Search results for "Mali"

Effects of Minimalist Footwear and Foot Strike Patterns on Plantar Pressure during a Prolonged Running

2022

The use of minimalist shoes (MS) in running involves changes in running mechanics compared to conventional shoes (CS), but there is still little research analysing the effects of this footwear on plantar pressure, which could help to understand some risk injury factors. Moreover, there are no studies examining the effects of a prolonged running and foot strike patterns on baropodometric variables in MS. Therefore, the aim of this study was to analyse the changes produced using MS on plantar pressure during a prolonged running, as well as its interaction with the time and foot strike pattern. Twenty-one experienced minimalist runners (age 38 ± 10 years, MS running experience 2 ± 1 years) ran…

Rec. a Anna Maria Gloria Capomacchia (a cura di)Animali tra mito e simbolo Roma, Carocci, 2009, pp. 126, ISBN 978-88-430-5031-4, € 14,50

2010

Rencensione al secondo volume della collana Neg/Otia nostra, Piccola biblioteca del Dipartimento di Studi storico-religiosi, dell’Università La Sapienza di Roma.

Suomalainen informalismi esteettisenä ja kontekstuaalisena ilmiönä varhaismodernismissa

1999

Yläkouluikäisten somalipoikien kokemuksia koululiikunnasta ja koulusta

2015

Tutkimuksen tarkoituksena oli selvittää yläkouluikäisten somalitaustaisten poikien kokemuksia koululiikunnasta ja koulusta. Tavoitteena oli saada tietoa siitä, miten somalitaustaisia oppilaita voidaan huomioida koululiikunnassa paremmin. Somalitaustaisten oppilaiden kokemusten pe-rusteella tutkimuksessa pyritään saamaan tietoa koululiikunnan ja koulun mielekkyydestä sekä siitä, miten liikuntatunneista voisi tehdä viihtyisämpiä oppilaille. Tutkimus oli menetelmälliseltä ratkaisultaan laadullinen, ja siinä oli piirteitä fenomenologis-hermeneuttisesta lähestymistavasta. Tutkimus toteutettiin haastattelemalla kuutta yläkoulussa opiskelevaa somalialaistaustaista oppilasta. Haastateltavat olivat …

Variation in the Sizes of Chthamalid Barnacle Post-Settlement Cyprids on European Shores

2001

As part of a wider study on the settlement and recruitment of Chthamalus spp. in Europe, this study investigated whether chthamalid cyprids can be separated by length on a European scale. Variation in cyprid length with latitude and temporal variation at selected localities were also examined. The lengths of cyprids collected between 1996-1999 on nine rocky shores in Europe are reported. Elminius modestus cyprids were found only at Roscoff, NW France and could be distinguished due to their Carapace shape and length. They showed a unimodal length distribution, measuring between 450 and 625 mum, with no variation in length between the two sampling dates (1997 and 1998). Based on carapace shap…

Hands-feet wireless devices: Test-retest reliability and discriminant validity of motor measures in Parkinson's disease telemonitoring

2022

Background Telemonitoring, a branch of telemedicine, involves the use of technological tools to remotely detect clinical data and evaluate patients. Telemonitoring of patients with Parkinson's disease (PD) should be performed using reliable and discriminant motor measures. Furthermore, the method of data collection and transmission, and the type of subjects suitable for telemonitoring must be well defined. Objective To analyze differences in patients with PD and healthy controls (HC) with the wearable inertial device SensHands-SensFeet (SH-SF), adopting a standardized acquisition mode, to verify if motor measures provided by SH-SF have a high discriminating capacity and high intraclass corr…

RNA-mediated therapies in myotonic dystrophy

2018

Myotonic dystrophy 1 (DM1) is a multisystemic neuromuscular disease caused by a dominantly inherited 'CTG' repeat expansion in the gene encoding DM Protein Kinase (DMPK). The repeats are transcribed into mRNA, which forms hairpins and binds with high affinity to the Muscleblind-like (MBNL) family of proteins, sequestering them from their normal function. The loss of function of MBNL proteins causes numerous downstream effects, primarily the appearance of nuclear foci, mis-splicing, and ultimately myotonia and other clinical symptoms. Antisense and other RNA-mediated technologies have been applied to target toxic-repeat mRNA transcripts to restore MBNL protein function in DM1 models, such as…

Myotonic dystrophy: candidate small molecule therapeutics

2017

Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …

Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila

2016

AbstractMyotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulation of MBNL proteins is, thus, a potential therapeutic approach to DM1. Here we identify two miRNAs, dme-miR-277 and dme-miR-304, that differentially regulate muscleblind RNA isoforms in miRNA sensor constructs. We also show that their sequestration by sponge constructs derepresses endogenous muscleblind not only in a wild type background but also in a DM1 Drosophila model expressing non-co…

Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis ge…

2016

AbstractMyotonic dystrophies (DM1–2) are neuromuscular genetic disorders caused by the pathological expansion of untranslated microsatellites. DM1 and DM2, are caused by expanded CTG repeats in the 3′UTR of the DMPK gene and CCTG repeats in the first intron of the CNBP gene, respectively. Mutant RNAs containing expanded repeats are retained in the cell nucleus, where they sequester nuclear factors and cause alterations in RNA metabolism. However, for unknown reasons, DM1 is more severe than DM2. To study the differences and similarities in the pathogenesis of DM1 and DM2, we generated model flies by expressing pure expanded CUG ([250]×) or CCUG ([1100]×) repeats, respectively, and compared …