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Lower thoracic spine extension mobility is associated with higher intensity of thoracic spine pain
2022
Objectives: To evaluate the association of thoracic spine (TS) posture and mobility with TS pain. Methods: Participants with TS pain reported maximum, average, and night pain in TS area, and pain summary score was calculated. Upright and sitting TS postures were evaluated by inspection. TS posture and mobility (flexion and extension) were recorded using an inclinometer and a tape measure, respectively. Correlations between posture and mobility assessments were calculated using Spearman rank correlation, the association of TS posture and mobility with TS pain by logistic regression analysis. Results: The participants’ (n = 73, 52 females, age range 22–56) TS pain duration was 12 weeks on ave…
Cardiorespiratory Fitness and the Risk of Serious Ventricular Arrhythmias: A Prospective Cohort Study.
2019
Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed using a respiratory gas exchange analyzer in 2299 middle-aged men in the Kuopio Ischemic Heart Disease prospective cohort. We corrected for within-person variability in CRF levels using data from repeated measurements 11 years apart. During median follow-up of 25.3 years (interquartile range, 18.7-27.2 years), 73 serious VAs were recorded. The age-…
Long-term safety of nine systemic medications for psoriasis: A cohort study using the Spanish Registry of Adverse Events for Biological Therapy in De…
2020
Background: Registry studies broadly describing the safety of systemic drugs in psoriasis are needed. Objective: To describe the safety findings of the systemic drugs acitretin, adalimumab, apremilast, cyclosporine, etanercept, infliximab, methotrexate, secukinumab, and ustekinumab used for the treatment of moderate to severe psoriasis in patients included in the Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases (BIOBADADERM) Registry. Methods: The incidence rate ratio (IRR) and adjusted IRR (including propensity scores) of identified adverse events for each drug, using methotrexate as reference, were determined by means of a prospective cohort. Results: O…
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging
2011
Objective To determine whether pulsed Doppler examination of the ductus venosus in rat fetuses could damage exposed tissue. Methods On gestational day 18, the livers of a mean of approximately five fetuses per mother (n = 5.14, SD = 1.6), in a cohort of 35 pregnant female rats, were exposed individually to pulsed Doppler and these were considered the 'exposed group'. The remaining fetuses in each pregnant rat (n = 5.16, SD = 2.1) formed the 'control group'. We tested for 600, 300, 60, 20, 15, 10 and 3 s of exposure of the fetal ductus venosus and the damage was evaluated measuring a cell death index of apoptotic activity at 7 h post-exposure (n = 16). In addition, subgroups of mothers were …
Suurkasvillisuus jokien ekologisen tilan arvioinnissa
2012
Suomen vesienhoitolaki edellyttää pintavesien ekologisen tilan arviointia ja seurantaa. Laki perustuu Euroopan Unionin vesipolitiikan puitedirektiiviin, jonka tavoitteena on jäsenmaiden vesistöjen erinomainen tai hyvä tila viimeistään vuoteen 2027 mennessä. Ekologisen tilan arviointi perustuu ensisijaisesti biologisiin laatutekijöihin. Suurkasvit, eli vesisammalet, suurlevät ja vedessä kasvavat putkilokasvit, ovat yksi virtavesien ekologisen tilan arvioinnissa käytettävä elementti. Tässä tutkimuksessa pyrittiin kehittämään Suomen jokien suurkasvillisuuden tilan arviointia. Tavoitteena oli suurkasviyhteisöjen luonnollisen vaihtelun kuvaaminen, vaihtelun lähteiden tunnistaminen ja näihin peru…
Bryophyte diversity in semi-natural grasslands : the effects of habitat quantity and quality
2015
Edeltäneiden vuosisatojen maatalouskäytännöt loivat elinympäristöjä, joihin tänä päivänä viitataan perinnebiotooppeina. Siirtymä moderniin maatalouteen on muiden maankäytön muutosten ohella vähentänyt näitä biologisesti, kulttuurisesti ja sosiaalisesti arvokkaita elinympäristöjä murto-osaan entisestä. Perinnebiotoopeille tyypillinen avoimuus, vähäravinteisuus ja säännölliset häiriöt tekevät niistä biologisesti monimuotoisia elinympäristöjä. Perinnebiotooppien pinta-alan pienenemisen ja pirstoutumisen seurauksena on ollut useiden lajien uhanalaistuminen. Jäljellä olevien perinnebiotooppien laatua uhkaa etenkin hoidon riittämättömyys. Sammalet ovat kooltaan pieniä ja ekologialtaan riippuvaisi…
Upotreblenie pričastij v gazetno-publicističeskom i oficial’no-delovom stilâh
2013
Tämän pro-gradu-tutkielman aiheena ovat venäjän kielen partisiipit. Teema on ajankohtainen, koska puhekielessä partisiippien käyttö on hyvin vähäistä ja vastaavasti tutkimukseen valitussa sanomalehtityylissä ja virallisessa asiatyllissä partisiippeja käytetään laajasti. Työn päätavoitteena on tarkastella partisiippien esiintymistä ja niiden käytön erityispiirteitä sanomalehti- ja virallisessa asiatyylissä. Tutkimusaineistona käytetään ko. tyylejä edustavia tekstejä, jotka on kerätty venäjän kielen kansalliskorpuksesta (Ruscorpora). Työn tulokset voivat olla hyödyllisiä venäjän kielen opettajille ja kääntäjille.Tutkimuksen teoriaosuudessa käydään läpi partisiippien yleispirteitä, niiden muod…
Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women
2020
In midlife, women experience hormonal changes due to menopausal transition. A decrease especially in estradiol has been hypothesized to cause loss of muscle mass. This study investigated the effect of menopausal transition on changes in lean and muscle mass, from the total body to the muscle fiber level, among 47–55-year-old women. Data were used from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, where 234 women were followed from perimenopause to early postmenopause. Hormone levels (estradiol and follicle stimulating hormone), total and regional body composition (dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans), physical activity level (self-reported…
Environmental factors influencing the distribution and prevalence of Schistosoma haematobium in school attenders of ILembe and uThungulu Health Distr…
2017
Schistosoma haematobium infection is reported to facilitate the development of urogenital diseases. Its symptoms include haematuria, dysuria and tiredness, and it may cause cognitive decline in children. The prevalence of S. haematobium infection needs to be known in endemic areas and a mass treatment programme against the disease implemented. The aim of this study was to investigate the prevalence and intensity of S. haematobium infection in ILembe and uThungulu health districts, using the major symptom, haematuria, as an indicator. A total of 6 265 urine samples, from 96 rural schools, was collected for analysis using dipsticks. The prevalence of haematuria in the ILembe health district w…