasing invasion of privacy by CCTV cameras and technologies, on par CCTV-aware solutions must exist that provide privacy, safety, and cybersecurity features. We argue that a first important step towards such CCTV-aware solutions must be a mapping system (e.g., Google Maps, OpenStreetMap) that provides both privacy and safety routing and navigation options. Unfortunately, to the best of our knowledge, there are no mapping nor navigation systems that support CCTV-privacy and CCTV-safety routing options. At the same time, in order to move the privacy vs. safety debate related to CCTV surveillance cameras from purely subjective to data-driven and evide…
Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
2020
Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …
Einsame Ruhe in unberührter Natur : Vorstellungen von Reisewerbebildern der Region Kainuu : eine Befragungsuntersuchung unter potenziellen deutschen…
2006
Noturīgās un mainīgās fonētiskās īpatnības Dundagas izloksnē
2015
Bakalaura darba tēma ir „Noturīgās un mainīgās fonētiskās īpatnības Dundagas izloksnē”. Dundagas izloksne pieder pie Kurzemes lībiskā dialekta dziļajām tāmnieku izloksnēm. Darbā pētīta Dundagas novada vienas konkrētas apdzīvotās vietas – Kaļķu ciema – iedzīvotāju runa, analizējot audioierakstos saklausāmās un brīvās sarunās dzirdētās fonētiskās īpatnības. Bakalaura darba mērķis ir apzināt noturīgās un mainīgās fonētiskās īpatnības Dundagas izloksnē, balstoties uz 2014. un 2015. gada ierakstiem, salīdzināt ar senākos avotos fiksētām fonētiskām parādībām, tāpat arī citām dziļo tāmnieku izloksnēm. Pielikumā pievienoti izloksnes teksti fonētiskā transkripcijā.