Search results for "Mali"
showing 10 items of 3900 documents
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
METAPHOR IN THE XXth CENTURY: TWO WAYS OF INTERPRETING THE CONCEPT
2018
Resumen El objetivo de este artículo es resumir, a través del análisis de las fuentes teóricas principales, el desarrollo de dos tradiciones en la interpretación de la metáfora. Simbólicamente las podemos denominar: 1) Visión formalista, centrada en la descripción de los rasgos de la metáfora, su estructura formal y las funciones que desempeña en un texto o un discurso; y 2) Visión pragmática y cognitiva que propone comprender la metáfora en relación con la situación comunicativa, mostrando también su papel como una de las cadenas básicas del pensamiento humano. Abstract The aim of this article is to summarize, through the analysis of the main theoretical sources, the development of two way…
Migrazioni ed insediamenti informali: riflessioni sul caso siciliano
2022
Over the last fifty years, many European regions in the Mediterranean area, historically considered as areas of origin of international migration flows, have been transformed into places of reception. At the basis of this mobility is, among many factors, the demand, by a variable and globalised economy, for 'easy' labour, mostly made up of new immigrants, instrumental to that particular local economic system. Analysing the spatial dimension of the phenomenon, it highlights how the inadequacy and insufficiency of reception places and the increase in eviction phenomena contribute to the significant increase in the phenomenon of informal settlements in peripheral urban contexts, making it diff…
Il fenomeno migratorio e gli insediamenti informali, un focus sul territorio siciliano
2023
Il fenomeno dei flussi migratori, che da oltre vent'anni si registra in Europa in modo esponenzialmente crescente, ha rappresentato - e continua a rappresentare - un elemento di grande cambiamento nel quadro sociale europeo. Rispetto al suddetto scenario, i fenomeni di globalizzazione, le recenti trasformazioni socio-economiche e quelle del mercato del lavoro, sono alla base della convergenza di un articolato sistema di fattori interdipendenti che determinano il continuo mutamento dei rapporti tra paesi di origine e paesi di destinazione dei flussi migratori. Analizzando la dimensione spaziale, che mostra l'inadeguatezza e l'insufficienza dei luoghi di accoglienza e l'aumento dei fenomeni d…
On the null-subject phenomenon: an example of successful linguistic research
2018
This chapter deals with the history on the studies on null subjects, and on the most recent approaches.
Pseudo-relatives, gerunds and infinitives in Romance: (only) superficial resemblances and structural connections
2013
L'argomento di questa monografia è un confronto tra i costrutti predicativi di tipo frasale nelle diverse varietà romanze. Mentre le pseudorelative sono diffuse pressoché in tutta la Romània, con qualche variazione parametrica minore, i gerundi predicativi e gli infiniti preposizionali sono usati solo in alcune varietà. Negli studi linguistici sull'argomento è mancata finora l'ottica comparativa, sia tra varietà diverse, sia tra costrutti predicativi diversi. Il mio lavoro si prefissa lo scopo di colmare questa lacuna, senza ignorare però i costrutti percettivi composti da un infinito semplice, che da parte della letteratura sono stati paragonati alle strutture predicative delle pseudorelat…
Null subjects in generative grammar: A synchronic and diachronic perspective
2018
This book considers the null-subject phenomenon, whereby some languages lack an overtly realized referential subject in specific contexts. In generative syntax-the approach adopted in this volume-the phenomenon has traditionally been explained in terms of a ‘pro-drop’ parameter with associated cluster properties; more recently, however, it has become clear that pro-drop phenomena do not always correlate with all the initially predicted cluster properties. This volume returns to the centre of the debate surrounding the empirical phenomena associated with null subjects. Experts in the field explore the cluster properties associated with pro-drop; the types of null category involved in null-su…
Applying Minimalism in the Real World: Results From a Workshop
2020
Minimalism is a user-centered, contextual and goal-oriented approach to technical communication originally developed by John M. Carroll (1990). In minimalism, the aim is to produce user documentation that focuses on the user’s needs, helps the user recover from error situations, and strengthens the user’s skills in working with the system (Carroll & van der Meij 1995: 245). The challenge with minimalism has been its practical application: although user-centeredness – the core of minimalism – is the key issue in technical communication, the abstract nature of the approach and its focus on software documentation has made it difficult to apply in industry settings (Virtaluoto, Suojanen & Isohe…
Vastuullisuusarvot suomalaisten tekstiiliyritysten tarinoissa
2022
Textile industry causes significant negative environmental and social impacts. Sustainability in the industry has lately yielded more and more research interest, however, sustainability communication is underresearched area. In this paper, we will focus on sustainability communications in the Finnish textile industry through the stories of companies in their webpages. Storytelling has traditionally been a mode of transmitting, producing and reproducing the culture. Stories produce a structure in the reality, explain phenomena and concretize abstract concepts. In this research, we approach the stories as rhetorical devises, which address, attract and connect the reader to the company behind …
Minimalism for the Win : User-Centered Design for Guidance in Industrial Maintenance
2022
Background: We conducted an exploratory study to test the delivery of technical instructions built on the principles of minimalism. The aim was to investigate how we could support target users’ skill levels in a context-sensitive manner. Literature review: Related work examines minimalism, user needs and profiling, and industrial maintenance and technician experience. Research questions: 1. How can the semantic structure of DITA XML be utilized in delivering technical information to users based on their skill levels? 2. How would a layered system of information support the principles of minimalism? Methodology: We created material and tested the concept in user studies with maintenance pers…